DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10413 and SLC12A8

DIOPT Version :9

Sequence 1:	NP_001286048.1	Gene:	CG10413 / 35111	FlyBaseID:	FBgn0032689	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_001182412.2	Gene:	SLC12A8 / 84561	HGNCID:	15595	Length:	714	Species:	Homo sapiens

Alignment Length:	418	Identity:	127/418 - (30%)
Similarity:	205/418 - (49%)	Gaps:	51/418 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 GTFAGVFSPVALSMFSALVFIRVGYIVGNAGLYVTLLQFLIAYGIL--LFTVASVCAISTNGAIE 128
            ||:.|||:...:::|..::|:|.|::|||.|  |.|..||:::.||  |.||.|...:....:|.
Human    40 GTWDGVFTSCMINIFGVVLFLRTGWLVGNTG--VLLGMFLVSFVILVALVTVLSGIGVGERSSIG 102

  Fly   129 GGGVYFMISRTLGLEFGGSIGTLFFFANVVGSAMAISGCTEGIMDNFGPRGHFVSGDSHLPDGDW 193
            .||||.|||..||.:.||:||.|:.|...|..||.|:|..|.|.|..|.             |:.
Human   103 SGGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESISDLLGL-------------GNI 154

  Fly   194 WRFLTSSMINTLQLLVCLVGAALFAKTSVIILATVTVCLFATYFSFLFVGATNNTIPVPGDNILS 258
            |.....|    :.:|:.|:|..|.....:|.|..:.:.|.|.......||:..:..|..|
Human   155 WAVRGIS----VAVLLALLGINLAGVKWIIRLQLLLLFLLAVSTLDFVVGSFTHLDPEHG----- 210

  Fly   259 NTTTFLDYTGLNATTLRDNLGSHYGRDYTSNGKQVDFSTTFGVLFSGVTGIMAGANMSGELKNPS 323
                   :.|.:...|::|....|     |.|:  .|.|.|||.|...||:|||.||.|:|:.|:
Human   211 -------FIGYSPELLQNNTLPDY-----SPGE--SFFTVFGVFFPAATGVMAGFNMGGDLREPA 261

  Fly   324 KSIPYGTLSAVAFTFVSYIILSFLMSCTTPYFTMQNNYLFLMPVNLWPPFTAIGILTATFSTSLS 388
            .|||.|:|:||..::..|||..||:........::.::|....|:|......:|:..::.::.:.
Human   262 ASIPLGSLAAVGISWFLYIIFVFLLGAICTREALRYDFLIAEKVSLMGFLFLLGLYISSLASCMG 326

  Fly   389 NLIGSSRILEALSKDQVFGSLLNFVIHGTWKG---NPIAAVAVSWCLVECILLIGSFNIIAQINS 450
            .|.|:.|||:.:::::|..:|   ...|..||   .|:||:.::..:....:.:|..|::|.|.:
Human   327 GLYGAPRILQCIAQEKVIPAL---ACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVT 388

  Fly   451 VLFMLSYLAT-----NLACLGIELTGAP 473
            :.|||:|:|.     :|:.....||..|
Human   389 INFMLTYVAVDYSYFSLSMCSCSLTPVP 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10413	NP_001286048.1	2a30	22..932	CDD:273347	127/418 (30%)
CG10413	NP_001286048.1	SLC12	577..932	CDD:281515
SLC12A8	NP_001182412.2	2a30	35..>407	CDD:273347	124/407 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	471..503
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	530..550
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910