Protein Alignment Cyp310a1 and CYP4F8

DIOPT Version :10

• Sequence 1: NP_609891.1
• Gene: Cyp310a1 / 35115
• FlyBaseID: FBgn0032693
• Length: 492
• Species: Drosophila melanogaster
• Sequence 2: NP_009184.1
• Gene: CYP4F8 / 11283
• HGNCID: 2648
• Length: 520
• Species: Homo sapiens
• Alignment Length: 550
• Identity: 119/550 - (21%)
• Similarity: 219/550 - (39%)
• Gaps: 130/550 - (23%)

  Fly     2 WLLLPILLYSAVFLSVRHIYSHWRR-RGFPSEKAGITWSF----LQKAYRREFRHVEAICEAYQS 61
            |||..||.::..|      |.:.|| |.||..:.. .|..    |........|.:..:...|..
Human    29 WLLARILAWTYAF------YHNGRRLRCFPQPRKQ-NWFLGHLGLVTPTEEGLRVLTQLVATYPQ 86

  Fly    62 GKDRLLGIYCFFRPVLLVRNVELAQTILQQSNG-------HFSELK-W----------DYISGYR 108
            |..|.||.   ..|::.:.:.::.::::..|:.       .:..|| |          |....:|
Human    87 GFVRWLGP---ITPIINLCHPDIVRSVINTSDAITDKDIVFYKTLKPWLGDGLLLSVGDKWRHHR 148

  Fly   109 R-------FNLLEKLAPMFGTKRLSEMFGQVQKVGDHLIHHLLDRQGQGCPQEVDIQQKLRVYSV 166
            |       ||:|:....:| :|..:.|..:.|:         |..:|..|   :|:.:.:.:.::
Human   149 RLLTPAFHFNILKPYIKIF-SKSANIMHAKWQR---------LAMEGSTC---LDVFEHISLMTL 200

  Fly   167 NIIANLIYGLDINNFEHEDHILTSYLSHSQASIQSFTLGRLPQKSSYTYRLRDLI---------- 221
            :.:...|:..|.|..|.....:|:.:..|...:         ::::..:|.:|.:
Human   201 DSLQKCIFSFDSNCQEKPSEYITAIMELSALVV---------KRNNQFFRYKDFLYFLTPCGRRF 256

  Fly   222 KQSVELRED--HGLIRK-----------DILQ--------------LLVRFRNGNEVSGDKWQLE 259
            .::..|..|  ..:|::           |.||              ||...:||.|:|.:..:.|
Human   257 HRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFIDVLLLSEDKNGKELSDEDIRAE 321

  Fly   260 PINDADKLLSIKRLAKVAEDLLKVSLDAVASTVTFTLLEILQEPLIVEKLRAEIKEL--SNENGQ 322
                             |:..:....|..||.:::.|..:.:.|...|:.|.|::||  ..|..:
Human   322 -----------------ADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKE 369

  Fly   323 LKFEELNGLRYMDMCLKETLRKYPPLPIIERVCRKSYSLPNSKFTIDEGKTLMVPLLAMHRDEKY 387
            :::::|..|.::.|||||:||.:||:|...|.|.:...||:|: .|.:|....:.:.|:|.:...
Human   370 IEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSR-VIPKGNVCNINIFAIHHNPSV 433

  Fly   388 FSEPMKYKPLRFLQTANDVGQCEDKTKSNVFIGFGIGGSQCVGQNFAKLVIKVALIKLLQNFHLE 452
            :.:|..|.|.||     |....: |.....||.|..|...|:||.||...:||.|...|..|.:.
Human   434 WPDPEVYDPFRF-----DPENAQ-KRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRIL 492

  Fly   453 LDANQVKTLKVSHRPAPFIHTKDGLKVKLK 482
            .|..:.:     ..|...:..:|||.::::
Human   493 PDHREPR-----RTPEIVLRAEDGLWLRVE 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp310a1	NP_609891.1	CYP6-like	62..478	CDD:410679	102/479 (21%)
CYP4F8	NP_009184.1	CYP4F	74..515	CDD:410772	105/494 (21%)