DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atac2 and Kat14

DIOPT Version :9

Sequence 1:	NP_609889.1	Gene:	Atac2 / 35113	FlyBaseID:	FBgn0032691	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001178784.1	Gene:	Kat14 / 362224	RGDID:	1309538	Length:	779	Species:	Rattus norvegicus

Alignment Length:	842	Identity:	261/842 - (30%)
Similarity:	382/842 - (45%)	Gaps:	217/842 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 DDNYLE------CQECRRMVHIKCLPHACTPGDLLGDVFFEFTCVKCVLDKAKESVIPSDLEPIK 81
            |.:::|      |.:|::.:....|....:  .|.||.||.|||..|..|.             |
  Rat    65 DISWMEEQLSYFCDKCQKWIPASQLREQLS--YLKGDNFFRFTCADCSADG-------------K 114

  Fly    82 EVIVRQRIPWLLVLTLTLYNLSIKQKGLGHHGFFHWRTHIISFVDKNWNYIFGPNVRRRKQWTGS 146
            |...|.::.|..|:.|.:||||:  :|.|..|:|.|:..|.:|::|:|.::.| |.::...|..:
  Rat   115 EQSERLKLTWQQVVMLAMYNLSL--EGSGRQGYFRWKEDICAFIEKHWTFLLG-NRKKTSTWWST 176

  Fly   147 VSGALSHNSPEYFQSGLDVFQENGWWKLAKPFQTPRSVLKEYEKKQQLRLQMRIEK--------- 202
            |:|.||..||.||:||...|.|.|||||.  ...|.::..|.||.....|:::..|
  Rat   177 VAGCLSVGSPVYFRSGAQEFGEPGWWKLV--HNRPPTMRPEGEKLSASTLKVKASKPTLDPIITV 239

  Fly   203 --------RLPAADETSCSSEISVADHAQD----------------------------NPPLI-- 229
                    |.|.........:.|....|:|                            .|.:|
  Rat   240 EGLRKRASRNPVESAMELKEKRSRTQEAKDIRRAQKEAAGLLDRSTSSTPVKFISRGRRPDMILE 304

  Fly   230 KAEAEKPSSTEGCARTIPYMGRLPKIQTQPSPLSQETLPGPPILQENIAPPSQKEEEPQNQPMSM 294
            |.|....||.....||       |.....|||....:.||.|  ..:.|.||...|
  Rat   305 KGEVIDFSSLSSSDRT-------PLTSPSPSPSLDFSAPGTP--ASHSATPSLLSE--------- 351

  Fly   295 VQAGLMDFLAESLESDDFTMFGNLPGIMPPPLIGAGKNDFFMTEPLLH--APLNNEGLFDMDTNF 357
              |.|                  :|.:|||             :.|.|  ..|..:|:.|....:
  Rat   352 --ADL------------------IPDVMPP-------------QALFHDDDELEGDGVIDPGMEY 383

  Fly   358 AIPNTADETKPISTEEPAAESSEEQKEGEVEDEKPE--EDESPDYQPRIVQVTNYQAQEANESIK 420
            ..|.....:..:.:.:....:.:.::|.:.|:|||:  :.:|.|             .::|.|:.
  Rat   384 IPPPAGSASGLMGSRKKVRAAEQIKQEVDSEEEKPDRMDGDSED-------------TDSNTSLH 435

  Fly   421 EEPLEEIMQDDDVTTNSKSSILEPCKPSGFVRQPRRNWPWLQEAQDPDDMAIPSENLKLINAYEE 485
            ....|:          .|..:.:..||.|    ||..               |      ::.|||
  Rat   436 TRAREK----------RKPPLEKDTKPKG----PRYT---------------P------VSIYEE 465

  Fly   486 QKLYQRLDRIFALEHQC--HISIPAYVRRLYRKLSLRKWKRDHNRHIFNLDEHID---------- 538
            :.|.:||:       .|  .:::....|||.|||.:|:.|||....:|:|||.::
  Rat   466 KLLLKRLE-------ACPGAVAMTPEARRLKRKLIVRQAKRDRGLPLFDLDEVVNAALLLVDGIY 523

  Fly   539 ----------PLGRARLKMLGHQKAEILDRYQLLAHSRQDAR---SSFHARLAGCTQYELFE--- 587
                      |.|:|..:.. .|...||||||....:|:..|   :.|..||.|.....:.:
  Rat   524 GAKDGGASRLPAGQATYRTT-CQDFRILDRYQTALPARKGFRHQTTRFLYRLVGSEDLAVDQSIV 587

  Fly   588 SPYSQRVLHPFIFRSETMAPPWLKLMCELQHRVNGSHP-----TRSTIDFCFVRPQHIPAVNALL 647
            |||:.|:|.|:|.|.....||.|:|:.:::..::.|.|     ..:.:|:|:|||.|||.:|::.
  Rat   588 SPYTSRILKPYIRRDYETKPPKLQLLSQIRSHLHKSDPHWTPEPDAPLDYCYVRPNHIPTINSMC 652

  Fly   648 QSTFWPNIDVSECLSYPDYSVVALYKKLVIGCGFLVPDVGYNEAYISFMAVRPCWQRSGIASFML 712
            |..|||.||:||||.|||:|||.||||:::..||:||||.||||||||:.|.|.|:|:|||:||:
  Rat   653 QEFFWPGIDLSECLQYPDFSVVVLYKKVIVAFGFMVPDVKYNEAYISFLLVHPEWRRAGIATFMI 717

  Fly   713 YHLIQTCMSKDITLHVSATNAAVMLYQKFGFKMEEIILDFYDKYLPLDSKQSRNAFFLRLQR 774
            ||||||||.||:||||||:|.|::||||||||.||.:|||||||.||:|.:.::||||||:|
  Rat   718 YHLIQTCMGKDVTLHVSASNPAMLLYQKFGFKTEEYVLDFYDKYYPLESTECKHAFFLRLRR 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atac2	NP_609889.1	PHD	14..63	CDD:214584	13/45 (29%)
		rimI	639..753	CDD:273701	77/113 (68%)
		Acetyltransf_1	676..744	CDD:278980	47/67 (70%)
Kat14	NP_001178784.1	Acetyltransf_1	<669..748	CDD:395465	55/78 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343611
Domainoid	1	1.000	180	1.000	Domainoid score	I3424
eggNOG	1	0.900	-	-		E1_COG0456
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	349	1.000	Inparanoid score	I2221
OMA	1	1.010	-	-		QHG46944
OrthoDB	1	1.010	-	-		D1404086at2759
OrthoFinder	1	1.000	-	-		FOG0006920
OrthoInspector	1	1.000	-	-		oto98387
orthoMCL	1	0.900	-	-		OOG6_105880
Panther	1	1.100	-	-	LDO	PTHR20916
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5829
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770