DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10413 and Slc12a9

DIOPT Version :9

Sequence 1:	NP_001286048.1	Gene:	CG10413 / 35111	FlyBaseID:	FBgn0032689	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_001346540.1	Gene:	Slc12a9 / 83704	MGIID:	1933532	Length:	914	Species:	Mus musculus

Alignment Length:	992	Identity:	402/992 - (40%)
Similarity:	544/992 - (54%)	Gaps:	139/992 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ETAPIANSR-SGRTGSVFRSFGSLFGGSQNSGDRPHTPQDGDGYVEFGMQDPDRSGRTLGTFAGV 71
            |::|:...| .|..|:.|                   |.:|.|.  .|:.    |.|.|.||.||
Mouse     4 ESSPLLAYRLLGEEGAAF-------------------PPNGAGV--SGVP----SSRKLSTFLGV 43

  Fly    72 FSPVALSMFSALVFIRVGYIVGNAGLYVTLLQFLIAYGILLFTVASVCAISTNGAIEGGGVYFMI 136
            ..|..|||||.:||:|:|::||:|||...|...|:||.||..||.|||||:||||:.|||.||||
Mouse    44 VVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYIILALTVLSVCAIATNGAVRGGGAYFMI 108

  Fly   137 SRTLGLEFGGSIGTLFFFANVVGSAMAISGCTEGIMDNFGPRGHFVSGDSHLPDGDWWRFLTSSM 201
            |||||.|.|||||.:|:.|||.|.|:::.|..|.|:|.||......||...||.|..|..|..|:
Mouse   109 SRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESILDVFGADATGSSGIQVLPQGYGWNLLYGSL 173

  Fly   202 INTLQLLVCLVGAALFAKTSVIILATVTVCLFATYFSFLFVGATNNTI-PVPGDNILSNTTTFLD 265
            :..|...||.:||.|:|:.|.:....|:..|.:...||:.||..|..: |.||.|..|.......
Mouse   174 LLGLVGGVCTLGAGLYARASFLTFLLVSGSLASVLVSFVAVGPRNIPLAPRPGTNASSVPHRHGH 238

  Fly   266 YTGLNATTLRDNLGSHYGRDYTSNGKQVDFSTTFGVLFSGVTGIMAGANMSGELKNPSKSIPYGT 330
            :||.|.:|||||||:.|..|||: |..:.|::.|.|||:|.||||||||||||||:||::||.||
Mouse   239 FTGFNGSTLRDNLGAGYAEDYTT-GAMMTFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGT 302

  Fly   331 LSAVAFTFVSYIILSFLMSCTTPYFTMQNNYLFLMPVNLWPPFTAIGILTATFSTSLSNLIGSSR 395
            :.|||:||..||:|.||.|.|.....:|.:|.|...::||||...|||.....|.|:|:|||:||
Mouse   303 IIAVAYTFFIYILLFFLSSFTCDRALLQEDYGFFRDISLWPPLVLIGIYATALSASMSSLIGASR 367

  Fly   396 ILEALSKDQVFGSLL--NFVIHGTWKGNPIAAVAVSWCLVECILLIGSFNIIAQINSVLFMLSYL 458
            ||.||::|.:||.:|  ..|:.|  .|||..||..||.||:.:||.|..|.:|.:.:|.::::|.
Mouse   368 ILHALAQDDLFGVILAPAKVVSG--GGNPWGAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYA 430

  Fly   459 ATNLACLGIELTGAPNFRPLFKFFTWHTCLVGLLGTLIMMFVINFIYASSCIILCLILVIALHLF 523
            |.:|:||.:|...||||||.|..|:|||||:|:...|:|||:|:...|...::|..:|..   |.
Mouse   431 AVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGAAGGSLLLMGLLSA---LL 492

