Protein Alignment CG10333 and PRP28

DIOPT Version :9

• Sequence 1: NP_609888.2
• Gene: CG10333 / 35112
• FlyBaseID: FBgn0032690
• Length: 822
• Species: Drosophila melanogaster
• Sequence 2: NP_010529.3
• Gene: PRP28 / 851830
• SGDID: S000002651
• Length: 588
• Species: Saccharomyces cerevisiae
• Alignment Length: 682
• Identity: 239/682 - (35%)
• Similarity: 348/682 - (51%)
• Gaps: 152/682 - (22%)

  Fly   128 PLSLEEL---LDKKKREEEAR----SKPVFLTKEQRALEAIKRRQEEVERQRAAHDAAREQMAAA 185
            |:.:.:|   ::|||..:|..    |||.||.|::|:.:         ||.:...::.....:.:
Yeast     4 PIDVSQLIAGINKKKGLDENTSGKISKPRFLNKQERSKQ---------ERLKENEESLTPTQSDS 59

  Fly   186 SKVSISMGTAMASGAPPPAIVAPPPKPDRRERGGGRDRGDRIDRGERGDDKRAEDLTHKDKEKEL 250
            :||.|.                   |.:.|:.....:..|
Yeast    60 AKVEIK-------------------KVNSRDDSFFNETND------------------------- 80

  Fly   251 EAIRERYLGIIKKKRRVRRLNDRKFVFDWDAGEDTSIDYNNLYKERHHVQFFGRGNVAGIDIKEQ 315
                        |||...:.|..||.|.|:..|||...|:.:...|..
Yeast    81 ------------KKRNPSKQNGSKFHFSWNESEDTLSGYDPIVSTRAI----------------- 116

  Fly   316 KRTQSKFYGDLLEKRRTEAEKEQEKVRLKKMKRKEDKQKWDDRHWSEKENDEMTERDWRIFREDY 380
                     |||.|.:|              .:...:..:..:||:||...||.||||||.:|||
Yeast   117 ---------DLLWKGKT--------------PKNAAESSYMGKHWTEKSLHEMNERDWRILKEDY 158

  Fly   381 NVTIKGGRIPNPIRSWNESG-FPKEIID-IIDKVGYKEPTPIQRQAIPIGL---QNRDIIGVAET 440
            .:..|||.:.||:|:|.|.. .|::::. ||.::.:..||||||..||...   |.||.:|||.|
Yeast   159 AIVTKGGTVENPLRNWEELNIIPRDLLRVIIQELRFPSPTPIQRITIPNVCNMKQYRDFLGVAST 223

  Fly   441 GSGKTLAFLIP-LLSWIQSLPKIERLEDVDQGPYAIIMAPTRELAQQIEEETTKFGQ------PL 498
            ||||||||:|| |:...:|.|:...|:.:| ||.|:|:||||||.|||::||.|..:      ..
Yeast   224 GSGKTLAFVIPILIKMSRSPPRPPSLKIID-GPKALILAPTRELVQQIQKETQKVTKIWSKESNY 287

  Fly   499 GIRTVVVVGGLSREEQGFRLRLGCEIVIATPGRLIDVLENRYLVLNQCTYIVLDEADRMIDMGFE 563
            ..:.:.:|||.|.||..|.|..||:|::||||||||.|||..||:.|...:||||||:|||:|||
Yeast   288 DCKVISIVGGHSLEEISFSLSEGCDILVATPGRLIDSLENHLLVMKQVETLVLDEADKMIDLGFE 352

  Fly   564 PDVQKILEYMPVTNLKPDTEEAEDETKLMENFYTKKKYRQTVMFTATMPPAVERLARTYLRRP-- 626
            ..|..||     |.:..:.:.|.:              |||:||||||.|.:|::|..|:::|
Yeast   353 DQVTNIL-----TKVDINADSAVN--------------RQTLMFTATMTPVIEKIAAGYMQKPVY 398

  Fly   627 ATVYIGSVGKPTERTEQIV-YMMGENDKRKKLMEILSRKIDPPVIIFVNQKKGADVLAKGLEKLG 690
            ||:.:.:..:|.  .:|:| |...:.||.|||..|:: |.|||:|||:|.|:.||.||:..:|..
Yeast   399 ATIGVETGSEPL--IQQVVEYADNDEDKFKKLKPIVA-KYDPPIIIFINYKQTADWLAEKFQKET 460

  Fly   691 YNSCT-LHGGKGQEQREYALAALKSGAKDILVATDVAGRGIDIKDVSLVINYDMAKTIEDYTHRI 754
            ....| |||.|.|||||::|...::....|::||:||.||:||.:||||:|:.::|.::||.|||
Yeast   461 NMKVTILHGSKSQEQREHSLQLFRTNKVQIMIATNVAARGLDIPNVSLVVNFQISKKMDDYIHRI 525

  Fly   755 GRTGRAGKTGCAISFVT-KDDSALFYDLKQCV 785
            ||||||...|.|:|||: .:|.:|..:|.:.|
Yeast   526 GRTGRAANEGTAVSFVSAAEDESLIRELYKYV 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10333	NP_609888.2	DEADc	396..629	CDD:238167	108/246 (44%)
		DEXDc	409..632	CDD:214692	105/234 (45%)
		Helicase_C	651..761	CDD:278689	56/110 (51%)
PRP28	NP_010529.3	SrmB	143..580	CDD:223587	196/438 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346832
Domainoid	1	1.000	152	1.000	Domainoid score	I918
eggNOG	1	0.900	-	-		E2759_KOG0333
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	341	1.000	Inparanoid score	I414
Isobase	1	0.950	-	0	Normalized mean entropy	S825
OMA	1	1.010	-	-		QHG55082
OrthoFinder	1	1.000	-	-		FOG0003506
OrthoInspector	1	1.000	-	-		oto99499
orthoMCL	1	0.900	-	-		OOG6_102378
Panther	1	1.100	-	-	LDO	PTHR47958
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R991
SonicParanoid	1	1.000	-	-		X3074
TreeFam	1	0.960	-	-
	15	14.740