DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10413 and SLC12A4

DIOPT Version :9

Sequence 1:	NP_001286048.1	Gene:	CG10413 / 35111	FlyBaseID:	FBgn0032689	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_001139434.1	Gene:	SLC12A4 / 6560	HGNCID:	10913	Length:	1087	Species:	Homo sapiens

Alignment Length:	1121	Identity:	288/1121 - (25%)
Similarity:	458/1121 - (40%)	Gaps:	285/1121 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSASAEQETAPIANSRSGRTGSVFRSFGSLFGGSQNSGDRPHTPQDGDGYVEFGMQDPDRSGRTL 65
            |:.:.|.:..|..:|..|:    ..|:.:|..|::...:    .:.|:|......:.|     ::
Human    69 MTRTEELDIRPKVSSLLGK----LVSYTNLTQGAKEHEE----AESGEGTRRRAAEAP-----SM 120

  Fly    66 GTFAGVFSPVALSMFSALVFIRVGYIVGNAGLYVTLLQFLIAYGILLFTVASVCAISTNGAIEGG 130
            ||..||:.|...::|..::|:|:.::||.||:...||..||.....|.|..|:.||:|||.:..|
Human   121 GTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAG 185

  Fly   131 GVYFMISRTLGLEFGGSIGTLFFFANVVGSAMAISGCTEGIMDNFG-PRGHFVSGDSHLPDGDWW 194
            |.||||||:||.||||::|..|:......:||.|.|..|.::.... |...|....:|
Human   186 GSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAH------- 243

  Fly   195 RFLTSSMIN----------TLQLLVCLVGAALFAKTSVIILATVTVCLFATY------------F 237
             ..:::.:|          |...||..||.....|.:.:.||.|.:.:.:.|            |
Human   244 -DTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVF 307

  Fly   238 SFLFVG-----------------ATNNTIP------------VPGDN-----ILSNTTTFLDYTG 268
            ....:|                 ..|.|:.            :..|:     :|:|.|......|
Human   308 PVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPG 372

  Fly   269 LNATTLRDNLGSHY---GRDYTSNG---------KQ-------VDFSTTF----GVLFSGVTGIM 310
            ..|..|::||.|.|   |.....:|         |:       .|.:|:|    |:.|..|||||
Human   373 AAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPSVTGIM 437

  Fly   311 AGANMSGELKNPSKSIPYGTLSAVAFTFVSYIILSFLMSCTTPYFTMQNNYLFLMPVNL------ 369
            ||:|.||:|::..||||.||:.|:..|.:.|.....|.........:::.|...:..||
Human   438 AGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLA 502

  Fly   370 WP-PFT-AIGILTATFSTSLSNLIGSSRILEALSKD------QVFGSLLNFVIHGTWKGNPIAAV 426
            || |:. .||...:|....|.:|.|:.|:|:|::||      :|||       ||...|.|..|:
Human   503 WPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFG-------HGKVNGEPTWAL 560

  Fly   427 AVSWCLVECILLIGSFNIIAQINSVLFMLSYLATNLACLGIELTGAPNFRPLFKFFTWHTCLVGL 491
            .::..:.|..:||.|.:::|.|.|:.|::.||..||||....|...||:||.||::.|....:|:
Human   561 LLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGM 625

  Fly   492 LGTLIMMFVINFIYASSCIILCLILVIALHLFSPATQAAQWGSISQALMFHQVRKYLLMLDPRKD 556
            ...|.:|||.::.||   ::..||..:............:||...:.|.....|..||.|:....
Human   626 SLCLALMFVSSWYYA---LVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPP 687

  Fly   557 HVKFWRPQILLL--------VSSPRSCCPLVDFVNDLKK-SGLYIIGHVKLGDF-KGIEDAEDNQ 611
            |.|.||||:|:|        |..||    |:.|.:.||. .||.|:|.|..|.| :...:|:..:
Human   688 HTKNWRPQLLVLLKLDEDLHVKYPR----LLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAE 748

  Fly   612 QW-WSFLDHMRVKAFTEVTLSRSIREGVQHLIRLSGIGAMKPNTIILGFYDSEAPRDFFQNGSSP 675
            |. .:.::..:||.|.:|.::..:|||:.|||:..|:|.|:.|:::||:               |
Human   749 QTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGW---------------P 798

  Fly   676 YKTDDFNNGEIQNFPIRRDGDPKQFQIQEYVQILCDTLRMKKNLCLCRNFQRL----DKNF-ISM 735
            |..             |:..||:.:      :...||:|       |.....|    .||. ...
Human   799 YGW-------------RQSEDPRAW------KTFIDTVR-------CTTAAHLALLVPKNIAFYP 837

  Fly   736 SKHVKY----IDVWPINIFNPTSGDPFDMVSLFMMQLAVIMLAKWKHLRVRIFLCEANDERTVGT 796
            |.|.:|    ||||.|    ...|....::...:.|..|     |:..|:|||        ||..
Human   838 SNHERYLEGHIDVWWI----VHDGGMLMLLPFLLRQHKV-----WRKCRMRIF--------TVAQ 885

  Fly   797 FDTQTPQMEIFSKMKLEQSLKELRITADIVEIQEWSRDTDFSRHARTL----------------- 844
            .|..:.||    |..|...|..||:.|::..::..:.|.....:.|||
Human   886 MDDNSIQM----KKDLAVFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKT 946

  Fly   845 -----------KQFTAQADNVVLEDDDE--VGEETLN----------------------RSLLYM 874
                       :....:.:::..:::||  ||.:.:.                      |.|:::
Human   947 EREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHI 1011

  Fly   875 Q-------------RANQIIRERSDQTALSFIYLAAPPKLSAPDFAQRSASYMELLTELTADLPP 926
            :             :.|::|..||....|..:.:..||:.|..|     .:|||.|..||..|..
Human  1012 KPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGD-----ENYMEFLEVLTEGLER 1071

  Fly   927 TILVHG----VSTVTS 938
            .:||.|    |.|:.|
Human  1072 VLLVRGGGREVITIYS 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10413	NP_001286048.1	2a30	22..932	CDD:273347	279/1088 (26%)
CG10413	NP_001286048.1	SLC12	577..932	CDD:281515	96/431 (22%)
SLC12A4	NP_001139434.1	2a30	70..1087	CDD:273347	286/1118 (26%)
		SLC5-6-like_sbd	144..>305	CDD:294310	51/168 (30%)
		SLC12	711..1087	CDD:281515	101/446 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158233
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840