DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atac2 and kat14

DIOPT Version :9

Sequence 1:	NP_609889.1	Gene:	Atac2 / 35113	FlyBaseID:	FBgn0032691	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001072678.1	Gene:	kat14 / 780135	XenbaseID:	XB-GENE-947246	Length:	776	Species:	Xenopus tropicalis

Alignment Length:	864	Identity:	268/864 - (31%)
Similarity:	388/864 - (44%)	Gaps:	250/864 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SPVEDD---NYLE-----CQECRRMVHIKCLPHACTPGD----LLGDVFFEFTCVKCVLDKAKES 71
            |.|.||   .::|     |.:|:     |.:|.:...||    |.||.:|:|.|..|..|.
Frog    55 SDVGDDVDPPWMEEMPFYCDKCQ-----KWIPASQLKGDPPSYLKGDNYFKFICFACSEDG---- 110

  Fly    72 VIPSDLEPIKEVIVRQRIPWLLVLTLTLYNLSIKQKGLGHHGFFHWRTHIISFVDKNWNYIFGPN 136
                     ||...|.|:.|..|:.|.:||||:::  .|..|:|.|:..|.||::|:||::.| |
Frog   111 ---------KEQFERLRLTWQQVVMLAMYNLSLEE--TGRQGYFRWKEDICSFIEKHWNFLLG-N 163

  Fly   137 VRRRKQWTGSVSGALSHNSPEYFQSGLDVFQENGWWKLA---KPFQTP----------------- 181
            .::...|..:|:|.||..||.:|:||...|.|.|||||.   .|...|
Frog   164 RKKTSTWWSTVAGCLSVGSPLFFRSGAQEFGEPGWWKLVHNKPPIMRPEGEKYSIALQKTKVPVK 228

  Fly   182 ---------------------RSVLKEYEKKQQLRLQMRIEKRLPAA----DETSCSSEISVADH 221
                                 .|.::..||:.:.:....|.:....|    |.::.|:.:..:..
Frog   229 TSLDPVITVEGLRKRASRNPVESAMELKEKRSRTQEAKEIRRAQKEASGFVDRSTSSTPVKFSSG 293

  Fly   222 AQDNPPLI--KAEAEKPSSTEGCARTIPYMGRLPKIQTQPSPLSQETLPGPPILQENIAPPSQKE 284
            ....|.::  |.|....||.....||       |.....|||....:.||.|  ..:.|.||...
Frog   294 RSRRPDIVLEKGEVIDFSSMSSSDRT-------PMTSPSPSPSLDFSAPGTP--ASHSATPSLLS 349

  Fly   285 EEPQNQPMSMVQAGLMDFLAESLESDDFTMFGNLPGI--MPP---PLIGAGKNDFFMTEPLLHAP 344
            |......:...||...|  .|.||:|....    ||:  :||   .|.|:       :.|:.|..
Frog   350 EADLIPDVMPPQALFHD--DEELEADSVID----PGMEYIPPTSASLAGS-------STPICHKK 401

  Fly   345 LNNEGLFDMDTNFAIPNTADETKPISTEEPAAESSEEQKEGEVEDEKPEEDESPDYQPRIVQVTN 409
            :.|                    |:..::..  .|||::...:|:|.||
Frog   402 VKN--------------------PLQIKQEI--ESEEERSERIEEELPE---------------- 428

  Fly   410 YQAQEANESIKEEPLEEIMQDDDVTTNSKSSILEPCKPSGFVRQPRRNWPWLQEAQDPDDMAIPS 474
                   :|.:|                              |:.::..|            :|:
Frog   429 -------DSWRE------------------------------RRRKKKGP------------LPT 444

  Fly   475 ENLK-------LINAYEEQKLYQRLD---RIFALEHQCHISIPAYVRRLYRKLSLRKWKRDHNRH 529
            |:.|       .|:.|||:.|.:||:   ...|:.|:        .|||.|||.:|:.||:....
Frog   445 ESDKNKGTQYNAISLYEEKLLLKRLETCPNAVAITHE--------ARRLRRKLLVRQAKRERGLP 501

  Fly   530 IFNLDEHIDPLGRARLKMLG-------------------HQKA----EILDRYQL---LAHSRQD 568
            :|:||:.::    |.|:::|                   :|..    .||||||.   :....:.
Frog   502 LFDLDQAVN----AALQLVGGVYGAREGSVSRPAPSGPEYQATAKDYRILDRYQTALPVTKRHRH 562

  Fly   569 ARSSFHARLAGCTQYE---LFESPYSQRVLHPFIFRSETMAPPWLKLMCELQHRVNGSHP----- 625
            |.:.|..||.||...:   ...|||:.|||.|:|.|.........:|:.|::...:.:.|
Frog   563 AATRFVYRLGGCEDKDSDLSIVSPYTARVLKPYIRRDYETKTLKQQLLAEIKAFPHRNEPDWQPE 627

  Fly   626 TRSTIDFCFVRPQHIPAVNALLQSTFWPNIDVSECLSYPDYSVVALYKKLVIGCGFLVPDVGYNE 690
            ..|.||:|:|||.|||.:|::.|..|||.||:||||.|||:||||||||:|:..||:||||.|||
Frog   628 PESPIDYCYVRPSHIPTINSICQEFFWPGIDLSECLQYPDFSVVALYKKVVVAFGFMVPDVKYNE 692

  Fly   691 AYISFMAVRPCWQRSGIASFMLYHLIQTCMSKDITLHVSATNAAVMLYQKFGFKMEEIILDFYDK 755
            |||||:.|.|.|:|:|||:||:||||||||.||:||||||.::|::||||||||.:|.|||||||
Frog   693 AYISFLFVHPEWRRAGIATFMIYHLIQTCMGKDVTLHVSANSSAMLLYQKFGFKTQEYILDFYDK 757

  Fly   756 YLPLDSKQSRNAFFLRLQR 774
            |.|||||:.::||||||:|
Frog   758 YYPLDSKECKHAFFLRLRR 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atac2	NP_609889.1	PHD	14..63	CDD:214584	17/55 (31%)
		rimI	639..753	CDD:273701	78/113 (69%)
		Acetyltransf_1	676..744	CDD:278980	47/67 (70%)
kat14	NP_001072678.1	Acetyltransf_1	<666..745	CDD:366181	56/78 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	163	1.000	Domainoid score	I3938
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	335	1.000	Inparanoid score	I2362
OMA	1	1.010	-	-		QHG46944
OrthoDB	1	1.010	-	-		D1404086at2759
OrthoFinder	1	1.000	-	-		FOG0006920
OrthoInspector	1	1.000	-	-		oto105082
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10265
SonicParanoid	1	1.000	-	-		X5829
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.010