Protein Alignment CG10333 and DDX41

DIOPT Version :10

• Sequence 1: NP_609888.2
• Gene: CG10333 / 35112
• FlyBaseID: FBgn0032690
• Length: 822
• Species: Drosophila melanogaster
• Sequence 2: NP_057306.2
• Gene: DDX41 / 51428
• HGNCID: 18674
• Length: 622
• Species: Homo sapiens
• Alignment Length: 608
• Identity: 207/608 - (34%)
• Similarity: 321/608 - (52%)
• Gaps: 99/608 - (16%)

  Fly   211 KPDRRERGGGRDRGDRIDRGERGDDKRAEDLTHKDKEKELEAIRERYL---GIIKKKRRVRRLND 272
            :|:|:     |.|.|.:..|  |....|||...:|....:...:.|.|   .:::::|:.....:
Human     5 EPERK-----RARTDEVPAG--GSRSEAEDEDDEDYVPYVPLRQRRQLLLQKLLQRRRKGAAEEE 62

  Fly   273 RKFVFDWDAGEDTSIDYNNLYKERHHVQFFGRGNVAGID----IKEQKRTQSKFYGDLLEKRRTE 333
            ::     |:|.:...|.::       :....:.||:.:|    :||:...:.:   ...||:..|
Human    63 QQ-----DSGSEPRGDEDD-------IPLGPQSNVSLLDQHQHLKEKAEARKE---SAKEKQLKE 112

  Fly   334 AEKEQEKV-------RLKKMKR---KED--KQKWDDRHWSEKENDEMTERDWRIFREDYNVTIKG 386
            .||..|.|       .:|:|.:   .:|  |..|....:....::|..||    .|:.|::.::|
Human   113 EEKILESVAEGRALMSVKEMAKGITYDDPIKTSWTPPRYVLSMSEERHER----VRKKYHILVEG 173

  Fly   387 GRIPNPIRSWNESGFPKEIIDIIDKVGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTLAFLIP 451
            ..||.||:|:.|..||..|:..:.|.|...|||||.|.||..|..||:||:|.|||||||.|.:|
Human   174 DGIPPPIKSFKEMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLP 238

  Fly   452 LLSWI----QSLPKIERLEDVDQGPYAIIMAPTRELAQQ-----------IEEETTKFGQPLGIR 501
            ::.:.    :.||..:|     :|||.:|:.|:||||:|           ::|:::    || :|
Human   239 VIMFCLEQEKRLPFSKR-----EGPYGLIICPSRELARQTHGILEYYCRLLQEDSS----PL-LR 293

  Fly   502 TVVVVGGLSREEQGFRLRLGCEIVIATPGRLIDVLENRYLVLNQCTYIVLDEADRMIDMGFEPDV 566
            ..:.:||:|.:||...:|.|..:::||||||:|:|:.:.:.|:.|.|:.|||||||||||||.|:
Human   294 CALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICRYLALDEADRMIDMGFEGDI 358

  Fly   567 QKILEYMPVTNLKPDTEEAEDETKLMENFYTKKKYRQTVMFTATMPPAVERLARTYLRRPATVYI 631
            :.|..|.                         |..|||::|:||||..::..|::.|.:|.|:.:
Human   359 RTIFSYF-------------------------KGQRQTLLFSATMPKKIQNFAKSALVKPVTINV 398

  Fly   632 GSVGKPTERTEQIVYMMGENDKRKKLMEILSRKIDPPVIIFVNQKKGADVLAKGLEKLGYNSCTL 696
            |..|..:....|.|..:.|..|...|:|.| :|..|||:||..:|...|.:.:.|...|..:..:
Human   399 GRAGAASLDVIQEVEYVKEEAKMVYLLECL-QKTPPPVLIFAEKKADVDAIHEYLLLKGVEAVAI 462

  Fly   697 HGGKGQEQREYALAALKSGAKDILVATDVAGRGIDIKDVSLVINYDMAKTIEDYTHRIGRTGRAG 761
            ||||.||:|..|:.|.:.|.||:|||||||.:|:|...:..||||||.:.||:|.||||||||:|
Human   463 HGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFPAIQHVINYDMPEEIENYVHRIGRTGRSG 527

  Fly   762 KTGCAISFVTK--DDSALFYDLK 782
            .||.|.:|:.|  |:|.|. |||
Human   528 NTGIATTFINKACDESVLM-DLK 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10333	NP_609888.2	DUF5401	<66..354	CDD:375164	33/161 (20%)
		SrmB	395..783	CDD:440279	163/405 (40%)
DDX41	NP_057306.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..39		11/40 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	52..84		4/43 (9%)
		Q motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00552	181..209		11/27 (41%)
		DEADc_DDX41	192..397	CDD:350709	90/239 (38%)
		DEAD box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541	344..347		2/2 (100%)
		SF2_C_DEAD	408..536	CDD:350174	59/128 (46%)