Protein Alignment CG10413 and slc12a7a

DIOPT Version :10

• Sequence 1: NP_609887.1
• Gene: CG10413 / 35111
• FlyBaseID: FBgn0032689
• Length: 941
• Species: Drosophila melanogaster
• Sequence 2: XP_005171306.1
• Gene: slc12a7a / 558214
• ZFINID: ZDB-GENE-070912-696
• Length: 1117
• Species: Danio rerio
• Alignment Length: 1068
• Identity: 276/1068 - (25%)
• Similarity: 439/1068 - (41%)
• Gaps: 236/1068 - (22%)

  Fly    52 EFGMQDPDRSGRTLGTFAGVFSPVALSMFSALVFIRVGYIVGNAGLYVTLLQFLIAYGILLFTVA 116
            |.|:|....:|..:|||.|||.|...::...::|:|:.:|||.||:...|....:.....:.|..
Zfish   105 EDGIQRVTVNGPQMGTFIGVFLPCTQNILGVILFLRLTWIVGTAGILEALAVVFMCCACTMLTAI 169

  Fly   117 SVCAISTNGAIEGGGVYFMISRTLGLEFGGSIGTLFFFANVVGSAMAISGCTEGIMDNFGPRGHF 181
            |:.||:|||.:..||.|:||||.||.|.||::|..|:.......:|.|.|..|..:....|....
Zfish   170 SMSAIATNGVVPAGGSYYMISRALGPEIGGAVGLCFYLGTTFAGSMYILGTMEIFLTYIMPSAAV 234

  Fly   182 VSGDSHLPDGDWWRFLTSSMINTLQL----------LVCLVGAALFAKTSVIILATVTVCLFATY 236
            ...::  |.|         |.|.:::          ||..||.....|.|::.|:.|.:.:.|.|
Zfish   235 FEANN--PTG---------MQNNMRIYGTCCLAIMTLVVFVGVKYVNKLSLVFLSCVVLSIMAIY 288

  Fly   237 ------------FSFLFVGATNNTIPVPG--------------DNILSNTT--------TFLDYT 267
                        |:...:|  |.|:...|              |||...|.        |..:|.
Zfish   289 AGVIQSAIKPSSFTICLLG--NRTLQHFGKSGKFDKCMKTEVIDNITKPTELWYHFCNGTCDEYF 351

  Fly   268 GLNATT------------LRDNLGSHYG------------------------RDYTSNGKQVDFS 296
            .||..|            :.:||.|.||                        ..|..|.....|:
Zfish   352 NLNELTEISAVPGLLSNAITENLWSRYGEYRTTVEKENITSEAALSSEPEVLNSYVVNDMATFFT 416

  Fly   297 TTFGVLFSGVTGIMAGANMSGELKNPSKSIPYGTLSAVAFTFVSYIILSFLMSCTTPYFTMQNNY 361
            ...|:.|..|||||||:|.||:|::|.:|||.||:.|:|.|...||....|.........:::.|
Zfish   417 LLVGIYFPSVTGIMAGSNRSGDLRDPQRSIPTGTIMAIATTSFIYISCVVLFGACFEGVVLRDKY 481

  Fly   362 LFLMPVNL------WP-PFT-AIGILTATFSTSLSNLIGSSRILEALSKD------QVFGSLLNF 412
            ...:..||      || |:. .||...:.....|.:|.|:.|||:|:::|      ||||
Zfish   482 GDSVNKNLVVATLAWPSPWVIVIGSFFSCCGAGLQSLTGAPRILQAIARDGIMPFLQVFG----- 541

  Fly   413 VIHGTWKGNPIAAVAVSWCLVECILLIGSFNIIAQINSVLFMLSYLATNLACLGIELTGAPNFRP 477
              .....|.|..|:.::..:.|..:||.|.:.:|.|.|:.|::.||..||||....|...||:||
Zfish   542 --RSKSGGEPTWALLLTAAICEIGILIASLDAVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRP 604

