DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10333 and DDX23

DIOPT Version :9

Sequence 1:	NP_609888.2	Gene:	CG10333 / 35112	FlyBaseID:	FBgn0032690	Length:	822	Species:	Drosophila melanogaster
Sequence 2:	NP_004809.2	Gene:	DDX23 / 9416	HGNCID:	17347	Length:	820	Species:	Homo sapiens

Alignment Length:	846	Identity:	546/846 - (64%)
Similarity:	655/846 - (77%)	Gaps:	59/846 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DKKRRSRS---RERHREDRPAVGNPRDRERERDRVRE----RDRQFDREKERRQRRSRSREDRNR 61
            |||.|..|   .||.|...|      ||||:|||.|:    :||:..|.::||:..|||| .|:|
Human     7 DKKDRDASPSKEERKRSRTP------DRERDRDRDRKSSPSKDRKRHRSRDRRRGGSRSR-SRSR 64

  Fly    62 RRSPERQR---------PRD-NVRERSRERGG--------GAGGGGGGGAEKKAKMDTGDAPPKP 108
            .:|.||:|         .|| |.::|.|::.|        .:....|.|.:.|::.|....
Human    65 SKSAERERRHKERERDKERDRNKKDRDRDKDGHRRDKDRKRSSLSPGRGKDFKSRKDRDSK---- 125

  Fly   109 LIVDDEEQQDGKEAKVKKEPLSLEELLDKKKREEEARSKPVFLTKEQRALEAIKRRQEEV-ERQR 172
               .|||.:.| :.|.|.:||||||||.|||.||||.:||.||:|.:|..||:||||:|| ||||
Human   126 ---KDEEDEHG-DKKPKAQPLSLEELLAKKKAEEEAEAKPKFLSKAEREAEALKRRQQEVEERQR 186

  Fly   173 AAHDAAREQMAAASKVSISMGTAMASGAPPPAIVAPPPKPDRRERGGGRDRGDRIDRGERGDDKR 237
            ...:..:::     |....:|..|         :..|.:.:||||   |:|.:|...|...::.|
Human   187 MLEEERKKR-----KQFQDLGRKM---------LEDPQERERRER---RERMERETNGNEDEEGR 234

  Fly   238 AEDLTHKDKEKELEAIRERYLGIIKKKRRVRRLNDRKFVFDWDAGEDTSIDYNNLYKERHHVQFF 302
            .:....|||.|||.||:|||||.|||:||.|.||||||||:|||.||||||||.||||||.||..
Human   235 QKIREEKDKSKELHAIKERYLGGIKKRRRTRHLNDRKFVFEWDASEDTSIDYNPLYKERHQVQLL 299

  Fly   303 GRGNVAGIDIKEQKRTQSKFYGDLLEKRRTEAEKEQEKVRLKKMKRKEDKQKWDDRHWSEKENDE 367
            |||.:||||:|:|||.||:|||||:|||||..|||||:.||:|:::||.||:|||||||:|:.||
Human   300 GRGFIAGIDLKQQKREQSRFYGDLMEKRRTLEEKEQEEARLRKLRKKEAKQRWDDRHWSQKKLDE 364

  Fly   368 MTERDWRIFREDYNVTIKGGRIPNPIRSWNESGFPKEIIDIIDKVGYKEPTPIQRQAIPIGLQNR 432
            ||:||||||||||::|.|||:||||||||.:|..|..|:::|||.||||||||||||||||||||
Human   365 MTDRDWRIFREDYSITTKGGKIPNPIRSWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNR 429

  Fly   433 DIIGVAETGSGKTLAFLIPLLSWIQSLPKIERLEDVDQGPYAIIMAPTRELAQQIEEETTKFGQP 497
            |||||||||||||.|||||||.||.:||||:|:|:.||||||||:||||||||||||||.|||:|
Human   430 DIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQGPYAIILAPTRELAQQIEEETIKFGKP 494

  Fly   498 LGIRTVVVVGGLSREEQGFRLRLGCEIVIATPGRLIDVLENRYLVLNQCTYIVLDEADRMIDMGF 562
            ||||||.|:||:|||:||||||:|||||||||||||||||||||||::|||:|||||||||||||
Human   495 LGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGF 559

  Fly   563 EPDVQKILEYMPVTNLKPDTEEAEDETKLMENFYT-KKKYRQTVMFTATMPPAVERLARTYLRRP 626
            |||||||||:|||:|.||||:||||..|::.||.: |.|||||||||||||||||||||:|||||
Human   560 EPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRP 624

  Fly   627 ATVYIGSVGKPTERTEQIVYMMGENDKRKKLMEILSRKIDPPVIIFVNQKKGADVLAKGLEKLGY 691
            |.|||||.|||.||.||.|::|.|::|||||:.||.:..|||:|||||||||.|||||.|||:||
Human   625 AVVYIGSAGKPHERVEQKVFLMSESEKRKKLLAILEQGFDPPIIIFVNQKKGCDVLAKSLEKMGY 689

  Fly   692 NSCTLHGGKGQEQREYALAALKSGAKDILVATDVAGRGIDIKDVSLVINYDMAKTIEDYTHRIGR 756
            |:|||||||||||||:||:.||:||||||||||||||||||:|||:|:||||||.||||.|||||
Human   690 NACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGR 754

  Fly   757 TGRAGKTGCAISFVTKDDSALFYDLKQCVSASPVSTCPPELMNHPEAQHKPGTVVTKKRREEKIF 821
            ||||||:|.||:|:||:|||:||:|||.:..||||:|||||.|||:|||||||::|||||||.||
Human   755 TGRAGKSGVAITFLTKEDSAVFYELKQAILESPVSSCPPELANHPDAQHKPGTILTKKRREETIF 819

  Fly   822 A 822
            |
Human   820 A 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10333	NP_609888.2	DEADc	396..629	CDD:238167	190/233 (82%)
		DEXDc	409..632	CDD:214692	188/223 (84%)
		Helicase_C	651..761	CDD:278689	87/109 (80%)
DDX23	NP_004809.2	RS domain	1..221		90/245 (37%)
		PTZ00121	<4..>351	CDD:173412	174/375 (46%)
		SF-CC1	80..>210	CDD:273721	52/151 (34%)
		Q motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00552	391..419		17/27 (63%)
		DEADc_DDX23	402..628	CDD:350703	187/225 (83%)
		DEAD box. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00541	549..552		2/2 (100%)
		SF2_C_DEAD	639..768	CDD:350174	98/128 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160518
Domainoid	1	1.000	382	1.000	Domainoid score	I840
eggNOG	1	0.900	-	-		E2759_KOG0333
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3542
Inparanoid	1	1.050	1045	1.000	Inparanoid score	I263
Isobase	1	0.950	-	0	Normalized mean entropy	S825
OMA	1	1.010	-	-		QHG55082
OrthoDB	1	1.010	-	-		D183201at33208
OrthoFinder	1	1.000	-	-		FOG0003506
OrthoInspector	1	1.000	-	-		oto89681
orthoMCL	1	0.900	-	-		OOG6_102378
Panther	1	1.100	-	-	LDO	PTHR47958
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R991
SonicParanoid	1	1.000	-	-		X3074
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750