Protein Alignment CG10413 and Slc12a5

DIOPT Version :9

• Sequence 1: NP_001286048.1
• Gene: CG10413 / 35111
• FlyBaseID: FBgn0032689
• Length: 941
• Species: Drosophila melanogaster
• Sequence 2: NP_001342409.1
• Gene: Slc12a5 / 57138
• MGIID: 1862037
• Length: 1138
• Species: Mus musculus
• Alignment Length: 1186
• Identity: 291/1186 - (24%)
• Similarity: 465/1186 - (39%)
• Gaps: 347/1186 - (29%)

  Fly     7 QETAPIANSR--------SGRTGSVFRS-------FGSLFGGSQN-----SGDRPHTPQDGDGYV 51
            :|::|..||.        .||..::|..       ..||..|..|     .|.|.|...:.:
Mouse    46 KESSPFINSTDTEKGREYDGRNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENN--- 107

  Fly    52 EFGMQDPDRSGRTLGTFAGVFSPVALSMFSALVFIRVGYIVGNAGLYVTLLQFLIAYGILLFTVA 116
            |.|.:.|.::.| :|||.||:.|...::|..::|:|:.::||.||:..:.....|.....:.|..
Mouse   108 EGGKKKPVQAPR-MGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAI 171

  Fly   117 SVCAISTNGAIEGGGVYFMISRTLGLEFGGSIGTLFFFANVVGSAMAISGCTEGIMDNFGP---- 177
            |:.||:|||.:..||.|:||||:||.||||::|..|:.......||.|.|..|.::....|
Mouse   172 SMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAI 236

  Fly   178 -RGHFVSGDSHLPDGDWWRFLTSSMINTLQ-----LLVCL-----VGAALFAKTSVIILATVTVC 231
             :....||::            ::|:|.::     :|.|:     ||.....|.:::.|..|.:.
Mouse   237 FKAEDASGEA------------AAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILS 289

  Fly   232 LFATY------------FSFLFVGATNNTIPVPGDNILS--------NTTT-----FLDYTGLNA 271
            :.|.|            |....:|  |.|:...|.::.:        ..||     |.....|||
Mouse   290 ILAIYAGVIKSAFDPPNFPICLLG--NRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRLLNA 352

  Fly   272 T----------------------TLRDNLGSHY--------GRDYTS----NGKQVD-------- 294
            |                      .:::||.|.|        .|...|    :|..||
Mouse   353 TCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERRGMPSVGLADGTPVDMDHPYVFS 417

  Fly   295 -----FSTTFGVLFSGVTGIMAGANMSGELKNPSKSIPYGTLSAVAFTFVSYIILSFLMSCTTPY 354
                 |:...|:.|..|||||||:|.||:|::..||||.||:.|:|.|...||....|.......
Mouse   418 DMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEG 482

  Fly   355 FTMQNNYLFLMPVNL------WP-PFT-AIGILTATFSTSLSNLIGSSRILEALSKD------QV 405
            ..:::.:...:..||      || |:. .||...:|....|.:|.|:.|:|:|:|:|      ||
Mouse   483 VVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQV 547

  Fly   406 FGSLLNFVIHGTWKGNPIAAVAVSWCLVECILLIGSFNIIAQINSVLFMLSYLATNLACLGIELT 470
            ||       ||...|.|..|:.::.|:.|..:||.|.:.:|.|.|:.|::.|:..||||....|.
Mouse   548 FG-------HGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLL 605

  Fly   471 GAPNFRPLFKFFTWHTCLVGLLGTLIMMFVINFIYASSCIILCLILVIALHLFSPATQAAQWGSI 535
            ..||:||.|:::.|....:|:...|.:||:.::.||   ::..||..:............:||..
Mouse   606 RTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYA---LVAMLIAGLIYKYIEYRGAEKEWGDG 667

  Fly   536 SQALMFHQVRKYLLMLDPRKDHVKFWRPQILLLVS--------SPRSCCPLVDFVNDLKK-SGLY 591
            .:.|.....|..||.|:....|.|.||||:|:||.        .|:    |:...:.||. .||.
Mouse   668 IRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQ----LLSLTSQLKAGKGLT 728

  Fly   592 IIGHVKLGDF----KGIEDAEDNQQWWSFLDHMRVKAFTEVTLSRSIREGVQHLIRLSGIGAMKP 652
            |:|.|..|.|    ...:.||::.:  ..::..:||.|.:|.:|.::|:||.|||:..|:|.::.
Mouse   729 IVGSVLEGTFLDNHPQAQRAEESIR--RLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQH 791

  Fly   653 NTIILGFYDSEAPRDFFQNGSSPYKTDDFNNGEIQNFPIRRDGDPKQFQIQEYVQILCDTLRMKK 717
            ||:::|:     ||::                       |:..|.:.:  :.:::::.:|.....
Mouse   792 NTVLVGW-----PRNW-----------------------RQKEDHQTW--RNFIELVRETTAGHL 826

  Fly   718 NLCLCRNFQRLDKNFISMSKHVKYIDVWPINIFNPTSGDPFDMVSLFMMQLAVIMLAKWKHLRVR 782
            .|.:.:|......|....|:  ..||||.|         ..|...|.::...:.....|:..::|
Mouse   827 ALLVTKNVSMFPGNPERFSE--GSIDVWWI---------VHDGGMLMLLPFLLRHHKVWRKCKMR 880

  Fly   783 IFLCEANDERTVGTFDTQTPQMEIFSKMKLEQSLKELRITA--DIVEIQE-------WSRDTDFS 838
            ||        ||...|..:.||    |..|...|..|||||  ::||:.|       :.:.....
Mouse   881 IF--------TVAQMDDNSIQM----KKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVME 933

  Fly   839 RHARTLKQF---------------------------------------TAQADN--------VVL 856
            :.::.|||.                                       || .||        .::
Mouse   934 QRSQILKQMHLTKNEREREIQSITDESRGSIRRKNPANPRLRLNVPEETA-CDNEEKPEEEVQLI 997

  Fly   857 ED---------------------------------DDEVGE-----------------------E 865
            .|                                 |..|.|                       |
Mouse   998 HDQSAPSCPSSSPSPGEEPEGERETDPEVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWE 1062

  Fly   866 TLNRSLLYMQ----RANQIIRERSDQTALSFIYLAAPPKLSAPDFAQRSASYMELLTELTADLPP 926
            .||:|.:...    |.|::|..:|....|..:.:..||:....|     .:|||.|..||..|..
Mouse  1063 NLNQSNVRRMHTAVRLNEVIVNKSRDAKLVLLNMPGPPRNRNGD-----ENYMEFLEVLTEQLDR 1122

  Fly   927 TILVHG----VSTVTS 938
            .:||.|    |.|:.|
Mouse  1123 VMLVRGGGREVITIYS 1138

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10413	NP_001286048.1	2a30	22..932	CDD:273347	281/1151 (24%)
		SLC12	577..932	CDD:281515	96/475 (20%)
Slc12a5	NP_001342409.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..62		4/15 (27%)
		2a30	44..1138	CDD:273347	290/1184 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	96..116		6/22 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	943..1051		8/108 (7%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848623
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840