  Fly   478 LFKFFTWHTCLVGLLGTLIMMFVINFIYASSCIIL--CLILVIALHLFSPATQAAQWGSISQALM 540
            .|||:.|....:|:..:|.:|||.::.||...|::  |:...|.   :..|.:  :||...:.|.
Zfish   605 RFKFYHWSLSFLGMSLSLSLMFVSSWYYALVVILIAGCIYKYIE---YRGAVK--EWGDGLRGLS 664

  Fly   541 FHQVRKYLLMLDPRKDHVKFWRPQILLL--------VSSPRSCCPLVDFVNDLKK-SGLYIIGHV 596
            .:..|..|:.|:..:.|.|.||||:|:|        |..||    |:.|.:.||. .||.|:..|
Zfish   665 LNAARYALIKLEEAQPHTKNWRPQLLVLMKLDTDLTVKHPR----LLSFTSQLKAGKGLTIVCSV 725

  Fly   597 KLGDF--KGIEDAEDNQQWWSFLDHMRVKAFTEVTLSRSIREGVQHLIRLSGIGAMKPNTIILGF 659
            ..|.|  :|.:.....|...:.:...:.|.|..|.:|.:.|:|..|||:.:|:|.||.|.:::.:
Zfish   726 LEGTFMVRGADAKLAEQNIKAAMAKEKTKGFCHVVVSSNQRDGFSHLIQSAGLGGMKHNAVLVAW 790

  Fly   660 YDSEAPRDFFQNGSS-----------------------------PYKTDDFNNGEIQNFPIRRDG 695
                 |.::.|..||                             |...|....|.|..:.|..||
Zfish   791 -----PANWKQAESSLSWKNFIETVRETTAAHQALLVAKNVDTFPSNQDRLAEGTIDVWWIVHDG 850

  Fly   696 DPKQFQIQEYVQILCDTLRMKK--NLCLCRNF--QRLDKNFISMSK-------HVKYIDVWPINI 749
            .        .:.:|...||..|  ..|..|.|  .::|.|.|.|.|       |:: :|. .:.:
Zfish   851 G--------LLMLLPFLLRQHKVWRKCKMRIFTVAQMDDNSIQMKKDLQMFLYHLR-LDA-KVEV 905

  Fly   750 FNPTSGDPFDMVSLFMMQLAVIMLAKWKHLRVRIFLCEANDERTVGTFDTQTPQMEIFSKMKLEQ 814
            ....:||    :|.|..:..::|..:.:.|: ::.|.:...||.:.:...:: ::.|..|...|:
Zfish   906 VEMNAGD----ISAFTYEKTLVMEQRSQMLK-QMQLSKTEREREIQSISDES-RISIRRKPCGEK 964

  Fly   815 SLKELRITADIVEIQEWSR---DTDFSRHARTLKQFTAQADNVVLEDDDE--VGE---------- 864
            .....::....|.:.|.::   |.:...||..:::.|..:|.|.:....|  :||
Zfish   965 QTHNSKLKVATVNLDEEAQLIHDKNTKSHATLVEKATPTSDRVHMTWTKEKLIGERNRLRDASMH 1029

  Fly   865 ---------------ETLNRSLLYMQRANQIIRERSDQTALSFIYLAAPPKLSAPDFAQRSASYM 914
                           :|..|.:....:.|:::.::|....|..:.:..|||....|     .:||
Zfish  1030 VRDIFNMKPEWENLDQTNVRRMHTAVKLNEVVVKKSKGAQLVLLNMPGPPKNKGGD-----ENYM 1089

  Fly   915 ELLTELTADLPPTILVHG----VSTVTS 938
            |.|..||..|...:||.|    |.|:.|
Zfish  1090 EFLEVLTEGLDHVLLVRGGGREVITIYS 1117

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10413	NP_609887.1	AA_permease_2	22..932	CDD:459263	272/1056 (26%)
slc12a7a	XP_005171306.1	AA_permease_2	62..1117	CDD:459263	275/1066 (26%)