Protein Alignment CG10413 and slc12a7b

DIOPT Version :10

• Sequence 1: NP_609887.1
• Gene: CG10413 / 35111
• FlyBaseID: FBgn0032689
• Length: 941
• Species: Drosophila melanogaster
• Sequence 2: XP_005162967.1
• Gene: slc12a7b / 567667
• ZFINID: ZDB-GENE-030829-61
• Length: 1138
• Species: Danio rerio
• Alignment Length: 1173
• Identity: 271/1173 - (23%)
• Similarity: 454/1173 - (38%)
• Gaps: 335/1173 - (28%)

  Fly     7 QETAPIANSRSGRTGSVFRSFG-SLFGGSQNS-------------------GDRPHTPQDGD-GY 50
            :|::|..|:.....|:::.... :||....:|                   |.|.|...|.| |.
Zfish    60 RESSPFINNTDDDKGNLYDGKNMALFEEEMDSNPMVSSLLNKLANYTNLTQGVREHEEADEDEGA 124

  Fly    51 VEFGMQDPDRSGRTLGTFAGVFSPVALSMFSALVFIRVGYIVGNAGLYVTLLQFLIAYGILLFTV 115
            .:..::.|.     :|||.||:.|...::...::|:|:.:|||.||:....:...:.....:.|.
Zfish   125 KKQTVKSPQ-----MGTFIGVYLPCLQNILGVILFLRMTWIVGTAGILEAFIIVSMCCSCTMLTA 184

  Fly   116 ASVCAISTNGAIEGGGVYFMISRTLGLEFGGSIGTLFFFANVVGSAMAISGCTEGIMDNFGPRGH 180
            .|:.||:|||.:..||.|:||||:||.||||::|..|:.......||.|.|..|.::....|...
Zfish   185 ISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLTYIVPSAA 249

  Fly   181 FVSGDSHLPDGDWWRFLTSSMIN----------TLQLLVCLVGAALFAKTSVIILATVTVCLFAT 235
            ....:....:.:       :::|          ||..||..||.....|.:::.||.|.:.:.|.
Zfish   250 IFKAEDKADEAE-------ALLNNMRVYGTCCLTLMALVVFVGVKYVNKLALVFLACVVLSILAI 307

  Fly   236 Y------------FSFLFVGATNNTIPVPG----------DNI---------------------- 256
            |            |....:|  |.|:....          ||:
Zfish   308 YAGVIKTIFEPPVFPVCVLG--NRTLQNHDFDKCMKTEIIDNVTVTTKLWSLFCSGPELNASCNE 370

  Fly   257 ---LSNTTTFLDYTGLNATTLRDNLGSHYG-------RD----------------YTSNGKQVDF 295
               |::.|......||.:..:.:|:...||       :|                |..|.....|
Zfish   371 YFTLNSVTEIQGIPGLTSGVISENMWGKYGPAGMLVEKDIPSVSASDSSQDKYMPYVVNDITAFF 435

  Fly   296 STTFGVLFSGVTGIMAGANMSGELKNPSKSIPYGTLSAVAFTFVSYIILSFLMSCTTPYFTMQNN 360
            :...|:.|..|||||||:|.||:|::..:|||.||:.|:|.|.:.|:....|.........:::.
Zfish   436 TLLVGIYFPSVTGIMAGSNRSGDLRDAQRSIPIGTILAIATTTIIYLSCVVLFGACIEGVVLRDK 500

  Fly   361 YLFLMPVNL------WP-PFT-AIGILTATFSTSLSNLIGSSRILEALSKD------QVFGSLLN 411
            :...:..||      || |:. .||...:.....|.:|.|:.|:|:|:::|      :|||
Zfish   501 FGDSVKGNLVIGTLSWPSPWVIVIGSFFSCCGAGLQSLTGAPRLLQAIARDGIVPFLEVFG---- 561

  Fly   412 FVIHGTWKGNPIAAVAVSWCLVECILLIGSFNIIAQINSVLFMLSYLATNLACLGIELTGAPNFR 476
               ||...|.|..|:.::..:.|..:||.|.:.:|.|.|:.|::.||..||||....|...||:|
Zfish   562 ---HGKANGEPTWALLLTALICESGILIASLDAVAPILSMFFLMCYLFVNLACALQTLLRTPNWR 623

