Protein Alignment CG10413 and slc12a5

DIOPT Version :10

• Sequence 1: NP_609887.1
• Gene: CG10413 / 35111
• FlyBaseID: FBgn0032689
• Length: 941
• Species: Drosophila melanogaster
• Sequence 2: XP_012808003.1
• Gene: slc12a5 / 779759
• XenbaseID: XB-GENE-483436
• Length: 1105
• Species: Xenopus tropicalis
• Alignment Length: 1140
• Identity: 277/1140 - (24%)
• Similarity: 476/1140 - (41%)
• Gaps: 265/1140 - (23%)

  Fly     7 QETAPIANSRSGRTGSVFRSF----------GSLFGGSQN-----SGDRPHTPQDGDGYVEFGMQ 56
            :|::|..||....||.....|          .||..|..|     .|.:.|...:.:   |.|.:
 Frog    23 KESSPFINSSEMDTGKNMALFEEEMDTSPMVSSLLSGLANYTNLTQGVKEHEEAENN---EGGKK 84

  Fly    57 DPDRSGRTLGTFAGVFSPVALSMFSALVFIRVGYIVGNAGLYVTLLQFLIAYGILLFTVASVCAI 121
            .|.::.| :|||.||:.|...::|..::|:|:.::||..|:..:.:..::.....:.|..|:.||
 Frog    85 KPVQAPR-MGTFMGVYLPCLQNIFGVILFLRLTWVVGVGGIMESFIMVVMCCSCTMLTAISMSAI 148

  Fly   122 STNGAIEGGGVYFMISRTLGLEFGGSIGTLFFFANVVGSAMAISGCTEGIMDNFGP-RGHFVSGD 185
            :|||.:..||.|:||||:||.||||::|..|:.......||.|.|..|.::....| ...|::.:
 Frog   149 ATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLTYLFPGMAIFIAQE 213

  Fly   186 SHLPDGDWWRFLTSSMINTLQ-----LLVCL-----VGAALFAKTSVIILATVTVCLFATY---- 236
            :        |...::::|.::     :|.|:     ||.....|.:::.|..|.:.:.|.|
 Frog   214 A--------REEPAALLNNMRVYGTCVLTCMAIVVFVGVKYVNKFALVFLGCVILSIIAIYAGVI 270

  Fly   237 --------FSFLFVGATNNTIPVPGDNILSN------------------TTTFLDYT-------- 267
                    |....:|  |.|:...|.::.:.                  ::.||:.|
 Frog   271 KSAFDPPDFPICLLG--NRTLSRKGFDVCAKFIDSGNETVTTKLWALFCSSPFLNATCDTYFSQN 333

  Fly   268 ---------GLNATTLRDNLGSHY-----------------------GRDYTSNGKQVDFSTTFG 300
                     |:.:..:||||.:.|                       .:.|..:.....|:...|
 Frog   334 NVTEVQGIPGVASGLIRDNLWAGYMQKGIIVEKQGLRSAPNSDALNLDQPYVFSDMTTYFTLLVG 398

  Fly   301 VLFSGVTGIMAGANMSGELKNPSKSIPYGTLSAVAFTFVSYIILSFLMSCTTPYFTMQNNYLFLM 365
            :.|..|||||||:|.||:|::..||||.||:.|:|.|...||....|.........:::.:...:
 Frog   399 IYFPSVTGIMAGSNRSGDLRDAQKSIPIGTIMAIATTSFVYISSVILFGACIEGVVLRDKFGEAV 463

  Fly   366 PVNL------WP-PFT-AIGILTATFSTSLSNLIGSSRILEALSKD------QVFGSLLNFVIHG 416
            ..||      || |:. .||...:|....|.:|.|:.|:|:|:::|      ||||       ||
 Frog   464 NGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQVFG-------HG 521

  Fly   417 TWKGNPIAAVAVSWCLVECILLIGSFNIIAQINSVLFMLSYLATNLACLGIELTGAPNFRPLFKF 481
            ...|.|..|:.::.|:.|..:||.|.:.:|.|.|:.|::.|:..||||....|...||:||.||:
 Frog   522 KANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFKY 586

