Protein Alignment Cyp310a1 and CYP3A4

DIOPT Version :9

• Sequence 1: NP_609891.1
• Gene: Cyp310a1 / 35115
• FlyBaseID: FBgn0032693
• Length: 492
• Species: Drosophila melanogaster
• Sequence 2: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Alignment Length: 533
• Identity: 137/533 - (25%)
• Similarity: 234/533 - (43%)
• Gaps: 104/533 - (19%)

  Fly     2 WLLLPILLYSAVFLSVRHIYSH--WRRRGFPSEKAGIT-WSFLQK--AYRREFRHVEAICEAYQS 61
            ||||.:   |.|.|.:...:||  :::.|.|    |.| ..||..  :|.:.|...:..|.. :.
Human    12 WLLLAV---SLVLLYLYGTHSHGLFKKLGIP----GPTPLPFLGNILSYHKGFCMFDMECHK-KY 68

  Fly    62 GKDRLLGIYCFFRPVLLVRNVELAQTILQQSNGHFSELKWDYISGYRRF---------------- 110
            ||  :.|.|...:|||.:.:.::.:|:|.:.       .:...:..|.|
Human    69 GK--VWGFYDGQQPVLAITDPDMIKTVLVKE-------CYSVFTNRRPFGPVGFMKSAISIAEDE 124

  Fly   111 ---NLLEKLAPMFGTKRLSEMFGQVQKVGDHLIHHLLDRQGQGCPQEVDIQQKLRVYSVNIIANL 172
               .|...|:|.|.:.:|.||...:.:.||.|:.:|......|.|  |.::.....||:::|.:.
Human   125 EWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKP--VTLKDVFGAYSMDVITST 187

  Fly   173 IYGLDINNF--------EHEDHILT-SYLSHSQASIQSF----------TLGRLPQKSSYTYRLR 218
            .:|::|::.        |:...:|. .:|.....||..|          .:...|::  .|..||
Human   188 SFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPRE--VTNFLR 250

  Fly   219 DLIKQSVELR-EDHGLIRKDILQLLVRFRNGNEVSGDKWQLEPINDADKLLSIKRLAKVAEDLLK 282
            ..:|:..|.| ||....|.|.|||::..:|..|....|             ::..|..||:.::.
Human   251 KSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHK-------------ALSDLELVAQSIIF 302

  Fly   283 V--SLDAVASTVTFTLLEILQEPLIVEKLRAEIKELSNENGQLKFEELNGLRYMDMCLKETLRKY 345
            :  ..:..:|.::|.:.|:...|.:.:||:.||..:........::.:..:.|:||.:.||||.:
Human   303 IFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLF 367

  Fly   346 PPLPIIERVCRKSYSLPNSKFTIDEGKTLMVPLLAMHRDEKYFSEPMKYKPLRFLQTANDVGQCE 410
            |....:||||:|...: |..| |.:|..:|:|..|:|||.||::||.|:.|.||          .
Human   368 PIAMRLERVCKKDVEI-NGMF-IPKGVVVMIPSYALHRDPKYWTEPEKFLPERF----------S 420

  Fly   411 DKTKSN----VFIGFGIGGSQCVGQNFAKLVIKVALIKLLQNFHLELDANQVKTLKVS------- 464
            .|.|.|    ::..||.|...|:|..||.:.:|:|||::||||..:........||:|
Human   421 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQP 485

  Fly   465 HRPAPF-IHTKDG 476
            .:|... :.::||
Human   486 EKPVVLKVESRDG 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp310a1	NP_609891.1	p450	69..454	CDD:299894	110/429 (26%)
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	125/496 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920