DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10413 and slc12a10.3

DIOPT Version :9

Sequence 1:	NP_001286048.1	Gene:	CG10413 / 35111	FlyBaseID:	FBgn0032689	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	XP_021333240.1	Gene:	slc12a10.3 / 562763	ZFINID:	ZDB-GENE-060503-518	Length:	1001	Species:	Danio rerio

Alignment Length:	996	Identity:	248/996 - (24%)
Similarity:	408/996 - (40%)	Gaps:	189/996 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SQNSGDRPHTPQDGDG-----YVEFGMQDPDRSGRTLGTFAGVFSPVALSMFSALVFIRVGYIVG 93
            |.:..|.|..|:| ||     .|.||.            ..||.....|:::..::|:|:.:|..
Zfish    87 SPDPDDLPPPPED-DGRPKVKLVRFGW------------VLGVMIRCMLNIWGVIMFLRLPWITS 138

  Fly    94 NAGLYVTLLQFLIAYGILLFTVASVCAISTNGAIEGGGVYFMISRTLGLEFGGSIGTLFFFANVV 158
            .||:.:|.:...::..|...|..||.||||||.:..||.||:|||:||.|.|..||.||.|||.:
Zfish   139 QAGIILTYVIIFMSVTITTITATSVSAISTNGKVYSGGTYFLISRSLGPELGAPIGLLFSFANAL 203

  Fly   159 GSAMAISGCTEGIMDNFGPRGHFVSGDSHLPDGDWWRFLTSSMINTLQ----LLVCLVGAALFAK 219
            ..::...|..|.:.|........:..|.:          ...:|.|:.    ||:...|.|..||
Zfish   204 ACSLNTVGFAETVRDVLKENNAQMVDDVN----------DVRIIGTITVCILLLITFAGMAWEAK 258

  Fly   220 TSVIILATVTVCLFATYFSFLFVGATNNTI--PVPGDNILSNTTTFLDYTGLNATTLRDNLGSHY 282
            ..::....:.:.| |.|    |||    |:  |.|....:.       :.|..|....|||...:
Zfish   259 AQILFFIALLISL-ANY----FVG----TLLPPTPEKQAVG-------FFGYRAEIFVDNLLPSF 307

  Fly   283 GRDYTSNGKQVDFSTTFGVLFSGVTGIMAGANMSGELKNPSKSIPYGTLSAVAFTFVSYIILSFL 347
                  .||...|...|.:.|...|||::|.|:.|:||:||..||.|||.|:.:|.|||::::..
Zfish   308 ------RGKDGSFFRMFSIFFPSATGILSGVNICGDLKDPSGGIPKGTLLAIFWTTVSYLLIAIT 366

  Fly   348 MSCT---------------------------------------TPYFTMQNNYLFLMPVNLWPPF 373
            ::.:                                       |..|.:.|.:..|...:.....
Zfish   367 VAASVVRDASGNLNDSLALDSSIQCSGLGCKLGWNFDHCEQNHTCSFGLANYFQILTTASGTGHL 431

  Fly   374 TAIGILTATFSTSLSNLIGSSRILEALSKDQVFGSLLNFVIHGTWKG-NPIAAVAVSWCLVECIL 437
            ..|||..||.|::|..|:.:.:|.:.|.||.:: ..:.|...|..|. .|:....:.:.:....:
Zfish   432 ITIGIFAATLSSALGFLVSAPKIFQCLCKDNIY-PYIGFFGKGYGKNQEPLRGYLLMFFIALAFI 495

  Fly   438 LIGSFNIIAQINSVLFMLSYLATNLACLGIELTGAPNFRPLFKFFTWHTCLVGLLGTLIMMFVIN 502
            |||..|.||.:.|..|:.||...|.:|....:|.:|.:||.:.:|:..|.|.....:.|:||:
Zfish   496 LIGDLNTIAPLISNFFLCSYGLINFSCFHATITKSPGWRPHYHYFSPWTSLFAAFLSFILMFL-- 558

  Fly   503 FIYASSCIILCLILVIALHLFSPATQAAQWGSISQALMFHQVRKYLLMLDPRKDHVKFWRPQILL 567
            |.:.::.:...::|.: |...:.......||:..||..::....:.:.|...:||||.:|||.|:
Zfish   559 FTWWAALVTFAIVLSL-LGYVTYKKPKINWGTSYQASFYNMALSFSMSLTGVEDHVKNFRPQCLV 622

  Fly   568 LVSSPRSCCPLVDFVNDLKKS-GLYIIGHVKLGDFKGIEDAEDNQQWWSFLDHMRVKAFTEVTLS 631
            |...|.....|||||....|: .|.|.|::.:.:.|.............:|:..:|:||.....:
Zfish   623 LTGPPNVRPALVDFVGTFTKNISLMICGNIFMVEEKSRFPQHSTDMLVDWLNQRKVRAFYTSFTA 687

  Fly   632 RSIREGVQHLIRLSGIGAMKPNTIILGFYDS------EAPRDFFQNGSSPYKTDDFNNG-----E 685
            .|:.||...|::.||:|.:||||::||:..:      |..:|:|...|..:   |.:.|     .
Zfish   688 DSLTEGTHSLMQASGLGKLKPNTLVLGYKTNWQECKPERLQDYFNTISDAF---DSSYGIAVLRM 749

  Fly   686 IQNFPIRRD---G-----DPKQFQIQEYVQILCDTLRMKKNLCLCRNFQRLD-------KNFISM 735
            :....||.|   |     |...|:..|..:        .:|....||....|       |.....
Zfish   750 MDGLDIREDLTSGRSSAIDNPAFEADENTK--------SENEETDRNSDISDDGSNDQVKTVFQT 806

  Fly   736 SKHVKYIDVWPINIFNPTSGDPFDMVSLFMMQLAVIMLAKWKHLRVRIFLCEANDERTVGTFDTQ 800
            .:..|.||::.|:         .|.....::...:....:||..::|:|:  ..|:.|:
Zfish   807 KQGRKTIDIYWIS---------DDGGLTLLVPYLLTRRNRWKKSKIRVFV--LGDQETM------ 854

  Fly   801 TPQMEIFSKMKLEQSLKELRI-TADIVEIQEWSRDTDFSRHARTLKQFTAQADNVVLEDDDEVGE 864
               .|....||:  .||..|: ..||:.|    .|.|....|:.|:::........|.::...|:
Zfish   855 ---QEDHKDMKM--LLKRFRLEIEDIIVI----TDVDKPPLAKNLQRYDDSVAPFRLTEEQSRGD 910

  Fly   865 -----------------ETLNRSLLYMQRANQIIRERSDQTALSFIYLAAPPKLSAPDFAQRSAS 912
                             |.:...:....|.|:||::.|:..||..:.|.. |.|:.|     |:.
Zfish   911 LQEFRRLNPWTVSDKDLEAIRPKIERTVRLNEIIKKNSNHAALVVVSLPV-PDLNCP-----SSL 969

  Fly   913 YMELLTELTADLP-PTILVHG 932
            ||..:..|:..:. |.:|:.|
Zfish   970 YMAWMEALSFGIHCPALLIRG 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10413	NP_001286048.1	2a30	22..932	CDD:273347	247/994 (25%)
CG10413	NP_001286048.1	SLC12	577..932	CDD:281515	89/400 (22%)
slc12a10.3	XP_021333240.1	SLC12	54..1000	CDD:332077	248/996 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594135
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840