  Fly   477 PLFKFFTWHTCLVGLLGTLIMMFVINFIYASSCIILCLILVIALHLFSPATQA-AQWGSISQALM 540
            |.||::.|....:|:...|.:||:.::.||    ::.:::...::.:.....| .:||...:.|.
Zfish   624 PRFKYYHWALSFLGMSLCLALMFISSWYYA----LVAMLIAGCIYKYIEYRGAEKEWGDGIRGLS 684

  Fly   541 FHQVRKYLLMLDPRKDHVKFWRPQILLLVSSPRSCC----PLVDFVNDLKK-SGLYIIGHVKLGD 600
            .:..|..|:.|:....|.|.||||:|:|::.....|    .|:.|...||. .||.|:|.|..|.
Zfish   685 LNAARYALIRLEEAPPHTKNWRPQMLVLLNLDSELCVKHPRLLSFTTQLKAGKGLTIVGSVLEGT 749

  Fly   601 FKGIED----AEDNQQWWSFLDHMRVKAFTEVTLSRSIREGVQHLIRLSGIGAMKPNTIILGFYD 661
            :...|:    ||.|.:  |.:...:.|.|..|.:|.::|:|:.||::.:|:|.||.|::::.:
Zfish   750 YLSRENQAKRAEQNIK--SAMAAEKTKGFCHVVVSSNLRDGISHLVQSAGLGGMKHNSVLMAW-- 810

  Fly   662 SEAPRDFFQNGSSPYKTDDFNNGEIQNFPIRRDGDPKQFQIQEYVQILCDT------LRMKKNLC 720
               |.::                       |:..||..:  :.:::.:.:|      |.:.||:.
Zfish   811 ---PSNW-----------------------RQSSDPHTW--RSFIETVRETTAAHLALLVAKNVD 847

  Fly   721 LCRNFQRLDKNFISMSKHVKYIDVWPINIFNPTSGDPFDMVSLFMMQLAVIMLAKWKHLRVRIFL 785
            ...:.:||.:.         .||||.|    ...|....::...:.|..|     ||..::|||
Zfish   848 SFPHQERLTEG---------TIDVWWI----VHDGGMLMLLPFLLRQHKV-----WKKCKMRIF- 893

  Fly   786 CEANDERTVGTFDTQTPQMEIFSKMKLEQSLKELRITADIVEIQEWSRDTDFS-----------R 839
                   ||...|..:.||    |..|:..|..||:.|: ||:.| ..|:|.|           :
Zfish   894 -------TVAQMDDNSIQM----KKDLQMFLYHLRLNAE-VEVVE-MHDSDISAFTYEKTLVMEQ 945

  Fly   840 HARTLKQF---------------------------------TAQADNVVLEDDDEVG-------- 863
            .::.|||.                                 :.|..|...|..||..
Zfish   946 RSQMLKQMQLSRTEREREIQSITDESRSSIRRKNQSEAHSSSLQNQNTAHEQQDEAQLIHDRNTA 1010

  Fly   864 ----------------EETLNRSLLYMQRA----------------------------------- 877
                            ..|..:..|:.:|:
Zfish  1011 SHTAMNDKADATPERVHMTWTKEKLFSERSRRTEANASMAVRDLFNMKPEWESLNQSNVRCMHTA 1075

  Fly   878 ---NQIIRERSDQTALSFIYLAAPPKLSAPDFAQRSASYMELLTELTADLPPTILVHG----VST 935
               |::|..:|....|..:.:..|||....|     .:|||.:..:...|...:||.|    |.|
Zfish  1076 VKLNEVIVNKSQGAHLVLLNMPGPPKNRGGD-----ENYMEFMEVMMEGLNRVLLVRGGGREVIT 1135

  Fly   936 VTS 938
            :.|
Zfish  1136 IYS 1138

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10413	NP_609887.1	AA_permease_2	22..932	CDD:459263	263/1146 (23%)
slc12a7b	XP_005162967.1	2a30	58..1138	CDD:273347	270/1171 (23%)