DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atac2 and KAT14

DIOPT Version :9

Sequence 1:	NP_609889.1	Gene:	Atac2 / 35113	FlyBaseID:	FBgn0032691	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001371121.2	Gene:	KAT14 / 57325	HGNCID:	15904	Length:	782	Species:	Homo sapiens

Alignment Length:	842	Identity:	261/842 - (30%)
Similarity:	380/842 - (45%)	Gaps:	214/842 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 DDNYLE------CQECRRMVHIKCLPHACTPGDLLGDVFFEFTCVKCVLDKAKESVIPSDLEPIK 81
            |.:::|      |.:|::.:....|....:  .|.||.||.|||..|..|.             |
Human    65 DVSWMEEQLSYFCDKCQKWIPASQLREQLS--YLKGDNFFRFTCSDCSADG-------------K 114

  Fly    82 EVIVRQRIPWLLVLTLTLYNLSIKQKGLGHHGFFHWRTHIISFVDKNWNYIFGPNVRRRKQWTGS 146
            |...|.::.|..|:.|.:||||:  :|.|..|:|.|:..|.:|::|:|.::.| |.::...|..:
Human   115 EQYERLKLTWQQVVMLAMYNLSL--EGSGRQGYFRWKEDICAFIEKHWTFLLG-NRKKTSTWWST 176

  Fly   147 VSGALSHNSPEYFQSGLDVFQENGWWKL-------------------------AKPFQTP----- 181
            |:|.||..||.||:||...|.|.|||||                         :||...|
Human   177 VAGCLSVGSPMYFRSGAQEFGEPGWWKLVHNKPPTMKPEGEKLSASTLKIKAASKPTLDPIITVE 241

  Fly   182 -------------RSVLKEYEKKQQLRLQMRIEKRLPAA--DETSCSSEISVADHAQDNPPLI-- 229
                         ...|||...:.|....:|..::..|.  |.::.|:.:......: .|.:|
Human   242 GLRKRASRNPVESAMELKEKRSRTQEAKDIRRAQKEAAGFLDRSTSSTPVKFISRGR-RPDVILE 305

  Fly   230 KAEAEKPSSTEGCARTIPYMGRLPKIQTQPSPLSQETLPGPPILQENIAPPSQKEEEPQNQPMSM 294
            |.|....||.....||       |.....|||....:.||.|  ..:.|.||...|
Human   306 KGEVIDFSSLSSSDRT-------PLTSPSPSPSLDFSAPGTP--ASHSATPSLLSE--------- 352

  Fly   295 VQAGLMDFLAESLESDDFTMFGNLPGIMPPPLIGAGKNDFFMTEPLLH--APLNNEGLFDMDTNF 357
              |.|                  :|.:|||             :.|.|  ..:..:|:.|....:
Human   353 --ADL------------------IPDVMPP-------------QALFHDDDEMEGDGVIDPGMEY 384

  Fly   358 AIPNTAD-ETKPISTEEPAAESSEE-QKEGEVEDEKPEEDESPDYQPRIVQVTNYQAQEANESIK 420
            ..|.... .:.|:..........|: ::|.|.|:|||:.
Human   385 VPPPAGSVASGPVVGVRKKVRGPEQIKQEVESEEEKPDR-------------------------- 423

  Fly   421 EEPLEEIMQDDDVTTNSKSSILEPCKPSGFVRQPRRNWPWLQEAQDPDDMAIPSENLKLINAYEE 485
                   |..|...|:|.:|:.        .|...:..|.|::...|.:     .....::.|||
Human   424 -------MDIDSEDTDSNTSLQ--------TRAREKRKPQLEKDTKPKE-----PRYTPVSIYEE 468

  Fly   486 QKLYQRLDRIFALEHQC--HISIPAYVRRLYRKLSLRKWKRDHNRHIFNLDEHID---------- 538
            :.|.:||:       .|  .:::....|||.|||.:|:.|||....:|:||:.::
Human   469 KLLLKRLE-------ACPGAVAMTPEARRLKRKLIVRQAKRDRGLPLFDLDQVVNAALLLVDGIY 526

  Fly   539 ----------PLGRARLKMLGHQKAEILDRYQLLAHSRQDAR---SSFHARLAGCTQYELFE--- 587
                      |.|:|..:.. .|...||||||....||:..|   :.|..||.|.....:.:
Human   527 GAKEGGISRLPAGQATYRTT-CQDFRILDRYQTSLPSRKGFRHQTTKFLYRLVGSEDMAVDQSIV 590

  Fly   588 SPYSQRVLHPFIFRSETMAPPWLKLMCELQHRVNGSHP-----TRSTIDFCFVRPQHIPAVNALL 647
            |||:.|:|.|:|.|.....||.|:|:.:::..::.|.|     ..:.:|:|:|||.|||.:|::.
Human   591 SPYTSRILKPYIRRDYETKPPKLQLLSQIRSHLHRSDPHWTPEPDAPLDYCYVRPNHIPTINSMC 655

  Fly   648 QSTFWPNIDVSECLSYPDYSVVALYKKLVIGCGFLVPDVGYNEAYISFMAVRPCWQRSGIASFML 712
            |..|||.||:||||.|||:|||.||||::|..||:||||.||||||||:.|.|.|:|:|||:||:
Human   656 QEFFWPGIDLSECLQYPDFSVVVLYKKVIIAFGFMVPDVKYNEAYISFLFVHPEWRRAGIATFMI 720

  Fly   713 YHLIQTCMSKDITLHVSATNAAVMLYQKFGFKMEEIILDFYDKYLPLDSKQSRNAFFLRLQR 774
            ||||||||.||:||||||:|.|::||||||||.||.:|||||||.||:|.:.::||||||:|
Human   721 YHLIQTCMGKDVTLHVSASNPAMLLYQKFGFKTEEYVLDFYDKYYPLESTECKHAFFLRLRR 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atac2	NP_609889.1	PHD	14..63	CDD:214584	13/45 (29%)
		rimI	639..753	CDD:273701	78/113 (69%)
		Acetyltransf_1	676..744	CDD:278980	48/67 (72%)
KAT14	NP_001371121.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	13..33
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	251..282		6/30 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	315..346		9/39 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..460		16/105 (15%)
		Acetyltransf_1	<672..751	CDD:395465	56/78 (72%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149719
Domainoid	1	1.000	175	1.000	Domainoid score	I3669
eggNOG	1	0.900	-	-		E1_COG0456
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	343	1.000	Inparanoid score	I2341
Isobase	1	0.950	-	0	Normalized mean entropy	S7398
OMA	1	1.010	-	-		QHG46944
OrthoDB	1	1.010	-	-		D1404086at2759
OrthoFinder	1	1.000	-	-		FOG0006920
OrthoInspector	1	1.000	-	-		oto91304
orthoMCL	1	0.900	-	-		OOG6_105880
Panther	1	1.100	-	-	LDO	PTHR20916
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10265
SonicParanoid	1	1.000	-	-		X5829
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.790