DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10333 and ddx23

DIOPT Version :9

Sequence 1:	NP_609888.2	Gene:	CG10333 / 35112	FlyBaseID:	FBgn0032690	Length:	822	Species:	Drosophila melanogaster
Sequence 2:	NP_956176.1	Gene:	ddx23 / 334283	ZFINID:	ZDB-GENE-030131-6215	Length:	807	Species:	Danio rerio

Alignment Length:	822	Identity:	534/822 - (64%)
Similarity:	646/822 - (78%)	Gaps:	39/822 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KKRRSRSRERHREDRPAVGNPRDRERERDRVRERDRQFDRE---KERRQRRSRSREDRNRRRSPE 66
            |:.|||||||.|:..|.....|.|.|||.|.|.|.:..||:   |::.:.|.|||:||      |
Zfish    21 KRSRSRSRERDRKGSPGRERKRHRSRERKRSRSRSKSPDRDRRLKDKDRDRDRSRKDR------E 79

  Fly    67 RQRPRDNVRERSRERGGGAGGGGGGGAEKKAKMDTGDAPPKPLIVDDEEQQDGKEAKVKKEPLSL 131
            |:|.|   |::.|.:...:........:.|.:.|          |..||:::.::.|.|.:||||
Zfish    80 RERDR---RDKDRSKKSRSASPKSKDLKLKREKD----------VKKEEEEEAEKKKDKVQPLSL 131

  Fly   132 EELLDKKKREEEARSKPVFLTKEQRALEAIKRRQEEVERQRAAHDAAREQMAAASKVSISMGTAM 196
            ||||.|||.||||.|||.||:|.:|..||||||::..|.:|...|..|::    .:|...:|..|
Zfish   132 EELLAKKKAEEEAESKPKFLSKSEREAEAIKRREQVAEERRRQLDEERKK----RRVFQDIGRKM 192

  Fly   197 ASGAPPPAIVAPPPKPDRRERGGGRDRGDRIDRGERGDDKRAEDLTHKDKEKELEAIRERYLGII 261
                     :..|.:.:||||   |:|.:|.:.|...||:|.:....|||.|||.||:|||||.:
Zfish   193 ---------LEDPQERERRER---RERMERENNGNDDDDERQKIREEKDKGKELVAIKERYLGGM 245

  Fly   262 KKKRRVRRLNDRKFVFDWDAGEDTSIDYNNLYKERHHVQFFGRGNVAGIDIKEQKRTQSKFYGDL 326
            ||:||.|.||||||||:|||.||||||||.:|||:|.|..:|||.:||||:|:|||.||:|||||
Zfish   246 KKRRRTRHLNDRKFVFEWDASEDTSIDYNPIYKEKHQVHLYGRGFIAGIDLKQQKRDQSRFYGDL 310

  Fly   327 LEKRRTEAEKEQEKVRLKKMKRKEDKQKWDDRHWSEKENDEMTERDWRIFREDYNVTIKGGRIPN 391
            :|||||..|||||:.||||:::||.||:|||||||:|:.||||:||||||||||::|.|||:|||
Zfish   311 MEKRRTNEEKEQEEQRLKKVRKKEAKQRWDDRHWSQKKLDEMTDRDWRIFREDYSITTKGGKIPN 375

  Fly   392 PIRSWNESGFPKEIIDIIDKVGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTLAFLIPLLSWI 456
            |||:|.|...|..|:::|:|.|||:|||||||||||||||||||||||||||||.|||||||.||
Zfish   376 PIRNWKEYSLPPHILEVIEKCGYKDPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWI 440

  Fly   457 QSLPKIERLEDVDQGPYAIIMAPTRELAQQIEEETTKFGQPLGIRTVVVVGGLSREEQGFRLRLG 521
            .:||||:|:||.||||||||:||||||||||||||.|||:|||||||.|:||:|||:||||||:|
Zfish   441 TTLPKIDRIEDSDQGPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMG 505

  Fly   522 CEIVIATPGRLIDVLENRYLVLNQCTYIVLDEADRMIDMGFEPDVQKILEYMPVTNLKPDTEEAE 586
            ||||||||||||||||||||||::|||:|||||||||||||||||||||||:||||.||||::||
Zfish   506 CEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILEYIPVTNQKPDTDDAE 570

  Fly   587 DETKLMENFYT-KKKYRQTVMFTATMPPAVERLARTYLRRPATVYIGSVGKPTERTEQIVYMMGE 650
            |..|:|:||.: |.|||||||||||||||||||||:||||||.|||||.|||.||.||.|.:|.|
Zfish   571 DPEKMMQNFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVILMSE 635

  Fly   651 NDKRKKLMEILSRKIDPPVIIFVNQKKGADVLAKGLEKLGYNSCTLHGGKGQEQREYALAALKSG 715
            .:|||||:|:|:...:||:|||||||||.|||||.|||:|||:|||||||||||||:||:.||:|
Zfish   636 GEKRKKLLEVLASGFEPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAG 700

  Fly   716 AKDILVATDVAGRGIDIKDVSLVINYDMAKTIEDYTHRIGRTGRAGKTGCAISFVTKDDSALFYD 780
            |||||||||||||||||:|||:|:||||||.||||.|||||||||||:|.|::|:||:||::|||
Zfish   701 AKDILVATDVAGRGIDIQDVSMVLNYDMAKNIEDYIHRIGRTGRAGKSGVAMTFLTKEDSSVFYD 765

  Fly   781 LKQCVSASPVSTCPPELMNHPEAQHKPGTVVTKKRREEKIFA 822
            |||.:..||||||||||.|||:|||||||::|||||||.|||
Zfish   766 LKQAILESPVSTCPPELANHPDAQHKPGTILTKKRREETIFA 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10333	NP_609888.2	DEADc	396..629	CDD:238167	190/233 (82%)
		DEXDc	409..632	CDD:214692	188/223 (84%)
		Helicase_C	651..761	CDD:278689	86/109 (79%)
ddx23	NP_956176.1	DEADc	380..616	CDD:238167	191/235 (81%)
		DEXDc	393..629	CDD:214692	197/235 (84%)
		Helicase_C	637..746	CDD:278689	86/108 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596916
Domainoid	1	1.000	382	1.000	Domainoid score	I791
eggNOG	1	0.900	-	-		E2759_KOG0333
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3542
Inparanoid	1	1.050	1045	1.000	Inparanoid score	I255
OMA	1	1.010	-	-		QHG55082
OrthoDB	1	1.010	-	-		D183201at33208
OrthoFinder	1	1.000	-	-		FOG0003506
OrthoInspector	1	1.000	-	-		oto39895
orthoMCL	1	0.900	-	-		OOG6_102378
Panther	1	1.100	-	-	LDO	PTHR47958
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R991
SonicParanoid	1	1.000	-	-		X3074
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800