Protein Alignment Cyp310a1 and cyp3a4

DIOPT Version :10

• Sequence 1: NP_609891.1
• Gene: Cyp310a1 / 35115
• FlyBaseID: FBgn0032693
• Length: 492
• Species: Drosophila melanogaster
• Sequence 2: XP_002943949.2
• Gene: cyp3a4 / 100494419
• XenbaseID: XB-GENE-984218
• Length: 504
• Species: Xenopus tropicalis
• Alignment Length: 516
• Identity: 122/516 - (23%)
• Similarity: 223/516 - (43%)
• Gaps: 129/516 - (25%)

  Fly     2 WLLLPILLYSAVFLSVRHIYSHW-----RRRGFPSEKAGIT-----WSFLQKAYRREFRH--VEA 54
            |:||.:||...:      :|..|     ::.|.|    |.|     .:||      |||.  ::.
 Frog    12 WILLAVLLVLIL------LYGIWPYGLFKKMGIP----GPTPLPFIGTFL------EFRKGMIQF 60

  Fly    55 ICEAYQSGKDRLLGIYCFFRPVLLVRNVELAQTILQQSNGHFSELKWDY--ISGYRRFNL---LE 114
            ..|.::. ..|:.|:|...:|||.:.:..:.:|||         :|..|  .:..|.|.|   ||
 Frog    61 DIECFKK-YGRMWGMYDGRQPVLAIMDPAIIKTIL---------VKECYTNFTNRRNFGLNGPLE 115

  Fly   115 K----------------LAPMFGTKRLSEMFGQVQKVGDHLIHHL---LDRQGQGCPQEVDIQQK 160
            .                |:|.|.:.:|.|||..::...|.|:.::   :|:......::|
 Frog   116 SAITVAEDEQWKRIRSVLSPTFTSGKLKEMFQIMKDYSDILVKNVQVSVDKDEPCATKDV----- 175

  Fly   161 LRVYSVNIIANLIYGLDINNFE--------HEDHIL-TSYLS----------HSQASIQSFTLGR 206
            :..||:::|.:..:.::|::.:        |..::| |.:||          ..:...:...:..
 Frog   176 IGAYSMDVITSTSFSVNIDSLQNPSNPFVIHIKNLLKTGFLSPVIIFAVIFPFLRPIFEVLNISF 240

  Fly   207 LPQKSSYTYRLRDLIKQSVELRE--DHGLIRKDILQLLV--RFRNGNEVSGDKWQLEPINDADKL 267
            .|:  .:|....:.:....|.|:  ||. .|.|:|||:|  ....||:.|.   |.:.:.||:.:
 Frog   241 FPK--DFTQFFMNAVTSFREKRKKGDHS-GRVDLLQLMVDSGTTEGNDSSN---QHKALTDAEIM 299

  Fly   268 LSIKRLAKVAEDLLKV--SLDAVASTVTFTLLEILQEPLIVEKLRAEIKELSNENGQLKFEELNG 330
                     |:.|:.:  ..:..::.:::....:...|.:.:||..||.....:.....::.|..
 Frog   300 ---------AQSLIFIFAGYETTSTALSYLFYNLATHPDVQQKLHEEIDSFLPDKASPTYDILMQ 355

  Fly   331 LRYMDMCLKETLRKYPPLPIIERVCRKSYSLPNSKFTIDEGKTLMVPLLAMHRDEKYFSEPMKYK 395
            :.|:||.::||||.:||...:|||.:::..:  :..:|.:|...|:|...:.||.:|:.||.:::
 Frog   356 MEYLDMVIQETLRLFPPAGRLERVSKQNVEI--NGVSIPKGTVAMIPAYVLQRDPEYWPEPEEFR 418

  Fly   396 PLRFLQTANDVGQCEDKTKSN-------VFIGFGIGGSQCVGQNFAKLVIKVALIKLLQNF 449
            |.||             :|.|       .|:.||.|...|:|..||.|.:|||:..|||||
 Frog   419 PERF-------------SKENRATQTPFTFLPFGDGPRNCIGLRFALLSMKVAIATLLQNF 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp310a1	NP_609891.1	CYP6-like	62..478	CDD:410679	105/444 (24%)
cyp3a4	XP_002943949.2	CYP3A	67..495	CDD:410743	105/445 (24%)