Protein Alignment CG10333 and PRP5

DIOPT Version :10

• Sequence 1: NP_609888.2
• Gene: CG10333 / 35112
• FlyBaseID: FBgn0032690
• Length: 822
• Species: Drosophila melanogaster
• Sequence 2: NP_009796.1
• Gene: PRP5 / 852539
• SGDID: S000000441
• Length: 849
• Species: Saccharomyces cerevisiae
• Alignment Length: 743
• Identity: 195/743 - (26%)
• Similarity: 330/743 - (44%)
• Gaps: 170/743 - (22%)

  Fly   133 ELLDKKKREEEARSKPVFLTKEQRALEAIKRRQEEVERQRAAHDAAREQMAAASKVSISMGTAMA 197
            |.:|.|:.           ...:..||..:::..:.::::|..||.:|...:
Yeast     2 ETIDSKQN-----------INRESLLEERRKKLAKWKQKKAQFDAQKEHQTS------------- 42

  Fly   198 SGAPPPAIVAPPPKPDRRERGGGRDRGDRIDRGERGDDKRAEDLTHKDKEKELEAIRERYLGIIK 262
                                     |.|.:.....| .:..|..|.: :|:..|.:|:|.....|
Yeast    43 -------------------------RNDIVTNSLEG-KQTTEKFTER-QERVKEELRKRKNEFRK 80

  Fly   263 ----------KKRRVRRLNDRKFVFDWDAGEDTSIDYNNLYKERHHVQ--------------FFG 303
                      ||:..|....:|..||:...:|:.|..:  ::.:.|:|              |.
Yeast    81 SDEPVSVKPSKKKSKRSKVKKKISFDFSDDDDSEIGVS--FRSKEHIQKAPEHDNEKDPLDEFM- 142

  Fly   304 RGNVAGIDIKEQKRTQSK-FY--GDLL-------EKRRTEAEKEQEK------VRLKKMKRK--- 349
                  ..:||:|.:.|| .|  ||:|       |...|:.|..::.      .::.|:|.|
Yeast   143 ------TSLKEEKMSNSKGMYDRGDILDVEDQLFELGGTDDEDVEDNTDNSNIAKIAKLKAKKRV 201

  Fly   350 -------EDKQKWDDRHWSEKEN----DEMTERDWRIFREDYNVTIKGGRIPNPIRSWNESGFPK 403
                   |:.:.:....:.|.|.    .||...:.|:..:  |:.|||...|.|:..|::.|...
Yeast   202 KQIYYSPEELEPFQKNFYIESETVSSMSEMEVEELRLSLD--NIKIKGTGCPKPVTKWSQLGLST 264

  Fly   404 E-IIDIIDKVGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTLAFLIPLLSWIQSLPKIERLED 467
            : ::.|.:|:.:...||||.||:|..:..||:||:::||||||:::|:|||..:::...:.:.|
Yeast   265 DTMVLITEKLHFGSLTPIQSQALPAIMSGRDVIGISKTGSGKTISYLLPLLRQVKAQRPLSKHE- 328

  Fly   468 VDQGPYAIIMAPTRELAQQIEEETTKFGQ-PLGIRTVVVVGGLSREEQGFRLRLGCEIVIATPGR 531
              .||..:|:|||||||.||.||.|||.: ...||:|...||...::|...|:.|.|||:|||||
Yeast   329 --TGPMGLILAPTRELALQIHEEVTKFTEADTSIRSVCCTGGSEMKKQITDLKRGTEIVVATPGR 391

  Fly   532 LIDVL---ENRYLVLNQCTYIVLDEADRMIDMGFEPDVQKILEYMPVTNLKPDTEEAEDETKLME 593
            .||:|   :.:.|...:.|::|:|||||:.|:||||.:.:|::     .::||
Yeast   392 FIDILTLNDGKLLSTKRITFVVMDEADRLFDLGFEPQITQIMK-----TVRPD------------ 439

  Fly   594 NFYTKKKYRQTVMFTATMPPAVERLARTYLRRPATVYIGSVGKPTERTEQIVYMM-GENDKRKKL 657
                    :|.|:|:||.|..:...|...|..|.::.|.|.|...|..:|...:. .|::|...|
Yeast   440 --------KQCVLFSATFPNKLRSFAVRVLHSPISITINSKGMVNENVKQKFRICHSEDEKFDNL 496

  Fly   658 MEILSRK--------------------IDPPVIIFVNQKKGADVLAKGLEKLGYNSCTLHGGKGQ 702
            ::::..:                    :|...||||:.:...|.::|.|...|..:|.:|.||..
Yeast   497 VQLIHERSEFFDEVQSENDGQSSDVEEVDAKAIIFVSSQNICDFISKKLLNAGIVTCAIHAGKPY 561

  Fly   703 EQREYALAALKSGAKDILVATDVAGRGIDIKDVSLVINYDMAKTIEDYTHRIGRTGRAGKTGCAI 767
            ::|...|...|.....||:.|:|..||:::.:|||||.|:..||...|.|..|||.|..::|.||
Yeast   562 QERLMNLEKFKREKNSILLCTEVLSRGLNVPEVSLVIIYNAVKTFAQYVHTTGRTARGSRSGTAI 626

  Fly   768 SFVTKDDSALFYDLKQCVSASPVSTCPP 795
            :.:..|:.:..|.|.:.:....:....|
Yeast   627 TLLLHDELSGAYILSKAMRDEEIKALDP 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10333	NP_609888.2	DUF5401	<66..354	CDD:375164	46/270 (17%)
		SrmB	395..783	CDD:440279	137/413 (33%)
PRP5	NP_009796.1	DEADc_DDX46	244..468	CDD:350711	92/251 (37%)
		SrmB	255..707	CDD:440279	138/428 (32%)
		KH-I_PRP5_like	749..837	CDD:411902