Protein Alignment CG10333 and DDX53

DIOPT Version :10

• Sequence 1: NP_609888.2
• Gene: CG10333 / 35112
• FlyBaseID: FBgn0032690
• Length: 822
• Species: Drosophila melanogaster
• Sequence 2: NP_874358.2
• Gene: DDX53 / 168400
• HGNCID: 20083
• Length: 631
• Species: Homo sapiens
• Alignment Length: 684
• Identity: 210/684 - (30%)
• Similarity: 322/684 - (47%)
• Gaps: 139/684 - (20%)

  Fly   214 RRERGGGRDRGDRID-RGERGD--------------DKRAEDLTHK--------------DKEKE 249
            :|.....||.|...| ||.||.              ..|...|..|              .|.|:
Human     9 KRAEANPRDLGASWDVRGSRGSGWSGPFGHQGPRAAGSREPPLCFKIKNNMVGVVIGYSGSKIKD 73

  Fly   250 LEAIRERYLGII--KKKRRVRRLNDRKFVFDWDAGEDTSIDYNNLYKERHHV----------QFF 302
            |:......:.||  :.:.:||...:|:......|..:|.|.....|.....|          :..
Human    74 LQHSTNTKIQIINGESEAKVRIFGNREMKAKAKAAIETLIRKQESYNSESSVDNAASQTPIGRNL 138

  Fly   303 GRGNVAGIDIKEQKRTQSKFYGDLLEKRRTEAEKEQEKVRLKKMKRKEDKQKWDDRHWSEKEN-- 365
            ||.::.|                       |||......|::....:.:|:||.|.. ..|:|
Human   139 GRNDIVG-----------------------EAEPLSNWDRIRAAVVECEKRKWADLP-PVKKNFY 179

  Fly   366 ---------DEMTERDWRIFREDYNVT---IKGGR---IPNPIRSWNES--GFPKEIIDIIDKVG 413
                     .||...:||  :|::|:|   :|.|.   ||.|...:.::  .:| :::..|.:||
Human   180 IESKATSCMSEMQVINWR--KENFNITCDDLKSGEKRLIPKPTCRFKDAFQQYP-DLLKSIIRVG 241

  Fly   414 YKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTLAFLIPLLSWIQSLPKIERLEDVDQGPYAIIMA 478
            ..:|||||.||.||.||..|:|.||:||:||||::|:|....:.|.| |.|  :...||..:::.
Human   242 IVKPTPIQSQAWPIILQGIDLIVVAQTGTGKTLSYLMPGFIHLDSQP-ISR--EQRNGPGMLVLT 303

  Fly   479 PTRELAQQIEEETTKFGQPLGIRTVVVVGGLSREEQGFRLRLGCEIVIATPGRLIDVLENRYLVL 543
            ||||||..:|.|.:|:... |::::.:.||.:|..|...:..|.:|:|||||||.|:..|..:.|
Human   304 PTRELALHVEAECSKYSYK-GLKSICIYGGRNRNGQIEDISKGVDIIIATPGRLNDLQMNNSVNL 367

  Fly   544 NQCTYIVLDEADRMIDMGFEPDVQKILEYMPVTNLKPDTEEAEDETKLMENFYTKKKYRQTVMFT 608
            ...||:|:||||:|:||.|||.::|||     .:::||                    |||||.:
Human   368 RSITYLVIDEADKMLDMEFEPQIRKIL-----LDVRPD--------------------RQTVMTS 407

  Fly   609 ATMPPAVERLARTYLRRPATVYIGSVGKPTERT-EQIVYMMGENDKRKKLMEILSRKIDP--PVI 670
            ||.|..|.:||.:||:.|..||:|::......| :|.:.:..|.:||....|.: ..:.|  .||
Human   408 ATWPDTVRQLALSYLKDPMIVYVGNLNLVAVNTVKQNIIVTTEKEKRALTQEFV-ENMSPNDKVI 471

  Fly   671 IFVNQKKGADVLAKGLEKLGYNSCTLHGGKGQEQREYALAALKSGAKDILVATDVAGRGIDIKDV 735
            :||:||..||.|:......|.::.:|||...|..:|.|:...|||...||:.||:..||:|:.||
Human   472 MFVSQKHIADDLSSDFNIQGISAESLHGNSEQSDQERAVEDFKSGNIKILITTDIVSRGLDLNDV 536

  Fly   736 SLVINYDMAKTIEDYTHRIGRTGRAGKTGCAISFVTKDDSALFYDLKQCVSASPVSTCPPELM-- 798
            :.|.|||..:.|:.|.||:|..||.||||.:::.:|:.||.:..:|.:.:..:..|. |.:|:
Human   537 THVYNYDFPRNIDVYVHRVGYIGRTGKTGTSVTLITQRDSKMAGELIKILDRANQSV-PEDLVVM 600

  Fly   799 ----------NHPEAQ-HKPGTVVTKKRREEKIF 821
                      .|.|.: .|||     :||:|..|
Human   601 AEQYKLNQQKRHRETRSRKPG-----QRRKEFYF 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10333	NP_609888.2	DUF5401	<66..354	CDD:375164	33/180 (18%)
		SrmB	395..783	CDD:440279	148/392 (38%)
DDX53	NP_874358.2	KH-I_DDX43_DDX53	50..115	CDD:411858	13/64 (20%)
		Q motif	222..250		8/28 (29%)
		SrmB	231..625	CDD:440279	157/430 (37%)
		DEAD box	376..379		2/2 (100%)