DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10333 and rde-12

DIOPT Version :9

Sequence 1:	NP_609888.2	Gene:	CG10333 / 35112	FlyBaseID:	FBgn0032690	Length:	822	Species:	Drosophila melanogaster
Sequence 2:	NP_001256533.1	Gene:	rde-12 / 179855	WormBaseID:	WBGene00010280	Length:	959	Species:	Caenorhabditis elegans

Alignment Length:	854	Identity:	206/854 - (24%)
Similarity:	319/854 - (37%)	Gaps:	212/854 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RSRSRERH-------REDRPAVGNPRDRERERDRVRERDRQFD--REKERRQRRSR-SREDRNRR 62
            ||.||:.|       |:||...|...|     :|..:.:..:|  |..:..||.:. |::||...
Worm    77 RSHSRDNHGGSRYGERDDRGNNGRSAD-----NRYSQSNYNYDSNRGGQHYQRDNHGSKDDRGPM 136

  Fly    63 RSPERQRPRDNVRERSRE-RGGGAGGGGGGGAEKKAKMDTGDAPPKPLIVDDEEQQDGKEAKVKK 126
            ..........|...|:.: |.|...|.|..|..:.               ||..:.|..:|:..:
Worm   137 NQYNDHGSNHNSNSRNDQYRQGSYQGDGHSGYRRD---------------DDRRRNDNDQARPYQ 186

  Fly   127 EPLSLEELLDKKKREEEARSKPVFLTKEQRALEAIKR-RQEEVERQRAAHDAAREQMAAASKVSI 190
            .....:....:......::|.|......|....|.|. .|...:..:..||:.|.|.:...
Worm   187 SNRDSDRNSPRDHHNYNSQSSPRSHQGGQDRYSAPKEDNQRRYDNHQGGHDSYRGQNSGGY---- 247

  Fly   191 SMGTAMASGAPPPAIVAPPPKPDRRERGGGRDRGDRIDRGERGDDKRAEDLTHKDKEKELEAIRE 255
               :...||.......:.....|.|..|.....|.:.|.|..|:|.|.
Worm   248 ---SGNNSGEYRNDYRSQQDSRDHRSGGNNSSSGFKNDGGFGGNDNRG----------------- 292

  Fly   256 RYLGIIKKKRRVRRLNDRKFVFDWDAGEDTSIDYNNLYKERHHVQFFGRGNVAGIDIKEQKRTQS 320
                                 |..:.|.... :.||.|:...:       |:.|.
Worm   293 ---------------------FGNNGGGSFG-NPNNSYRGNSN-------NIGGF---------- 318

  Fly   321 KFYGDLLEKRRTEAEKEQEKVRLKKMKRKEDKQKWDDRHWSEKENDE------MTERDW------ 373
                                                  |.|:..|.|      ...|||
Worm   319 --------------------------------------HRSDGSNSEGVNAPVRAPRDWVPVTRD 345

  Fly   374 --RIFRE------------DYNVTIKGGRIPNPIRSWNESGFPKEIIDIIDKVGYKEPTPIQRQA 424
              .:.||            |..|.|:.......:.||..||....|::.:.::.|.....||...
Worm   346 IDELVRETADRLADCDVGQDRAVEIRNAEKDVRLTSWTNSGLHPTILETLKRIKYNNVRTIQGAM 410

  Fly   425 IPIGLQNRDIIGVAETGSGKTLAFLIPLLSWIQSLPKIERLED-------VDQGPYAIIMAPTRE 482
            ||..|...|::|.|||.:|||.||.:|::.      ||.|:::       .|.||.|:|:|||||
Worm   411 IPQVLDGHDVLGQAETSAGKTAAFGLPIID------KILRMDEETRNKARQDDGPLALILAPTRE 469

  Fly   483 LAQQIEEETTKFGQPLGIRTVVVVGGLSREEQGFRLRLGCEIVIATPGRLIDVLENRYLVLNQCT 547
            ||.||.|....:.|...|..::..|...|......:|.||:|:|.|.||::|.....::.|....
Worm   470 LAAQIHEALRTYCQNTDIIVLLSYGQSDRARSLNEIRNGCDILIGTCGRIMDFTVKSHISLLHLR 534

  Fly   548 YIVLDEADRMIDMGFEPDVQKILEYMPVTNLKPDTEEAEDETKLMENFYTKKKYRQTVMFTATMP 612
            ::|.|||||::.     |::|    .|:.:|....::|    ..||:..|    |||:|.:||..
Worm   535 FLVFDEADRLLQ-----DMKK----DPLGHLGAIIKDA----GFMESAAT----RQTIMTSATFN 582

  Fly   613 PAVERLARTYLRR-PATVYIGSV----GKPTERTE-QIVYMMGENDKRKKLMEILSRKIDP---P 668
            .:|..:|...::| |....:..:    |:.::|.. :.....|..:|..||.|||.:.::.   .
Worm   583 ASVMTVANELMKRLPGQDEMIKIVLANGRLSKRVNLEFFECKGLAEKNAKLREILKQNVNGKTLK 647

  Fly   669 VIIFVNQKKGADVLAKGLEKLGYNSCTLHGGKGQEQREYALAALKSGAKDILVATDVAGRGIDIK 733
            .||||.:|...|..|..|...|..:.||||.:.|:.||..:...||...::||.||:..||||:.
Worm   648 TIIFVQKKDQCDACAAKLTSGGMLAQTLHGDRSQDMREKLINDFKSNRVNLLVTTDLLSRGIDVS 712

  Fly   734 DVSLVINYDMA-----KTIEDYTHRIGRTGRAGK--TGCAISFV---TKDDSALFYDLKQCVSAS 788
            |:..|||:|:.     :..:.:.||.|||||.|:  .|..:|||   :..||.|...|.:.:
Worm   713 DLDRVINFDLPDGDPDQGADTFIHRAGRTGRTGRKENGLCVSFVDPQSDRDSLLAPKLVELI--- 774

  Fly   789 PVSTCPPEL 797
             :|...|:|
Worm   775 -ISQNLPDL 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10333	NP_609888.2	DEADc	396..629	CDD:238167	77/240 (32%)
		DEXDc	409..632	CDD:214692	73/230 (32%)
		Helicase_C	651..761	CDD:278689	44/117 (38%)
rde-12	NP_001256533.1	PTZ00110	230..799	CDD:240273	171/681 (25%)
		P-loop_NTPase	382..594	CDD:304359	75/234 (32%)
		HELICc	628..755	CDD:238034	46/126 (37%)
		Nucleoporin_FG	<867..950	CDD:290362
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47958
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010