DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp310a1 and cyp-13A11

DIOPT Version :9

Sequence 1:	NP_609891.1	Gene:	Cyp310a1 / 35115	FlyBaseID:	FBgn0032693	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_499704.1	Gene:	cyp-13A11 / 184472	WormBaseID:	WBGene00008809	Length:	517	Species:	Caenorhabditis elegans

Alignment Length:	517	Identity:	103/517 - (19%)
Similarity:	214/517 - (41%)	Gaps:	97/517 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLLPILLYSAVFLSVRHIY---SHWRRRGFPSEKAGITWSFLQKAY------RREFRHVEAICEA 58
            :::.:.:.|:|...|.:.:   ::|||.|.|..:.   :.||..|.      ...|..::.....
Worm     1 MIILLFVVSSVVGIVSYYFWTWTYWRRCGIPGPQG---YPFLGSALDMMDHENPPFLQLKKWTSQ 62

  Fly    59 YQSGKDRLLGIYCFFRPVLLVRNVELAQTILQQSNGHFSELKWDYISG--------------YRR 109
            |  ||  :.||.......|::.:..|...:..:...:|.....:.|.|              ..|
Worm    63 Y--GK--VYGITEGLLRTLVISDTNLIHEVFVKQYDNFYGRNLNPIQGDPNREKRVTLFSAQGHR 123

  Fly   110 FNLLEKLA-PMFGTKRLSEMFGQVQKVGDHLIHHLLDRQGQGCPQEVDIQQKLRVYSVNIIANLI 173
            :..|..:| |.|.:..|.::...|:.....|:.|:......|  :.:|:.:..:.:::::|..:.
Worm   124 WKRLRTIANPTFSSNNLRKIQVTVEDSALELLRHIEQHTAGG--KAIDVLEYFQEFTMDVIGRIA 186

  Fly   174 YGLDINNFEHEDHIL------------TSYLSHSQASIQSFTLGRLPQK-------------SSY 213
            .| ..::...::.:|            ..:||    .|....:|.:.:|             :..
Worm   187 MG-QPDSLMFKNPLLPCARDVFGKPRTALFLS----GILFPWIGPMIRKVVFYFTNVFNNPAAQI 246

  Fly   214 TYRLRDLIKQSVELR---EDHGL---IRKDILQLLVRFRNGNEVSGDKWQLEPINDADKLLSIKR 272
            .|:..:.::|.::.|   |..|:   ..:|.:.|.:      :...|..:||...|..| ..:|.
Worm   247 MYQTANAVEQRIKQRMAEEKAGIDPGEPQDFIDLFL------DAKSDDMELENNEDFTK-AGVKV 304

  Fly   273 LAKVAED--------LLKVSLDAVASTVTFTLLEILQEPLIVEKLRAEI-KELSNENGQLKFEEL 328
            ..::.:|        .|....|..|.:::::...:...|...:||:.|| :|.::.  ::.|::|
Worm   305 TRQLTKDEVVGQCFVFLIAGFDTTALSLSYSSFLLATHPKAQKKLQEEIDRECADP--EVTFDQL 367

  Fly   329 NGLRYMDMCLKETLRKYPPLPII-ERVCRKSYSLPNSKFTIDEGKTLMVPLLAMHRDEKYFSEPM 392
            :.|:||:..:|||||.||...:. .|.|.:|..:.|  :.|::|..::.....:|.|:..:.|..
Worm   368 SKLKYMECVIKETLRMYPLGALANSRRCMRSTKIGN--YEIEKGVDILCDTWTLHYDKSIWGEDA 430

  Fly   393 -KYKPLRFLQTANDVGQCEDKTKSNVFIGFGIGGSQCVGQNFAKLVIKVALIKLLQNFHLEL 453
             ::||.|:     :.|. |...:...:|.||:|..||:|...|.:..|:.|..:|:.:.||:
Worm   431 EEFKPERW-----ESGD-EHFYQKGGYIPFGLGPRQCIGMRLAYMEEKLLLSHILRKYTLEV 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp310a1	NP_609891.1	p450	69..454	CDD:299894	87/442 (20%)
cyp-13A11	NP_499704.1	p450	31..506	CDD:278495	96/487 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910