DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10413 and SLC12A9

DIOPT Version :9

Sequence 1:	NP_001286048.1	Gene:	CG10413 / 35111	FlyBaseID:	FBgn0032689	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_001350422.1	Gene:	SLC12A9 / 56996	HGNCID:	17435	Length:	914	Species:	Homo sapiens

Alignment Length:	936	Identity:	394/936 - (42%)
Similarity:	531/936 - (56%)	Gaps:	109/936 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 SGRTLGTFAGVFSPVALSMFSALVFIRVGYIVGNAGLYVTLLQFLIAYGILLFTVASVCAISTNG 125
            |.|.|.||.||..|..|||||.:||:|:|::||:|||...|...|:||.||..||.|||||:|||
Human    33 SARKLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVCAIATNG 97

  Fly   126 AIEGGGVYFMISRTLGLEFGGSIGTLFFFANVVGSAMAISGCTEGIMDNFGPRGHFVSGDSHLPD 190
            |::|||.|||||||||.|.|||||.:|:.|||.|.|:::.|..|.::|.||......||...||.
Human    98 AVQGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESVLDVFGADATGPSGLRVLPQ 162

  Fly   191 GDWWRFLTSSMINTLQLLVCLVGAALFAKTSVIILATVTVCLFATYFSFLFVGATN-NTIPVPGD 254
            |..|..|..|::..|...||.:||.|:|:.|.:....|:..|.:...||:.||..: ...|.||.
Human   163 GYGWNLLYGSLLLGLVGGVCTLGAGLYARASFLTFLLVSGSLASVLISFVAVGPRDIRLTPRPGP 227

  Fly   255 NILSNTTTFLDYTGLNATTLRDNLGSHYGRDYTSNGKQVDFSTTFGVLFSGVTGIMAGANMSGEL 319
            |..|....|..:||.|::||:||||:.|..|||: |..::|::.|.|||:|.|||||||||||||
Human   228 NGSSLPPRFGHFTGFNSSTLKDNLGAGYAEDYTT-GAVMNFASVFAVLFNGCTGIMAGANMSGEL 291

  Fly   320 KNPSKSIPYGTLSAVAFTFVSYIILSFLMSCTTPYFTMQNNYLFLMPVNLWPPFTAIGILTATFS 384
            |:||::||.||:.|||:||..|::|.||.|.|.....:|.:|.|...::||||...|||.....|
Human   292 KDPSRAIPLGTIVAVAYTFFVYVLLFFLSSFTCDRTLLQEDYGFFRAISLWPPLVLIGIYATALS 356

  Fly   385 TSLSNLIGSSRILEALSKDQVFGSLL---NFVIHGTWKGNPIAAVAVSWCLVECILLIGSFNIIA 446
            .|:|:|||:||||.||::|.:||.:|   ..|..|   |||.|||..||.||:.:||.|..|.:|
Human   357 ASMSSLIGASRILHALARDDLFGVILAPAKVVSRG---GNPWAAVLYSWGLVQLVLLAGKLNTLA 418

  Fly   447 QINSVLFMLSYLATNLACLGIELTGAPNFRPLFKFFTWHTCLVGLLGTLIMMFVINFIYASSCII 511
            .:.:|.::::|.|.:|:||.:|...||||||.|..|:|||||:|:...|:|||:|:...|...::
Human   419 AVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGAAGGSLL 483

  Fly   512 LCLILVIALHLFSPATQAAQWGSISQALMFHQVRKYLLMLDPRKDHVKFWRPQILLLVSSPRSCC 576
            |..:|..   |.:.....:.||.:||||:|||||||||.||.|||||||||||:||||.:||...
Human   484 LMGLLAA---LLTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLLLLVGNPRGAL 545

  Fly   577 PLVDFVNDLKKSGLYIIGHVKLGDFKGIEDAEDNQQ---WWSFLDHMRVKAFTEVTLSRSIREGV 638
            ||:...|.|||.|||::|||.|||...:.......|   |.|.:|..:||||.::|||.|:|:|.
Human   546 PLLRLANQLKKGGLYVLGHVTLGDLDSLPSDPVQPQYGAWLSLVDRAQVKAFVDLTLSPSVRQGA 610

  Fly   639 QHLIRLSGIGAMKPNTIILGFYDSEAPRDFF-------------QNGSSPYKTDDFNNGEIQNFP 690
            |||:|:||:|.|||||::|||||...|:|.|             :.||||..:..|.       |
Human   611 QHLLRISGLGGMKPNTLVLGFYDDAPPQDHFLTDPAFSEPADSTREGSSPALSTLFP-------P 668

  Fly   691 IRRDGDPKQFQIQEYVQILCDTLRMKKNLCLCRNFQRLDKNFISM----SKHVKYIDVWPINIFN 751
            .|..|.|:....|:||..:.|.|:|.||:.|.|....|....:|.    :..:.::||||:|:..
Human   669 PRAPGSPRALNPQDYVATVADALKMNKNVVLARASGALPPERLSRGSGGTSQLHHVDVWPLNLLR 733

  Fly   752 PTSGDPF-DMVSLFMMQLAVI--MLAKWKHLRVRIFLCEANDERTVGTFDTQTPQMEIFSKMKLE 813
            |..|..: |:..||::|:|.|  |:..|...|:|||||....|....            ::.:|.
Human   734 PRGGPGYVDVCGLFLLQMATILGMVPAWHSARLRIFLCLGPREAPGA------------AEGRLR 786

  Fly   814 QSLKELRITADIVEI----------QEWSRDTDFSRHARTLKQFTAQADNVVLEDDDEVGEETLN 868
            ..|.:|||.|::.|:          .|...:.||....|               .|.|.  |.|.
Human   787 ALLSQLRIRAEVQEVVWGEGAGAGEPEAEEEGDFVNSGR---------------GDAEA--EALA 834

  Fly   869 RSLLYMQRANQIIRERSDQ------------------TALSFIYLAAPPKLSAPDFAQRSASYME 915
            ||      ||.::|.:..:                  |||:|:||..||...|     |...|:.
Human   835 RS------ANALVRAQQGRGTGGGPGGPEGGDAEGPITALTFLYLPRPPADPA-----RYPRYLA 888

  Fly   916 LLTELTADLPPTILVHGVSTVTSTTL 941
            ||..||.||.||:|||||:.||.|.|
Human   889 LLETLTRDLGPTLLVHGVTPVTCTDL 914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10413	NP_001286048.1	2a30	22..932	CDD:273347	387/925 (42%)
CG10413	NP_001286048.1	SLC12	577..932	CDD:281515	133/405 (33%)
SLC12A9	NP_001350422.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	844..863		0/18 (0%)
		SLC12	36..905	CDD:332077	385/922 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	642..678		9/42 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158235
Domainoid	1	1.000	451	1.000	Domainoid score	I512
eggNOG	1	0.900	-	-		E2759_KOG1288
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5429
Inparanoid	1	1.050	660	1.000	Inparanoid score	I771
Isobase	1	0.950	-	0	Normalized mean entropy	S1765
OMA	1	1.010	-	-		QHG48944
OrthoDB	1	1.010	-	-		D310826at33208
OrthoFinder	1	1.000	-	-		FOG0004225
OrthoInspector	1	1.000	-	-		oto90222
orthoMCL	1	0.900	-	-		OOG6_104998
Panther	1	1.100	-	-	LDO	PTHR11827
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1968
SonicParanoid	1	1.000	-	-		X2970
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750