Protein Alignment Atac2 and KAT14

DIOPT Version :10

• Sequence 1: NP_609889.1
• Gene: Atac2 / 35113
• FlyBaseID: FBgn0032691
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_065397.4
• Gene: KAT14 / 57325
• HGNCID: 15904
• Length: 782
• Species: Homo sapiens
• Alignment Length: 842
• Identity: 261/842 - (30%)
• Similarity: 380/842 - (45%)
• Gaps: 214/842 - (25%)

  Fly    23 DDNYLE------CQECRRMVHIKCLPHACTPGDLLGDVFFEFTCVKCVLDKAKESVIPSDLEPIK 81
            |.:::|      |.:|::.:....|....:  .|.||.||.|||..|..|.             |
Human    65 DVSWMEEQLSYFCDKCQKWIPASQLREQLS--YLKGDNFFRFTCSDCSADG-------------K 114

  Fly    82 EVIVRQRIPWLLVLTLTLYNLSIKQKGLGHHGFFHWRTHIISFVDKNWNYIFGPNVRRRKQWTGS 146
            |...|.::.|..|:.|.:||||:  :|.|..|:|.|:..|.:|::|:|.::.| |.::...|..:
Human   115 EQYERLKLTWQQVVMLAMYNLSL--EGSGRQGYFRWKEDICAFIEKHWTFLLG-NRKKTSTWWST 176

  Fly   147 VSGALSHNSPEYFQSGLDVFQENGWWKL-------------------------AKPFQTP----- 181
            |:|.||..||.||:||...|.|.|||||                         :||...|
Human   177 VAGCLSVGSPMYFRSGAQEFGEPGWWKLVHNKPPTMKPEGEKLSASTLKIKAASKPTLDPIITVE 241

  Fly   182 -------------RSVLKEYEKKQQLRLQMRIEKRLPAA--DETSCSSEISVADHAQDNPPLI-- 229
                         ...|||...:.|....:|..::..|.  |.::.|:.:......: .|.:|
Human   242 GLRKRASRNPVESAMELKEKRSRTQEAKDIRRAQKEAAGFLDRSTSSTPVKFISRGR-RPDVILE 305

  Fly   230 KAEAEKPSSTEGCARTIPYMGRLPKIQTQPSPLSQETLPGPPILQENIAPPSQKEEEPQNQPMSM 294
            |.|....||.....||       |.....|||....:.||.|  ..:.|.||...|
Human   306 KGEVIDFSSLSSSDRT-------PLTSPSPSPSLDFSAPGTP--ASHSATPSLLSE--------- 352

  Fly   295 VQAGLMDFLAESLESDDFTMFGNLPGIMPPPLIGAGKNDFFMTEPLLH--APLNNEGLFDMDTNF 357
              |.|                  :|.:|||             :.|.|  ..:..:|:.|....:
Human   353 --ADL------------------IPDVMPP-------------QALFHDDDEMEGDGVIDPGMEY 384

  Fly   358 AIPNTAD-ETKPISTEEPAAESSEE-QKEGEVEDEKPEEDESPDYQPRIVQVTNYQAQEANESIK 420
            ..|.... .:.|:..........|: ::|.|.|:|||:.
Human   385 VPPPAGSVASGPVVGVRKKVRGPEQIKQEVESEEEKPDR-------------------------- 423

  Fly   421 EEPLEEIMQDDDVTTNSKSSILEPCKPSGFVRQPRRNWPWLQEAQDPDDMAIPSENLKLINAYEE 485
                   |..|...|:|.:|:.        .|...:..|.|::...|.:     .....::.|||
Human   424 -------MDIDSEDTDSNTSLQ--------TRAREKRKPQLEKDTKPKE-----PRYTPVSIYEE 468

  Fly   486 QKLYQRLDRIFALEHQC--HISIPAYVRRLYRKLSLRKWKRDHNRHIFNLDEHID---------- 538
            :.|.:||:       .|  .:::....|||.|||.:|:.|||....:|:||:.::
Human   469 KLLLKRLE-------ACPGAVAMTPEARRLKRKLIVRQAKRDRGLPLFDLDQVVNAALLLVDGIY 526

  Fly   539 ----------PLGRARLKMLGHQKAEILDRYQLLAHSRQDAR---SSFHARLAGCTQYELFE--- 587
                      |.|:|..:.. .|...||||||....||:..|   :.|..||.|.....:.:
Human   527 GAKEGGISRLPAGQATYRTT-CQDFRILDRYQTSLPSRKGFRHQTTKFLYRLVGSEDMAVDQSIV 590

  Fly   588 SPYSQRVLHPFIFRSETMAPPWLKLMCELQHRVNGSHP-----TRSTIDFCFVRPQHIPAVNALL 647
            |||:.|:|.|:|.|.....||.|:|:.:::..::.|.|     ..:.:|:|:|||.|||.:|::.
Human   591 SPYTSRILKPYIRRDYETKPPKLQLLSQIRSHLHRSDPHWTPEPDAPLDYCYVRPNHIPTINSMC 655

  Fly   648 QSTFWPNIDVSECLSYPDYSVVALYKKLVIGCGFLVPDVGYNEAYISFMAVRPCWQRSGIASFML 712
            |..|||.||:||||.|||:|||.||||::|..||:||||.||||||||:.|.|.|:|:|||:||:
Human   656 QEFFWPGIDLSECLQYPDFSVVVLYKKVIIAFGFMVPDVKYNEAYISFLFVHPEWRRAGIATFMI 720

  Fly   713 YHLIQTCMSKDITLHVSATNAAVMLYQKFGFKMEEIILDFYDKYLPLDSKQSRNAFFLRLQR 774
            ||||||||.||:||||||:|.|::||||||||.||.:|||||||.||:|.:.::||||||:|
Human   721 YHLIQTCMGKDVTLHVSASNPAMLLYQKFGFKTEEYVLDFYDKYYPLESTECKHAFFLRLRR 782

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atac2	NP_609889.1	PHD	14..63	CDD:214584	13/45 (29%)
		RimI	678..753	CDD:440224	53/74 (72%)
KAT14	NP_065397.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	13..33
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	251..282		6/30 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	315..346		9/39 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	400..460		16/105 (15%)
		RimI	686..761	CDD:440224	53/74 (72%)