Protein Alignment Cyp310a1 and CYP3A5

DIOPT Version :9

• Sequence 1: NP_609891.1
• Gene: Cyp310a1 / 35115
• FlyBaseID: FBgn0032693
• Length: 492
• Species: Drosophila melanogaster
• Sequence 2: NP_000768.1
• Gene: CYP3A5 / 1577
• HGNCID: 2638
• Length: 502
• Species: Homo sapiens
• Alignment Length: 532
• Identity: 132/532 - (24%)
• Similarity: 233/532 - (43%)
• Gaps: 115/532 - (21%)

  Fly     2 WLLLPILLYSAVFLSVRHIY---SH--WRRRGFP------------SEKAGITWSFLQKAYRREF 49
            ||||      ||.|.:.::|   :|  ::|.|.|            |.:.|: |.|..:.|::
Human    12 WLLL------AVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGL-WKFDTECYKK-- 67

  Fly    50 RHVEAICEAYQSGKDRLLGIYCFFRPVLLVRNVELAQTIL----------QQSNGHFSELKWDYI 104
                       .||  :.|.|....|||.:.:.::.:|:|          ::|.|....:| ..|
Human    68 -----------YGK--MWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMK-SAI 118

  Fly   105 S-----GYRRFNLLEKLAPMFGTKRLSEMFGQVQKVGDHLIHHLLDRQGQGCPQEVDIQQKLRVY 164
            |     .::|...|  |:|.|.:.:|.|||..:.:.||.|:.:|.....:|.|  |.::.....|
Human   119 SLAEDEEWKRIRSL--LSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKP--VTLKDIFGAY 179

  Fly   165 SVNIIANLIYGLDINNFEH-EDHILTS--------YLSHSQASI----------QSFTLGRLPQK 210
            |:::|....:|::|::..: :|..:.|        :|.....||          ::..:...| |
Human   180 SMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFP-K 243

  Fly   211 SSYTYRLRDLIKQSVELREDHGLIRKDILQLLVRFRNGNEVSGDKWQLEPINDADKLLSIKRLAK 275
            .:..:..:.:.:.......|....|.|.|||::..:|..|           .::.|.||...||.
Human   244 DTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKE-----------TESHKALSDLELAA 297

  Fly   276 VAEDLLKVSLDAVASTVTFTLLEILQEPLIVEKLRAEIKELSNENGQLKFEELNGLRYMDMCLKE 340
            .:...:....:..:|.::|||.|:...|.:.:||:.||..:........::.:..:.|:||.:.|
Human   298 QSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNE 362

  Fly   341 TLRKYPPLPIIERVCRKSYSLPNSKFTIDEGKTLMVPLLAMHRDEKYFSEPMKYKPLRFLQTAND 405
            |||.:|....:||.|:|...: |..| |.:|..:::|..|:|.|.||::||.:::|.||
Human   363 TLRLFPVAIRLERTCKKDVEI-NGVF-IPKGSMVVIPTYALHHDPKYWTEPEEFRPERF------ 419

  Fly   406 VGQCEDKTKSNVFIGFGIGGSQCVGQNFAKLVIKVALIKLLQNFH----------LELDANQVK- 459
             .:.:|.....::..||.|...|:|..||.:.:|:|||::||||.          |:||...:.
Human   420 -SKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQ 483

  Fly   460 -----TLKVSHR 466
                 .|||..|
Human   484 PEKPIVLKVDSR 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp310a1	NP_609891.1	p450	69..454	CDD:299894	106/428 (25%)
CYP3A5	NP_000768.1	p450	39..492	CDD:365848	118/494 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820