DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atac2 and Kat14

DIOPT Version :9

Sequence 1:	NP_609889.1	Gene:	Atac2 / 35113	FlyBaseID:	FBgn0032691	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_852082.2	Gene:	Kat14 / 228714	MGIID:	1917264	Length:	779	Species:	Mus musculus

Alignment Length:	842	Identity:	267/842 - (31%)
Similarity:	384/842 - (45%)	Gaps:	217/842 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 DDNYLE------CQECRRMVHIKCLPHACTPGDLLGDVFFEFTCVKCVLDKAKESVIPSDLEPIK 81
            |.:::|      |.:|::.:....|....:  .|.||.||.|||..|..|.             |
Mouse    65 DVSWMEEQLSYFCDKCQKWIPASQLREQLS--YLKGDNFFRFTCCDCSADG-------------K 114

  Fly    82 EVIVRQRIPWLLVLTLTLYNLSIKQKGLGHHGFFHWRTHIISFVDKNWNYIFGPNVRRRKQWTGS 146
            |...|.::.|..|:.|.:||||:  :|.|..|:|.|:..|.:|::|:|.::.| |.::...|..:
Mouse   115 EQYERLKLTWQQVVMLAMYNLSL--EGSGRQGYFRWKEDICAFIEKHWTFLLG-NRKKTSTWWST 176

  Fly   147 VSGALSHNSPEYFQSGLDVFQENGWWKLAKPFQTPRSVLKEYEKKQQLRLQMRIEK--------- 202
            |:|.||..||.||:||...|.|.|||||.  ...|.::..|.||.....|:::..|
Mouse   177 VAGCLSVGSPVYFRSGAQEFGEPGWWKLV--HNRPPTMRPEGEKLAASTLKVKASKPTLDPIITV 239

  Fly   203 --------RLPAADETSCSSEISVADHAQD----------------------------NPPLI-- 229
                    |.|.........:.|....|:|                            .|.||
Mouse   240 EGLRKRASRNPVESAMELKEKRSRTQEAKDIRRAQKEAAGLLDRSTSSTPVKFISRGRRPDLILE 304

  Fly   230 KAEAEKPSSTEGCARTIPYMGRLPKIQTQPSPLSQETLPGPPILQENIAPPSQKEEEPQNQPMSM 294
            |.|....||.....||       |.....|||....:.||.|  ..:.|.||...|
Mouse   305 KGEVIDFSSLSSSDRT-------PLTSPSPSPSLDFSAPGTP--ASHSATPSLLSE--------- 351

  Fly   295 VQAGLMDFLAESLESDDFTMFGNLPGIMPPPLIGAGKNDFFMTEPLLH--APLNNEGLFDMDTNF 357
              |.|                  :|.:|||             :.|.|  ..|..:|:.|....:
Mouse   352 --ADL------------------IPDVMPP-------------QALFHDDDELEGDGVIDPGMEY 383

  Fly   358 AIPNTADETKPISTEEPAAESSEEQKEGEVEDEKPE--EDESPDYQPRIVQVTNYQAQEANESIK 420
            ..|.....:..:.:.:......:.::|.:.|:|||:  :.:|.|....|...|  :|:|.    :
Mouse   384 IPPPAGSASGLLGSRKKVRAPEQIKQEVDSEEEKPDRMDGDSEDTDSNISLHT--RAREK----R 442

  Fly   421 EEPLEEIMQDDDVTTNSKSSILEPCKPSGFVRQPRRNWPWLQEAQDPDDMAIPSENLKLINAYEE 485
            :.|||:.|                 ||.|    ||..               |      ::.|||
Mouse   443 KPPLEKDM-----------------KPKG----PRYT---------------P------VSIYEE 465

  Fly   486 QKLYQRLDRIFALEHQC--HISIPAYVRRLYRKLSLRKWKRDHNRHIFNLDEHIDPL-------- 540
            :.|.:||:       .|  .:::....|||.|||.:|:.|||....:|:|||.::..
Mouse   466 KLLLKRLE-------ACPGAVAMTPEARRLKRKLIVRQAKRDRGLPLFDLDEVVNAALLLVDGIY 523

  Fly   541 -----GRARLKMLGH-------QKAEILDRYQLLAHSRQDAR---SSFHARLAGCTQYELFE--- 587
                 |.:|| ..|.       |...||||||....:|:..|   :.|..||.|.....:.:
Mouse   524 GAKDGGASRL-AAGQATYRTTCQDFRILDRYQTALPARKGFRHQTTRFLYRLVGSEDLAVDQSII 587

  Fly   588 SPYSQRVLHPFIFRSETMAPPWLKLMCELQHRVNGSHP-----TRSTIDFCFVRPQHIPAVNALL 647
            |||:.|:|.|:|.|.....||.|:|:.:::..::.|.|     ..:.:|:|:|||.|||.:|::.
Mouse   588 SPYTSRILKPYIRRDYETKPPKLQLLSQIRSHLHRSDPHWTPGPDAPLDYCYVRPNHIPTINSMC 652

  Fly   648 QSTFWPNIDVSECLSYPDYSVVALYKKLVIGCGFLVPDVGYNEAYISFMAVRPCWQRSGIASFML 712
            |..|||.||:||||.|||:|||.||||:::..||:||||.||||||||:.|.|.|:|:|||:||:
Mouse   653 QEFFWPGIDLSECLQYPDFSVVVLYKKVIVAFGFMVPDVKYNEAYISFLLVHPEWRRAGIATFMI 717

  Fly   713 YHLIQTCMSKDITLHVSATNAAVMLYQKFGFKMEEIILDFYDKYLPLDSKQSRNAFFLRLQR 774
            ||||||||.||:||||||:|.|::||||||||.||.:|||||||.||:|.:.::||||||:|
Mouse   718 YHLIQTCMGKDVTLHVSASNPAMLLYQKFGFKTEEYVLDFYDKYYPLESTECKHAFFLRLRR 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atac2	NP_609889.1	PHD	14..63	CDD:214584	13/45 (29%)
		rimI	639..753	CDD:273701	77/113 (68%)
		Acetyltransf_1	676..744	CDD:278980	47/67 (70%)
Kat14	NP_852082.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	247..292		5/44 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	314..345		9/39 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	360..457		27/136 (20%)
		RimI	648..760	CDD:223532	76/111 (68%)
		Acetyltransf_1	680..749	CDD:278980	47/68 (69%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839771
Domainoid	1	1.000	178	1.000	Domainoid score	I3557
eggNOG	1	0.900	-	-		E1_COG0456
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	346	1.000	Inparanoid score	I2304
Isobase	1	0.950	-	0	Normalized mean entropy	S7398
OMA	1	1.010	-	-		QHG46944
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006920
OrthoInspector	1	1.000	-	-		oto94882
orthoMCL	1	0.900	-	-		OOG6_105880
Panther	1	1.100	-	-	LDO	PTHR20916
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10265
SonicParanoid	1	1.000	-	-		X5829
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.740