DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10333 and ddx23

DIOPT Version :9

Sequence 1:	NP_609888.2	Gene:	CG10333 / 35112	FlyBaseID:	FBgn0032690	Length:	822	Species:	Drosophila melanogaster
Sequence 2:	NP_001017213.2	Gene:	ddx23 / 549967	XenbaseID:	XB-GENE-986212	Length:	806	Species:	Xenopus tropicalis

Alignment Length:	839	Identity:	545/839 - (64%)
Similarity:	654/839 - (77%)	Gaps:	55/839 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VNDKKRR--SRSRERHREDRPAVGNPRDRERERDRVRE----RDRQFDREKERRQRRSRSR---- 56
            :.||:.|  |.|:||.|.        |.|..||||.|:    :||:..|.:|||:.|||||
Frog     5 LTDKRDRDGSPSKERKRS--------RSRSAERDRDRKSSPSKDRKRHRSRERRRSRSRSRSRSK 61

  Fly    57 -EDRNRR---RSPERQRPRDNVR---ERSRERGGGAGGGGGGGAEKKAKMDTGDAPPKPLIVDDE 114
             .:|:||   |..:|:|.:|..|   ||.|.|......|.....:|:.|.:          |::|
Frog    62 SNERDRRQKDRKKDREREKDTHRRDKERKRSRSVSPNRGKETKVKKEVKKE----------VEEE 116

  Fly   115 EQQDGKEAKVKKEPLSLEELLDKKKREEEARSKPVFLTKEQRALEAIKRRQEEVERQRAAHDAAR 179
            ||.| |::||  .||||||||.|||:||||.|||.||:|.:|..||:||||.:||.:::..:..|
Frog   117 EQTD-KKSKV--NPLSLEELLAKKKKEEEAESKPKFLSKAEREAEALKRRQMQVEERQSLLEEER 178

  Fly   180 EQMAAASKVSISMGTAMASGAPPPAIVAPPPKPDRRERGGGRDRGDRIDRGERGDDKRAEDLTHK 244
            ::.....:....|             :..|.:.:||||   |:|.:|.:.|...|:.|.:....|
Frog   179 KKRKHFQETGRRM-------------LEDPQERERRER---RERIERENNGNEDDEGRIKVREEK 227

  Fly   245 DKEKELEAIRERYLGIIKKKRRVRRLNDRKFVFDWDAGEDTSIDYNNLYKERHHVQFFGRGNVAG 309
            ||.|||:||:|||||.:||:||.|.||||||||:|||.||||||||.||||||.||..|||.:||
Frog   228 DKTKELQAIKERYLGGLKKRRRTRHLNDRKFVFEWDASEDTSIDYNPLYKERHQVQLLGRGFIAG 292

  Fly   310 IDIKEQKRTQSKFYGDLLEKRRTEAEKEQEKVRLKKMKRKEDKQKWDDRHWSEKENDEMTERDWR 374
            ||:|:|||.||:|||||:|||||..|||||:|||:|:::||.||:|||||||:|:.||||:||||
Frog   293 IDLKQQKREQSRFYGDLMEKRRTLEEKEQEEVRLRKLRKKEAKQRWDDRHWSQKKLDEMTDRDWR 357

  Fly   375 IFREDYNVTIKGGRIPNPIRSWNESGFPKEIIDIIDKVGYKEPTPIQRQAIPIGLQNRDIIGVAE 439
            ||||||::|.|||:||||||||.:|..|..|:::|||.|||||||||||||||||||||||||||
Frog   358 IFREDYSITTKGGKIPNPIRSWVDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAE 422

  Fly   440 TGSGKTLAFLIPLLSWIQSLPKIERLEDVDQGPYAIIMAPTRELAQQIEEETTKFGQPLGIRTVV 504
            ||||||.|||||||.||.:||||:|:|:.||||||||:||||||||||||||.|||:|||||||.
Frog   423 TGSGKTAAFLIPLLVWITTLPKIDRIEESDQGPYAIILAPTRELAQQIEEETIKFGKPLGIRTVA 487

  Fly   505 VVGGLSREEQGFRLRLGCEIVIATPGRLIDVLENRYLVLNQCTYIVLDEADRMIDMGFEPDVQKI 569
            |:||:|||:||||||:|||||||||||||||||||||||::|||:||||||||||||||||||||
Frog   488 VIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKI 552

  Fly   570 LEYMPVTNLKPDTEEAEDETKLMENFYT-KKKYRQTVMFTATMPPAVERLARTYLRRPATVYIGS 633
            ||:|||||.||||:||||..|:..||.: |.|||||||||||||||||||||:||||||.|||||
Frog   553 LEHMPVTNQKPDTDEAEDPEKMTANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGS 617

  Fly   634 VGKPTERTEQIVYMMGENDKRKKLMEILSRKIDPPVIIFVNQKKGADVLAKGLEKLGYNSCTLHG 698
            .|||.||.||.|::|.|.:|||||:.||.:..|||:|||||||||.|||||.|||:|||:|||||
Frog   618 AGKPHERVEQKVFLMSEAEKRKKLLAILEKGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHG 682

  Fly   699 GKGQEQREYALAALKSGAKDILVATDVAGRGIDIKDVSLVINYDMAKTIEDYTHRIGRTGRAGKT 763
            ||||||||:||:.||:||||||||||||||||||:|||:|:||||||.||||.|||||||||||:
Frog   683 GKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKS 747

  Fly   764 GCAISFVTKDDSALFYDLKQCVSASPVSTCPPELMNHPEAQHKPGTVVTKKRREEKIFA 822
            |.||:|:||:||::||||||.:..||||:|||||.|||:|||||||::|||||||.|||
Frog   748 GVAITFLTKEDSSVFYDLKQAILESPVSSCPPELANHPDAQHKPGTILTKKRREETIFA 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10333	NP_609888.2	DEADc	396..629	CDD:238167	191/233 (82%)
		DEXDc	409..632	CDD:214692	189/223 (85%)
		Helicase_C	651..761	CDD:278689	87/109 (80%)
ddx23	NP_001017213.2	U2AF_lg	7..>99	CDD:273727	38/99 (38%)
		DEADc_DDX23	388..614	CDD:350703	188/225 (84%)
		SF2_C_DEAD	625..754	CDD:350174	98/128 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	387	1.000	Domainoid score	I799
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1051	1.000	Inparanoid score	I259
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D183201at33208
OrthoFinder	1	1.000	-	-		FOG0003506
OrthoInspector	1	1.000	-	-		oto103497
Panther	1	1.100	-	-	LDO	PTHR47958
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3074
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160