DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10333 and Ddx23

DIOPT Version :9

Sequence 1:	NP_609888.2	Gene:	CG10333 / 35112	FlyBaseID:	FBgn0032690	Length:	822	Species:	Drosophila melanogaster
Sequence 2:	NP_001074450.1	Gene:	Ddx23 / 74351	MGIID:	1921601	Length:	819	Species:	Mus musculus

Alignment Length:	846	Identity:	541/846 - (63%)
Similarity:	649/846 - (76%)	Gaps:	60/846 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DKKRRSRSRERHREDRPAVGNPRDRERERDRVRERDRQFDREKERRQRRSRSR-------EDRNR 61
            |||.|..|.:..|:        |.|..||||.|:|||:....|:|::.|||.|       ..|:|
Mouse     7 DKKDRDASPKEERK--------RSRTPERDRDRDRDRKSSPSKDRKRHRSRDRRRGGSRSRSRSR 63

  Fly    62 RRSPER-----QRPRDNVRERS-RERGGGAGG------------GGGGGAEKKAKMDTGDAPPKP 108
            .:|.||     :|.||..|:|| :||.....|            ..|.|.:.|::.|.....
Mouse    64 SKSVERERRHKERERDKERDRSKKERERDKDGHRRDKDRKRSSLSPGRGKDFKSRKDRDSKK--- 125

  Fly   109 LIVDDEEQQDGKEAKVKKEPLSLEELLDKKKREEEARSKPVFLTKEQRALEAIKRRQEEV-ERQR 172
               .||::...|..|:  :||||||||.|||.||||.:||.||:|.:|..||:||||:|| |||:
Mouse   126 ---GDEDEHGDKRPKI--QPLSLEELLAKKKAEEEAEAKPKFLSKAEREAEALKRRQQEVEERQK 185

  Fly   173 AAHDAAREQMAAASKVSISMGTAMASGAPPPAIVAPPPKPDRRERGGGRDRGDRIDRGERGDDKR 237
            ...:..:::     |....:|..|         :..|.:.:||||   |:|.:|...|...::.|
Mouse   186 MLEEERKKR-----KQFQDLGRKM---------LEDPQERERRER---RERMERETNGNEDEEGR 233

  Fly   238 AEDLTHKDKEKELEAIRERYLGIIKKKRRVRRLNDRKFVFDWDAGEDTSIDYNNLYKERHHVQFF 302
            .:....|||.|||.||:|||||.|||:||.|.||||||||:|||.||||||||.||||||.||..
Mouse   234 QKIREEKDKSKELHAIKERYLGGIKKRRRTRHLNDRKFVFEWDASEDTSIDYNPLYKERHQVQLL 298

  Fly   303 GRGNVAGIDIKEQKRTQSKFYGDLLEKRRTEAEKEQEKVRLKKMKRKEDKQKWDDRHWSEKENDE 367
            |||.:||||:|:|||.||:|||||:|||||..|||||:.||:|:::||.||:|||||||:|:.||
Mouse   299 GRGFIAGIDLKQQKREQSRFYGDLMEKRRTLEEKEQEEARLRKLRKKEAKQRWDDRHWSQKKLDE 363

  Fly   368 MTERDWRIFREDYNVTIKGGRIPNPIRSWNESGFPKEIIDIIDKVGYKEPTPIQRQAIPIGLQNR 432
            ||:||||||||||::|.|||:||||||||.:|..|..|:::|||.||||||||||||||||||||
Mouse   364 MTDRDWRIFREDYSITTKGGKIPNPIRSWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNR 428

  Fly   433 DIIGVAETGSGKTLAFLIPLLSWIQSLPKIERLEDVDQGPYAIIMAPTRELAQQIEEETTKFGQP 497
            |||||||||||||.|||||||.||.:||||:|:|:.||||||||:||||||||||||||.|||:|
Mouse   429 DIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQGPYAIILAPTRELAQQIEEETIKFGKP 493

  Fly   498 LGIRTVVVVGGLSREEQGFRLRLGCEIVIATPGRLIDVLENRYLVLNQCTYIVLDEADRMIDMGF 562
            ||||||.|:||:|||:||||||:|||||||||||||||||||||||::|||:|||||||||||||
Mouse   494 LGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGF 558

  Fly   563 EPDVQKILEYMPVTNLKPDTEEAEDETKLMENFYT-KKKYRQTVMFTATMPPAVERLARTYLRRP 626
            |||||||||:|||:|.||||:||||..|::.||.: |.|||||||||||||||||||||:|||||
Mouse   559 EPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRP 623

  Fly   627 ATVYIGSVGKPTERTEQIVYMMGENDKRKKLMEILSRKIDPPVIIFVNQKKGADVLAKGLEKLGY 691
            |.|||||.|||.||.||.|::|.|::|||||:.||.:..|||:|||||||||.|||||.|||:||
Mouse   624 AVVYIGSAGKPHERVEQKVFLMSESEKRKKLLAILEQGFDPPIIIFVNQKKGCDVLAKSLEKMGY 688

  Fly   692 NSCTLHGGKGQEQREYALAALKSGAKDILVATDVAGRGIDIKDVSLVINYDMAKTIEDYTHRIGR 756
            |:|||||||||||||:||:.||:||||||||||||||||||:|||:|:||||||.||||.|||||
Mouse   689 NACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGR 753

  Fly   757 TGRAGKTGCAISFVTKDDSALFYDLKQCVSASPVSTCPPELMNHPEAQHKPGTVVTKKRREEKIF 821
            ||||||:|.||:|:||:|||:||:|||.:..||||:|||||.|||:|||||||::|||||||.||
Mouse   754 TGRAGKSGVAITFLTKEDSAVFYELKQAILESPVSSCPPELANHPDAQHKPGTILTKKRREETIF 818

  Fly   822 A 822
            |
Mouse   819 A 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10333	NP_609888.2	DEADc	396..629	CDD:238167	190/233 (82%)
		DEXDc	409..632	CDD:214692	188/223 (84%)
		Helicase_C	651..761	CDD:278689	87/109 (80%)
Ddx23	NP_001074450.1	SF-CC1	79..>207	CDD:273721	50/149 (34%)
		DUF5401	<163..350	CDD:375164	107/203 (53%)
		DEADc_DDX23	401..627	CDD:350703	187/225 (83%)
		SF2_C_DEAD	638..767	CDD:350174	98/128 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850866
Domainoid	1	1.000	379	1.000	Domainoid score	I847
eggNOG	1	0.900	-	-		E2759_KOG0333
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3542
Inparanoid	1	1.050	1042	1.000	Inparanoid score	I266
Isobase	1	0.950	-	0	Normalized mean entropy	S825
OMA	1	1.010	-	-		QHG55082
OrthoDB	1	1.010	-	-		D183201at33208
OrthoFinder	1	1.000	-	-		FOG0003506
OrthoInspector	1	1.000	-	-		oto93249
orthoMCL	1	0.900	-	-		OOG6_102378
Panther	1	1.100	-	-	LDO	PTHR47958
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R991
SonicParanoid	1	1.000	-	-		X3074
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750