DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10413 and SLC12A5

DIOPT Version :9

Sequence 1:	NP_001286048.1	Gene:	CG10413 / 35111	FlyBaseID:	FBgn0032689	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_001128243.1	Gene:	SLC12A5 / 57468	HGNCID:	13818	Length:	1139	Species:	Homo sapiens

Alignment Length:	1186	Identity:	284/1186 - (23%)
Similarity:	462/1186 - (38%)	Gaps:	346/1186 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 QETAPIANSR--------SGRTGSVFRS-------FGSLFGGSQN-----SGDRPHTPQDGDGYV 51
            :|::|..||.        .|:..::|..       ..||..|..|     .|.|.|...:.:
Human    46 KESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENN--- 107

  Fly    52 EFGMQDPDRSGRTLGTFAGVFSPVALSMFSALVFIRVGYIVGNAGLYVTLLQFLIAYGILLFTVA 116
            |.|.:.|.::.| :|||.||:.|...::|..::|:|:.::||.||:..:.....|.....:.|..
Human   108 EGGKKKPVQAPR-MGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAI 171

  Fly   117 SVCAISTNGAIEGGGVYFMISRTLGLEFGGSIGTLFFFANVVGSAMAISGCTEGIMDNFGP---- 177
            |:.||:|||.:..||.|:||||:||.||||::|..|:.......||.|.|..|.::....|
Human   172 SMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAI 236

  Fly   178 -RGHFVSGDSHLPDGDWWRFLTSSMINTLQ-----LLVCL-----VGAALFAKTSVIILA----- 226
             :....||::            ::|:|.::     :|.|:     ||.....|.:::.|.
Human   237 FKAEDASGEA------------AAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILS 289

  Fly   227 ---------------------------------------------TVTVCLFATYFSFLFVGAT- 245
                                                         |||..|:..:.|..|:.||
Human   290 ILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRFLNATC 354

  Fly   246 ------NNTIPVPG----------DNILSNTTT---FLDYTGLNATTLRDNLGSHYGRDYTSNGK 291
                  ||...:.|          :|:.|:..|   .::.:|:.:..|.|.........|..:..
Human   355 DEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSVGLADGTPIDMDHPYVFSDM 419

  Fly   292 QVDFSTTFGVLFSGVTGIMAGANMSGELKNPSKSIPYGTLSAVAFTFVSYIILSFLMSCTTPYFT 356
            ...|:...|:.|..|||||||:|.||:|::..||||.||:.|:|.|...||....|.........
Human   420 TSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVV 484

  Fly   357 MQNNYLFLMPVNL------WP-PFT-AIGILTATFSTSLSNLIGSSRILEALSKD------QVFG 407
            :::.:...:..||      || |:. .||...:|....|.:|.|:.|:|:|:|:|      ||||
Human   485 LRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFG 549

  Fly   408 SLLNFVIHGTWKGNPIAAVAVSWCLVECILLIGSFNIIAQINSVLFMLSYLATNLACLGIELTGA 472
                   ||...|.|..|:.::.|:.|..:||.|.:.:|.|.|:.|::.|:..||||....|...
Human   550 -------HGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRT 607

  Fly   473 PNFRPLFKFFTWHTCLVGLLGTLIMMFVINFIYASSCIILCLILVIALHLFSPATQAAQWGSISQ 537
            ||:||.|:::.|....:|:...|.:||:.::.||   ::..||..:............:||...:
Human   608 PNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYA---LVAMLIAGLIYKYIEYRGAEKEWGDGIR 669

  Fly   538 ALMFHQVRKYLLMLDPRKDHVKFWRPQILLLVS--------SPRSCCPLVDFVNDLKK-SGLYII 593
            .|.....|..||.|:....|.|.||||:|:||.        .|:    |:...:.||. .||.|:
Human   670 GLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQ----LLSLTSQLKAGKGLTIV 730

  Fly   594 GHVKLGDFKGIED------AEDNQQWWSFLDHMRVKAFTEVTLSRSIREGVQHLIRLSGIGAMKP 652
            |.|..|.|  :|:      ||::.:  ..::..:||.|.:|.:|.::|:||.|||:..|:|.::.
Human   731 GSVLEGTF--LENHPQAQRAEESIR--RLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQH 791

  Fly   653 NTIILGFYDSEAPRDFFQNGSSPYKTDDFNNGEIQNFPIRRDGDPKQFQIQEYVQILCDTLRMKK 717
            ||:::|:     ||::                       |:..|.:.:  :.:::::.:|.....
Human   792 NTVLVGW-----PRNW-----------------------RQKEDHQTW--RNFIELVRETTAGHL 826

  Fly   718 NLCLCRNFQRLDKNFISMSKHVKYIDVWPINIFNPTSGDPFDMVSLFMMQLAVIMLAKWKHLRVR 782
            .|.:.:|......|....|:  ..||||.|         ..|...|.::...:.....|:..::|
Human   827 ALLVTKNVSMFPGNPERFSE--GSIDVWWI---------VHDGGMLMLLPFLLRHHKVWRKCKMR 880

  Fly   783 IFLCEANDERTVGTFDTQTPQMEIFSKMKLEQSLKELRITA--DIVEIQE-------WSRDTDFS 838
            ||        ||...|..:.||    |..|...|..|||||  ::||:.|       :.:.....
Human   881 IF--------TVAQMDDNSIQM----KKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVME 933

  Fly   839 RHARTLKQF-----------------------------TAQADNVVLE---DDDEVGE------- 864
            :.::.|||.                             |....||..|   |.:|..|
Human   934 QRSQILKQMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIH 998

  Fly   865 ----------------------------------------------------------------E 865
                                                                            |
Human   999 DQSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWE 1063

  Fly   866 TLNRSLLYMQ----RANQIIRERSDQTALSFIYLAAPPKLSAPDFAQRSASYMELLTELTADLPP 926
            .||:|.:...    |.|::|.::|....|..:.:..||:....|     .:|||.|..||..|..
Human  1064 NLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGD-----ENYMEFLEVLTEHLDR 1123

  Fly   927 TILVHG----VSTVTS 938
            .:||.|    |.|:.|
Human  1124 VMLVRGGGREVITIYS 1139

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10413	NP_001286048.1	2a30	22..932	CDD:273347	275/1151 (24%)
CG10413	NP_001286048.1	SLC12	577..932	CDD:281515	96/477 (20%)
SLC12A5	NP_001128243.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..63		4/16 (25%)
		2a30	44..1139	CDD:273347	283/1184 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	92..116		6/26 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	942..1052		7/109 (6%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158238
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840