Protein Alignment CG10333 and DDX3Y

DIOPT Version :10

• Sequence 1: NP_609888.2
• Gene: CG10333 / 35112
• FlyBaseID: FBgn0032690
• Length: 822
• Species: Drosophila melanogaster
• Sequence 2: NP_004651.2
• Gene: DDX3Y / 8653
• HGNCID: 2699
• Length: 660
• Species: Homo sapiens
• Alignment Length: 701
• Identity: 218/701 - (31%)
• Similarity: 300/701 - (42%)
• Gaps: 178/701 - (25%)

  Fly   161 IKRRQEEVERQRAAHDAAREQMAAASKVSISMGTAMASGAPPPAIVAPPPKPDRRERGGGRDR-- 223
            :.:...|:::|.|..|...|:.:..:..: |.|..:           ||...:|....|..|:
Human     5 VVKNDPELDQQLANLDLNSEKQSGGASTA-SKGRYI-----------PPHLRNREASKGFHDKDS 57

  Fly   224 ---------------GDRIDRG------ERGDDKRA--EDLTHKDKEKELEAIRERYLGIIKKKR 265
                           |.|..||      |||...|.  :|....|           |.||..::|
Human    58 SGWSCSKDKDAYSSFGSRDSRGKPGYFSERGSGSRGRFDDRGRSD-----------YDGIGNRER 111

  Fly   266 ----RVRRLN-----DRKFVFDWDAGEDTSIDYNNLYKERHHVQFFGRGNVAGIDIKEQKRTQSK 321
                |..|..     |:....||......|        ||...:.|..|| .||:.
Human   112 PGFGRFERSGHSRWCDKSVEDDWSKPLPPS--------ERLEQELFSGGN-TGINF--------- 158

  Fly   322 FYGDLLEKRRTEAEKEQEKVRLKKMKRKEDKQKWDDRHWSEKENDEMTERDWRIFREDYNVTIKG 386
                                           :|:|                      |..|...|
Human   159 -------------------------------EKYD----------------------DIPVEATG 170

  Fly   387 GRIPNPIRSWNESGFPKEIIDIIDKVGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTLAFLIP 451
            ...|..|.::::....:.|:..|:...|..|||:|:.||||....||::..|:||||||.|||:|
Human   171 SNCPPHIENFSDIDMGEIIMGNIELTRYTRPTPVQKHAIPIIKGKRDLMACAQTGSGKTAAFLLP 235

  Fly   452 LLSWIQSLPKIERLEDV---------DQGPYAIIMAPTRELAQQIEEETTKFGQPLGIRTVVVVG 507
            :||.|.:....|.|:.|         .|.|.::::|||||||.||.||..||.....:|..||.|
Human   236 ILSQIYTDGPGEALKAVKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYG 300

  Fly   508 GLSREEQGFRLRLGCEIVIATPGRLIDVLENRYLVLNQCTYIVLDEADRMIDMGFEPDVQKILEY 572
            |....:|...|..||.:::||||||:|::|...:.|:.|.|:||||||||:||||||.:::|:|.
Human   301 GADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQ 365

  Fly   573 --MPVTNLKPDTEEAEDETKLMENFYTKKKYRQTVMFTATMPPAVERLARTYLRRPATVYIGSVG 635
              ||                       .|..|.|:||:||.|..::.|||.:|.....:.:|.||
Human   366 DTMP-----------------------PKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVG 407

  Fly   636 KPTERTEQIVYMMGENDKRKKLMEIL-SRKIDPPVIIFVNQKKGADVLAKGLEKLGYNSCTLHGG 699
            ..:|...|.|..:.:.|||..|::|| :...|...::||..|||||.|...|...||...::||.
Human   408 STSENITQKVVWVEDLDKRSFLLDILGATGSDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGD 472

  Fly   700 KGQEQREYALAALKSGAKDILVATDVAGRGIDIKDVSLVINYDMAKTIEDYTHRIGRTGRAGKTG 764
            :.|..||.||...:||...|||||.||.||:||.:|..|||:|:...||:|.||||||||.|..|
Human   473 RSQRDREEALHQFRSGKSPILVATAVAARGLDISNVRHVINFDLPSDIEEYVHRIGRTGRVGNLG 537

  Fly   765 CAISF-------VTKDDSALFYDLKQCVSASPVSTCPPELMNHPEAQHKPG 808
            .|.||       :|||...|..:.||.|        |..|.|.....|..|
Human   538 LATSFFNEKNMNITKDLLDLLVEAKQEV--------PSWLENMAYEHHYKG 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10333	NP_609888.2	DUF5401	<66..354	CDD:375164	39/226 (17%)
		SrmB	395..783	CDD:440279	164/406 (40%)
DDX3Y	NP_004651.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..121		28/138 (20%)
		DEADc_DDX3	158..408	CDD:350809	104/334 (31%)
		Q motif	178..206		6/27 (22%)
		DEAD box	345..348		2/2 (100%)
		SF2_C_DEAD	413..543	CDD:350174	60/129 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	578..625		1/3 (33%)