DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10413 and Slc12a6

DIOPT Version :9

Sequence 1:	NP_001286048.1	Gene:	CG10413 / 35111	FlyBaseID:	FBgn0032689	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_001103100.1	Gene:	Slc12a6 / 691209	RGDID:	1311335	Length:	1150	Species:	Rattus norvegicus

Alignment Length:	1100	Identity:	284/1100 - (25%)
Similarity:	458/1100 - (41%)	Gaps:	255/1100 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EQETAPIANSRSGRTGSVFRSFGSLFGGSQNSGDRPHTPQDGDGYVEFGMQDPDRSGRTLGTFAG 70
            |.:|.|..:|...|    ..::.:|     ..|.:.|  ::.:...| |.:.|.:|.: :|||.|
  Rat   139 EMDTRPKVSSLLNR----MANYTNL-----TQGAKEH--EEAENITE-GKKKPTKSPQ-MGTFMG 190

  Fly    71 VFSPVALSMFSALVFIRVGYIVGNAGLYVTLLQFLIAYGILLFTVASVCAISTNGAIEGGGVYFM 135
            |:.|...::|..::|:|:.::||.||:.......||.....:.|..|:.||:|||.:..||.|||
  Rat   191 VYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFM 255

  Fly   136 ISRTLGLEFGGSIGTLFFFANVVGSAMAISGCTEGIMDNFGPRGHFVSGDSHLPDGDWWRFLTSS 200
            |||.||.||||::|..|:......:||.|.|..|..:....||......|..|.:       :::
  Rat   256 ISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFRSDDALKE-------SAA 313

  Fly   201 MIN----------TLQLLVCLVGAALFAKTSVIILATVTVCLFATY------------FSFLFVG 243
            |:|          .|.:||..:|.....|.:.:.||.|.|.:.|.|            |....:|
  Rat   314 MLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLG 378

  Fly   244 -----------------ATNNTIPVPGDNILSNTTTFLDYT-----------------GLNATTL 274
                             ..|.|||........|::.|.:.|                 ||.:..:
  Rat   379 NRTLSSRHLDICSKTKEVNNMTIPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGII 443

  Fly   275 RDNLGSHY-------------GRDYTSNGKQ----VDFSTTF----GVLFSGVTGIMAGANMSGE 318
            .:||.|:|             ..|...|...    .|.:|:|    |:.|..|||||||:|.||:
  Rat   444 TENLWSNYLPKGEIIEKPSAKSSDVLGNLNHEYVLADITTSFTLLVGIFFPSVTGIMAGSNRSGD 508

  Fly   319 LKNPSKSIPYGTLSAVAFTFVSYIILSFLMSCTTPYFTMQNNYLFLMPVNL------WP-PFT-A 375
            ||:..||||.||:.|:..|...|:....|.........:::.:...:..||      || |:. .
  Rat   509 LKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIV 573

  Fly   376 IGILTATFSTSLSNLIGSSRILEALSKD------QVFGSLLNFVIHGTWKGNPIAAVAVSWCLVE 434
            ||...:|....|.:|.|:.|:|:|::||      :|||       |....|.|..|:.::..:.|
  Rat   574 IGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFG-------HSKANGEPTWALLLTAAIAE 631

  Fly   435 CILLIGSFNIIAQINSVLFMLSYLATNLACLGIELTGAPNFRPLFKFFTWHTCLVGLLGTLIMMF 499
            ..:||.|.:::|.|.|:.|::.||..||||....|...|::||.|:::.|....:|:...|.:||
  Rat   632 LGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPHWRPRFRYYHWALSFMGMSICLALMF 696

  Fly   500 VINFIYASSCIILCLILVIALHLFSPATQA-AQWGSISQALMFHQVRKYLLMLDPRKDHVKFWRP 563
            :.::.||    |:.:::...::.:.....| .:||...:.|.....|..||.|:....|.|.|||
  Rat   697 ISSWYYA----IVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRP 757

  Fly   564 QILLL--------VSSPRSCCPLVDFVNDLKK-SGLYIIGHVKLGDFKGIEDAEDNQQWWSFLDH 619
            |:|:|        |..||    |:.|.:.||. .||.|:|.|.:|:|  :|:..|.......:.|
  Rat   758 QLLVLLKLDEDLHVKHPR----LLTFASQLKAGKGLTIVGSVIVGNF--LENYGDALAAEQTIKH 816

  Fly   620 M----RVKAFTEVTLSRSIREGVQHLIRLSGIGAMKPNTIILGF-------YDSEAPRDFF---- 669
            :    :||.|.::.::..::||:.|||:..|:|.||.||:::|:       .|:.|.:.|.
  Rat   817 LMEAEKVKGFCQLVVAAKLKEGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVR 881

  Fly   670 ------------QNGS-SPYKTDDFNNGEIQNFPIRRDGDPKQFQIQEYVQILCDTLRMKK--NL 719
                        :|.| .|...:.|:.|.|..:.|..||.        .:.:|...|:..|  ..
  Rat   882 VTTAAHLALLVAKNVSFFPSNVEQFSEGNIDVWWIVHDGG--------MLMLLPFLLKQHKVWRK 938

  Fly   720 CLCRNF--QRLDKNFISMSKHVKYIDVWPINIFNPTSGDPFDMVSLFMMQLAVIMLAKWKHLRV- 781
            |..|.|  .:|:.|.|.|.|                             .||..:.    |||:
  Rat   939 CSIRIFTVAQLEDNSIQMKK-----------------------------DLATFLY----HLRIE 970

  Fly   782 -RIFLCEANDERTVGTFDTQTPQMEIFSKM-------KLE-----QSLKE----LRITA------ 823
             .:.:.|.:|.........:|..||..|:|       |.|     |.:|:    ||:|:
  Rat   971 AEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDED 1035

  Fly   824 -DIVEIQE-----WSRDTDFSRHARTLKQFTAQADNVVLEDDDEVGEETLNRSLLYMQRANQIIR 882
             :....||     |::|...:...:.:|......|.:.:..|     ::..|.:....:.|::|.
  Rat  1036 EETETYQEKVHMTWTKDKYMASRGQKVKSMEGFQDLLNMRPD-----QSNVRRMHTAVKLNEVIV 1095

  Fly   883 ERSDQTALSFIYLAAPPKLSAPDFAQRSASYMELLTELTADLPPTILVHG----VSTVTS 938
            .:|.:..|..:.:..||:....|     .:|||.|..||..|...:||.|    |.|:.|
  Rat  1096 NKSHEAKLVLLNMPGPPRNPEGD-----ENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10413	NP_001286048.1	2a30	22..932	CDD:273347	275/1072 (26%)
CG10413	NP_001286048.1	SLC12	577..932	CDD:281515	95/417 (23%)
Slc12a6	NP_001103100.1	2a30	109..1150	CDD:273347	283/1098 (26%)
		SLC5-6-like_sbd	209..>360	CDD:294310	50/157 (32%)
		SLC12	774..1150	CDD:281515	100/432 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352204
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840