  Fly   482 FTWHTCLVGLLGTLIMMFVINFIYASSCIILCLILVIALHLFSPATQAAQWGSISQALMFHQVRK 546
            :.|....:|:...|.:||:.::.||   ::...|..:............:||...:.|.....|.
 Frog   587 YHWTLSFLGMSLCLSLMFICSWYYA---LVAMSIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARY 648

  Fly   547 YLLMLDPRKDHVKFWRPQILLLVS--------SPRSCCPLVDFVNDLKK-SGLYIIGHVKLGDFK 602
            .||.|:....|.|.||||:|:||.        .|:    |:...:.||. .||.|:|.|..|.:
 Frog   649 ALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQ----LLSLTSQLKAGKGLTIVGSVVEGTY- 708

  Fly   603 GIED------AEDNQQWWSFLDHMRVKAFTEVTLSRSIREGVQHLIRLSGIGAMKPNTIILGF-- 659
             :|:      ||::.:  ..::..:||.|.:|.:|.:.|:|:.|||:.||:|.::.||:::|:
 Frog   709 -LENHPQCQRAEESIR--RLMEAEKVKGFCKVVISSNTRDGISHLIQSSGLGGLQHNTLLVGWPR 770

  Fly   660 -----YDSEAPRDFFQ-----------------NGSSPYKTDDFNNGEIQNFPIRRDGDPKQFQI 702
                 .|.:..|:|.:                 ....|...:.|:.|.|..:.:..||.
 Frog   771 NWRQKEDHQTWRNFIELVRETTAAHLALIVSKNVAMFPGNLERFSEGNIDVWWVVHDGG------ 829

  Fly   703 QEYVQILCDTLRMKK--NLCLCRNF--QRLDKNFISMSK-------HVKYIDVWPINIFNPTSGD 756
              .:.:|...||..|  ..|..|.|  .::|.|.|.|.|       |:: |:. .:.:......|
 Frog   830 --MLMLLPFLLRHHKVWKRCTMRIFTVAQMDDNSIQMKKDLTTFLYHLR-INA-EVEVVEMHDSD 890

  Fly   757 PFDMVSLFMMQLAVIMLAKWKHLRVRIFLCEANDERTV--------GTFDTQTPQMEIFSKMKLE 813
                :|.:..:..::|..:.:.|: ::.|.:...||.:        |:...:.|     |..:|.
 Frog   891 ----ISAYTYEKTLVMEQRSQILK-QMHLTKTEREREIQSITDESRGSIRRKNP-----SNSRLH 945

  Fly   814 QSLKELRI------TADIVEIQEWSRDTDFSRHAR-----------------TLKQFTAQADNVV 855
            .|:.|.::      :.:.|::......|.||..|:                 |..:.||:.::..
 Frog   946 LSVPEEQVGDCEEKSEEEVQLIHDKNTTGFSESAQSPAEEPDTTQEKVHLTWTKDKCTAEKNSSK 1010

  Fly   856 LEDDDEVGE---------ETLNRSLLYMQ----RANQIIRERSDQTALSFIYLAAPPKLSAPDFA 907
            .....|..:         |.||:|.:...    :.|::|.::|....|..:.:..||:....|
 Frog  1011 CPSTPEAIKDFFNMKPEWENLNQSNVRRMHTAVKLNEVIVKKSHDAKLVLLNMPGPPRNRKGD-- 1073

  Fly   908 QRSASYMELLTELTADLPPTILVHG----VSTVTS 938
               .:|||.|..||..|...:||.|    |.|:.|
 Frog  1074 ---ENYMEFLEVLTEHLDRVMLVRGGGREVITIYS 1105

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10413	NP_609887.1	AA_permease_2	22..932	CDD:459263	267/1113 (24%)
slc12a5	XP_012808003.1	2a30	21..1105	CDD:273347	276/1138 (24%)