Protein Alignment CG10413 and SLC12A2

DIOPT Version :10

• Sequence 1: NP_609887.1
• Gene: CG10413 / 35111
• FlyBaseID: FBgn0032689
• Length: 941
• Species: Drosophila melanogaster
• Sequence 2: NP_001037.1
• Gene: SLC12A2 / 6558
• HGNCID: 10911
• Length: 1212
• Species: Homo sapiens
• Alignment Length: 1051
• Identity: 254/1051 - (24%)
• Similarity: 440/1051 - (41%)
• Gaps: 290/1051 - (27%)

  Fly    46 DGDGYVEFGMQDPDRSGRTLGTFAGVFSPVALSMFSALVFIRVGYIVGNAGLYVTLLQFLIAYGI 110
            :..|.|:||.            ..||.....|:::..::|||:.:|||.||:.:::|..::|..:
Human   278 ESKGVVKFGW------------IKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVV 330

  Fly   111 LLFTVASVCAISTNGAIEGGGVYFMISRTLGLEFGGSIGTLFFFANVVGSAMAISGCTEGIMDNF 175
            ...|..|..||:|||.:.|||.|::|||:||.||||:||.:|.|||.|..||.:.|..|.:::..
Human   331 TTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELL 395

  Fly   176 GPRGHFVSGDSHLPDGDWWRFLTSSMINTLQLL-----VCLVGAALF-----AKTSVIILATVTV 230
              :.|.:              |....||.::::     |.|:|.::.     ||..:::|..:.:
Human   396 --KEHSI--------------LMIDEINDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLL 444

  Fly   231 CLFATYFSFLFVGATNNTIPVPGDNILSNTTTFL--------DYTGLNATTLRDNLGSHYGRDYT 287
            .:                    ||.::.   ||:        .:.|..:....:|.|..:..:.|
Human   445 AI--------------------GDFVIG---TFIPLESKKPKGFFGYKSEIFNENFGPDFREEET 486

  Fly   288 SNGKQVDFSTTFGVLFSGVTGIMAGANMSGELKNPSKSIPYGTLSAVAFTFVSYI---------- 342
                   |.:.|.:.|...|||:||||:||:|.:|..:||.|||.|:..|.:.|:
Human   487 -------FFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSCV 544

  Fly   343 -----------ILSFLMSCTTP----------------YFTMQNNYLFLMPVNLWPPFTAIGILT 380
                       |::.|.:||:.                .:.:.||:..:..|:.:.|..:.||.:
Human   545 VRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTPLISAGIFS 609

  Fly   381 ATFSTSLSNLIGSSRILEALSKDQVFGSLLNFVIHGTWKGN-PIAAVAVSWCLVECILLIGSFNI 444
            ||.|::|::|:.:.:|.:||.||.::.:...|. .|..|.| |:....:::.:....:||...|:
Human   610 ATLSSALASLVSAPKIFQALCKDNIYPAFQMFA-KGYGKNNEPLRGYILTFLIALGFILIAELNV 673

  Fly   445 IAQINSVLFMLSYLATNLACLGIELTGAPNFRPLFKFFTWHTCLVGLLGTLIMMFVINFIYASSC 509
            ||.|.|..|:.||...|.:.....|..:|.:||.||::.....|:|.:...|:|||||:..|
Human   674 IAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLGAILCCIVMFVINWWAA--- 735

  Fly   510 IILCLILVIALHLFSPATQA-AQWGSISQALMFHQVRKYLLMLDPRKDHVKFWRPQILLLVSSPR 573
             :|..::|:.|:::....:. ..|||.:|||.:....::.:.|...:||||.:|||.|::..:|.
Human   736 -LLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSGVEDHVKNFRPQCLVMTGAPN 799

  Fly   574 SCCPLVDFVNDLKKS-GLYIIGHVKLGDFKGI--EDAEDNQQWWSFLDHMRVKAFTEVTLSRSIR 635
            |...|:..|:|..|: ||.|.|||.:|..:..  |.:.|..::..:|...::|||.....:..:|
Human   800 SRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMSIDQAKYQRWLIKNKMKAFYAPVHADDLR 864

  Fly   636 EGVQHLIRLSGIGAMKPNTIILGFYDSEAPRDFFQNGSSPYKTDDFNNGEIQNFPIRRDGDPKQF 700
            ||.|:|::.:|:|.|||||::|||     .:|:.|..                   .||
Human   865 EGAQYLMQAAGLGRMKPNTLVLGF-----KKDWLQAD-------------------MRD------ 899

  Fly   701 QIQEYVQILCDTLRMKKNLCLCRNFQRLD--------------------KNFISMSKHVKYID-- 743
             :..|:.:..|...::..:.:.|..:.||                    |:.:...::.|..|
Human   900 -VDMYINLFHDAFDIQYGVVVIRLKEGLDISHLQGQEELLSSQEKSPGTKDVVVSVEYSKKSDLD 963

  Fly   744 ----------------------------------VWPINI-----------FNPTSG-DPFDMVS 762
                                              :.|:|:           |....| :..|:..
Human   964 TSKPLSEKPITHKVEEEDGKTATQPLLKKESKGPIVPLNVADQKLLEASTQFQKKQGKNTIDVWW 1028

  Fly   763 LF-------MMQLAVIMLAKWKHLRVRIFL----------------------CEANDERTVGTFD 798
            ||       ::...:....|||..::|:|:                      .:.:|...:|..:
Human  1029 LFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKINRIDHDRRAMATLLSKFRIDFSDIMVLGDIN 1093

  Fly   799 TQTPQ------MEIFSKMKLEQSLKELRITADIVEIQEWSRDTDFSRHARTLKQFTAQADNVVLE 857
            |:..:      .||....:|.:..||..|...:.|.:.| |.||
Human  1094 TKPKKENIIAFEEIIEPYRLHEDDKEQDIADKMKEDEPW-RITD--------------------- 1136

  Fly   858 DDDEVGEETLNRSLLYMQ-RANQIIRERSDQTALSFIYLAAPPKLSAPDFAQRSASYMELLTELT 921
                 .|..|.::..|.| |.|::::|.|  :..:.|.::.|   .|...|..||.||..|..|:
Human  1137 -----NELELYKTKTYRQIRLNELLKEHS--STANIIVMSLP---VARKGAVSSALYMAWLEALS 1191

  Fly   922 ADLPPTILVHG 932
            .||||.:||.|
Human  1192 KDLPPILLVRG 1202

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10413	NP_609887.1	AA_permease_2	22..932	CDD:459263	253/1049 (24%)
SLC12A2	NP_001037.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..81
		RFXV motif 1. /evidence=ECO:0000269|PubMed:16669787	80..83
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	112..138
		RFXV motif 2. /evidence=ECO:0000269|PubMed:16669787	138..141
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	150..193
		2a30	216..1212	CDD:273347	254/1051 (24%)
		Scissor helix. /evidence=ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7N3N, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7SFL, ECO:0007744|PDB:7SMP	761..778		3/16 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	962..989		0/26 (0%)