DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10413 and slc12a4

DIOPT Version :9

Sequence 1:	NP_001286048.1	Gene:	CG10413 / 35111	FlyBaseID:	FBgn0032689	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	XP_691291.2	Gene:	slc12a4 / 562826	ZFINID:	ZDB-GENE-090218-27	Length:	1095	Species:	Danio rerio

Alignment Length:	1080	Identity:	282/1080 - (26%)
Similarity:	443/1080 - (41%)	Gaps:	293/1080 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 QDPDRSGR------TLGTFAGVFSPVALSMFSALVFIRVGYIVGNAGLYVTLLQFLIAYGILLFT 114
            :..|.|.|      .:||..||:.|...::|..::|:|:.:|||.||:..:.|..|:.....:.|
Zfish   112 ESADASRRQAPKSPNMGTLMGVYLPCLQNIFGVILFLRLTWIVGTAGVVQSFLIVLMCCSCTMLT 176

  Fly   115 VASVCAISTNGAIEGGGVYFMISRTLGLEFGGSIGTLFFFANVVGSAMAISGCTEGIMDNFGPRG 179
            ..|:.||:|||.:..||.||||||:||.||||::|..|:......:||.|.|..|..:....|:.
Zfish   177 AISMSAIATNGVVPAGGAYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLKYLIPQA 241

  Fly   180 H-FVSGDSHLPDGDWWRFLTSSMINTLQL--LVCL--------VGAALFAKTSVIILATVTVCLF 233
            . |...|.|..:|        :|:|.:::  .:||        ||.....|.:.:.||.|.:.:.
Zfish   242 AIFHPADIHAGNG--------AMLNNMRVYGTICLSLMAVVVFVGVKYVNKLASLFLACVIISIV 298

  Fly   234 ATY------------FSFLFVG-----------------ATNNTIP-------VPGDNILS---- 258
            :.|            |....:|                 ..|.|:|       ...|||.|
Zfish   299 SIYAGAVKSIFHPPEFPICMLGNRTLVRDLFDVCGKTVVVGNETVPSKLWKNFCTSDNISSAHCD 363

  Fly   259 ------NTTTFLDYTGLNATTLRDNLGSHYGRDYTSNGK-----------------------QVD 294
                  |.|......||.:..:::|:   :| ||...|:                       ..|
Zfish   364 EYFFHNNVTEIKGIPGLASGIIKENM---WG-DYMEKGQILEKAKLPSVDVHGSMETFGFYVSAD 424

  Fly   295 FSTTF----GVLFSGVTGIMAGANMSGELKNPSKSIPYGTLSAVAFTFVSYIILSFLMSCTTPYF 355
            .:|:|    |:.|...||||||:|.||:|::..||||.||:.|:..|.:.|.....|........
Zfish   425 IATSFTLLVGIFFPSATGIMAGSNRSGDLRDAQKSIPIGTILAITTTSLVYFSSVVLFGACIEGV 489

  Fly   356 TMQNNYLFLMPVNL------WP-PFT-AIGILTATFSTSLSNLIGSSRILEALSKD------QVF 406
            .:::.:...:..||      || |:. .||...:|....|.:|.|:.|:|:|::||      :||
Zfish   490 VLRDKFGDAVSKNLVVGTLSWPSPWVIVIGSFFSTVGAGLQSLTGAPRLLQAIAKDNIIPFLRVF 554

  Fly   407 GSLLNFVIHGTWKGNPIAAVAVSWCLVECILLIGSFNIIAQINSVLFMLSYLATNLACLGIELTG 471
            |       ||...|.|..|:.::..:.|..:||.|.:::|.|.|:.|::.||..||||....|..
Zfish   555 G-------HGKANGEPTWALLLTGLIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLR 612

  Fly   472 APNFRPLFKFFTWHTCLVGLLGTLIMMFVINFIYASSCIILCLILVIALHLFSPATQA-AQWGSI 535
            .||:||.|:::.|....:|:...|.:||:.::.||    |:.:.:...::.:.....| .:||..
Zfish   613 TPNWRPRFRYYHWALSFLGMSMCLALMFISSWYYA----IVAMGIAGMIYKYIEYQGAEKEWGDG 673

  Fly   536 SQALMFHQVRKYLLMLDPRKDHVKFWRPQILLL--------VSSPRSCCPLVDFVNDLKK-SGLY 591
            .:.|.....|..||.|:....|.|.||||:|:|        |..||    |:.|.:.||. .||.
Zfish   674 IRGLSLSAARYSLLRLEAGPPHTKNWRPQLLVLLKLDEDLHVKYPR----LLTFASQLKAGKGLT 734

  Fly   592 IIGHVKLGDFKGI--EDAEDNQQWWSFLDHMRVKAFTEVTLSRSIREGVQHLIRLSGIGAMKPNT 654
            |:|.|..|:|...  |.....|...:.::..|||.|.:|.::..:|||:.|||:..|:|.||.||
Zfish   735 IVGSVIQGNFLECYGETQASEQAIKNMMEIERVKGFCQVVVASKVREGIAHLIQSCGLGGMKHNT 799

  Fly   655 IILGFYDSEAPRDFFQNGSSPYKTDDFNNGEIQNFPIRRDGDPKQFQIQEYVQ-ILCDT-----L 713
            :::|:               ||..             |:..||:.:  :.::. :.|.|     |
Zfish   800 VVMGW---------------PYGW-------------RQSEDPRAW--KTFINTVRCTTAAHLAL 834

  Fly   714 RMKKNLCLC-RNFQRLDKNFISMSKHVKYIDVWPINIFNPTSGDPFDMVSLFMMQLAVIMLAKWK 777
            .:.||:... .|.:|....         |||||.|    ...|....::...:.|..|     |:
Zfish   835 MVPKNVSFYPSNHERFTDG---------YIDVWWI----VHDGGMLMLLPFLLKQHKV-----WR 881

  Fly   778 HLRVRIFLCEANDERTVGTFDTQTPQMEIFSKMKLEQSLKELRITADIVEIQEWSRDTDFS---- 838
            ..::|||        ||...|..:.||    |..|...|.:||:.|: ||:.| ..|:|.|
Zfish   882 KCKMRIF--------TVAQMDDNSIQM----KKDLATFLYQLRLEAE-VEVVE-MHDSDISAYTY 932

  Fly   839 -------RHARTLKQF---TAQADNVV--------------LEDDDEVGEETLN----------- 868
                   :.::.|||.   :|:.|...              |..|:|  |||:.
Zfish   933 ERTLMMEQRSQMLKQMRLSSAERDREAQLVKDRHSLIRMGSLYSDEE--EETIEILPEKNQMTWT 995

  Fly   869 ------------------RSLLYMQ-------------RANQIIRERSDQTALSFIYLAAPPKLS 902
                              |.|:.::             :.|::|..:|....|..:.:..||:..
Zfish   996 SEKIEAERRNRNNAPENFRELISIKPDQSNVRRMHTAVKLNEVIVNKSHDARLVLLNMPGPPRNQ 1060

  Fly   903 APDFAQRSASYMELLTELTADLPPTILVHG----VSTVTS 938
            ..|     .:|||.|..||..|...:||.|    |.|:.|
Zfish  1061 EGD-----ENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1095

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10413	NP_001286048.1	2a30	22..932	CDD:273347	278/1068 (26%)
CG10413	NP_001286048.1	SLC12	577..932	CDD:281515	102/434 (24%)
slc12a4	XP_691291.2	2a30	50..1095	CDD:273347	281/1078 (26%)
slc12a4	XP_691291.2	SLC12	718..1095	CDD:281515	107/449 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594131
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840