  Fly   524 SPATQAAQWGSISQALMFHQVRKYLLMLDPRKDHVKFWRPQILLLVSSPRSCCPLVDFVNDLKKS 588
            :.....:.||.:||||:|||||||||.||.||:||||||||:||||.:||...||:...|.|||.
Mouse   493 TARGGPSSWGYVSQALLFHQVRKYLLRLDVRKEHVKFWRPQLLLLVGNPRGALPLLRLANQLKKG 557

  Fly   589 GLYIIGHVKLGDFKGIEDAEDNQQ---WWSFLDHMRVKAFTEVTLSRSIREGVQHLIRLSGIGAM 650
            |||::|||.|||...:.......|   |.|.:|..:||||.::|||.|:|:|.|||:|:||:|.|
Mouse   558 GLYVLGHVTLGDLDSLPSDPVQPQYGAWLSLVDLAQVKAFVDLTLSPSVRQGAQHLLRISGLGGM 622

  Fly   651 KPNTIILGFYDSEAPRDFF-------------QNGSSPYKTDDFNNGEIQNFPIRRDGDPKQFQI 702
            ||||::|||||...|:|.|             :.|.||..:..|.       |.|..|.|:....
Mouse   623 KPNTLVLGFYDDAPPQDHFLTDPAFSEPAEGTREGGSPALSTLFP-------PPRAPGSPRALSP 680

  Fly   703 QEYVQILCDTLRMKKNLCLCRNF-----QRLDKNFISMSKHVKYIDVWPINIFNPTSGDPF-DMV 761
            |:||..:.|.|:|.||:.|.|..     :||.:. .|.|..:.::||||:|:..|..|..: |:.
Mouse   681 QDYVATVADALKMNKNVVLARACGALPPERLSRG-SSSSAQLHHVDVWPLNLLRPRGGPGYVDVC 744

  Fly   762 SLFMMQLAVI--MLAKWKHLRVRIFLCEANDERTVGTFDTQTPQMEIFSKMKLEQSLKELRITAD 824
            .||::|:|.|  |:..|...|:|||||....|....            ::.:|...|.:|||.|:
Mouse   745 GLFLLQMATILSMVPAWHSARLRIFLCLGPREAPGA------------AEGRLRALLSQLRIRAE 797

  Fly   825 IVEIQEWSRDTDFSRHARTLKQFTAQADNVVLEDDDEVGE-----------ETLNRSLLYMQRAN 878
            :.|: .|....:..                  |.::|.|:           |.|..|      ||
Mouse   798 VQEV-VWGEGAETG------------------EPEEEEGDFVNGGRGDEEAEALACS------AN 837

  Fly   879 QIIR-------------------ERSDQTALSFIYLAAPPKLSAPDFAQRSASYMELLTELTADL 924
            .::|                   |....|||:|:||..||...|     |...|:.||..|:.||
Mouse   838 ALVRAQQGRGTVGGPGGPEGRDGEEGPTTALTFLYLPRPPADPA-----RYPRYLALLETLSRDL 897

  Fly   925 PPTILVHGVSTVTSTTL 941
            .||:|:|||:.||.|.|
Mouse   898 GPTLLIHGVTPVTCTDL 914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10413	NP_001286048.1	2a30	22..932	CDD:273347	390/966 (40%)
CG10413	NP_001286048.1	SLC12	577..932	CDD:281515	130/408 (32%)
Slc12a9	NP_001346540.1	2a30	36..905	CDD:273347	383/924 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	645..678		8/39 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	844..864		1/19 (5%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848620
Domainoid	1	1.000	448	1.000	Domainoid score	I521
eggNOG	1	0.900	-	-		E2759_KOG1288
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5429
Inparanoid	1	1.050	654	1.000	Inparanoid score	I773
Isobase	1	0.950	-	0	Normalized mean entropy	S1765
OMA	1	1.010	-	-		QHG48944
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004225
OrthoInspector	1	1.000	-	-		oto93801
orthoMCL	1	0.900	-	-		OOG6_104998
Panther	1	1.100	-	-	LDO	PTHR11827
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1968
SonicParanoid	1	1.000	-	-		X2970
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740