Protein Alignment IFT46 and IFT46

DIOPT Version :10

• Sequence 1: NP_609890.2
• Gene: IFT46 / 35114
• FlyBaseID: FBgn0032692
• Length: 416
• Species: Drosophila melanogaster
• Sequence 2: NP_064538.3
• Gene: IFT46 / 56912
• HGNCID: 26146
• Length: 355
• Species: Homo sapiens
• Alignment Length: 354
• Identity: 98/354 - (27%)
• Similarity: 145/354 - (40%)
• Gaps: 118/354 - (33%)

  Fly    60 RRMFQNNSTDDDGLLQDIIDHDDEAE-DSEDDDDSEMQLPQGMTMGVGMTGLVPGPNMQKRPGSN 123
            :|.|..|..|||       |.||.:| ||:.|||.|
Human    77 QRGFSENEDDDD-------DDDDSSETDSDSDDDDE----------------------------- 105

  Fly   124 RSSKQVPDDTLSSGSEEAAMGGRMGSGGARGGAKLPHQKLTLPMRGSASGAGRSKRQDDQSFIMS 188
                           |..|                       |:.|:...|
Human   106 ---------------EHGA-----------------------PLEGAYDPA-------------- 118

  Fly   189 ADKWEDLSVPGELKELFPYIVKYTPQTIDTPFHLQPFIPEFVPAVGDVDALLKVQAPPLLQPQRQ 253
              .:|.|.|..|:||||.||.:||||.||....|:||||:|:|||||:||.|||..|
Human   119 --DYEHLPVSAEIKELFQYISRYTPQLIDLDHKLKPFIPDFIPAVGDIDAFLKVPRP-------- 173

  Fly   254 KDLNDHLEKLGLWLLDEPSGAQSEPSLLNMKLRSVLSGSMGRN-PRHASSASLVPTARSGKDIEK 317
               :...:.|||.:|||||..||:|::|::.|   ...|...| .:|....||....::.|.|:.
Human   174 ---DGKPDNLGLLVLDEPSTKQSDPTVLSLWL---TENSKQHNITQHMKVKSLEDAEKNPKAIDT 232

  Fly   318 WITEVEQVHMTQ---SMYDVQPRKDIDALLEDWPRSFGDEQTINALDQAYRSCLQQNISVAEYVG 379
            ||..:.::|.::   :::..:|..|||.|:::|...|.:.....:|..|...|     |:|||:.
Human   233 WIESISELHRSKPPATVHYTRPMPDIDTLMQEWSPEFEELLGKVSLPTAEIDC-----SLAEYID 292

  Fly   380 VLCERFGVEGPLESQADYIHNVQTLFALY 408
            ::|....:  |:....  |.::..||:||
Human   293 MICAILDI--PVYKSR--IQSLHLLFSLY 317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IFT46	NP_609890.2	IFT46_B_C	188..409	CDD:463532	77/225 (34%)
IFT46	NP_064538.3	IFT46_B_C	116..318	CDD:463532	54/202 (27%)