DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10333 and DDX49

DIOPT Version :9

Sequence 1:	NP_609888.2	Gene:	CG10333 / 35112	FlyBaseID:	FBgn0032690	Length:	822	Species:	Drosophila melanogaster
Sequence 2:	NP_061943.2	Gene:	DDX49 / 54555	HGNCID:	18684	Length:	483	Species:	Homo sapiens

Alignment Length:	398	Identity:	132/398 - (33%)
Similarity:	207/398 - (52%)	Gaps:	50/398 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   398 ESGFPKEIIDIIDKVGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTLAFLIPLLSWIQSLPKI 462
            |.|....:::...::|.|:|||:|...||..|:.||.:|.|:||||||.||::|:|
Human     6 ELGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPIL--------- 61

  Fly   463 ERLEDVDQGPYAIIMAPTRELAQQIEEETTKFGQPLGIRTVVVVGGLSREEQGFRLRLGCEIVIA 527
            ::|.:...|.:.:::.||||||.||.|:....|:|||::..::|||:....|...|.....:|||
Human    62 QKLSEDPYGIFCLVLTPTRELAYQIAEQFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIA 126

  Fly   528 TPGRLIDVL-ENRYLVLNQCTYIVLDEADRMIDMG---FEPDVQKILEYMPVTNLKPDTEEAEDE 588
            |||||.|.| .:....:.:..::|:|||||:::.|   |..|::.||..:|..
Human   127 TPGRLADHLRSSNTFSIKKIRFLVMDEADRLLEQGCTDFTVDLEAILAAVPAR------------ 179

  Fly   589 TKLMENFYTKKKYRQTVMFTATMPPAVERLARTYLRRP----ATVYIGSVGKPTERTEQIVYMMG 649
                         |||::|:||:...:..|......:|    |...:.:|    |:.:|...::.
Human   180 -------------RQTLLFSATLTDTLRELQGLATNQPFFWEAQAPVSTV----EQLDQRYLLVP 227

  Fly   650 ENDKRKKLMEILSRKIDP----PVIIFVNQKKGADVLAKGLEKLGYNSCTLHGGKGQEQREYALA 710
            |..|...|:.::.|..|.    .:|||.|..|...:|...|.|..:.:..||....|::|..|||
Human   228 EKVKDAYLVHLIQRFQDEHEDWSIIIFTNTCKTCQILCMMLRKFSFPTVALHSMMKQKERFAALA 292

  Fly   711 ALKSGAKDILVATDVAGRGIDIKDVSLVINYDMAKTIEDYTHRIGRTGRAGKTGCAISFVTKDDS 775
            ..||....||:|||||.||:||..|.:|||::.....:.|.||:|||.|||:.|.||:.||:.|.
Human   293 KFKSSIYRILIATDVASRGLDIPTVQVVINHNTPGLPKIYIHRVGRTARAGRQGQAITLVTQYDI 357

  Fly   776 ALFYDLKQ 783
            .|.:.:::
Human   358 HLVHAIEE 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10333	NP_609888.2	DEADc	396..629	CDD:238167	76/238 (32%)
		DEXDc	409..632	CDD:214692	74/230 (32%)
		Helicase_C	651..761	CDD:278689	43/113 (38%)
DDX49	NP_061943.2	SrmB	1..467	CDD:223587	132/398 (33%)
		Q motif	2..30		7/23 (30%)
		DEAD box	152..155		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..483
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0333
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810