DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10413 and NKCC

DIOPT Version :9

Sequence 1:	NP_001286048.1	Gene:	CG10413 / 35111	FlyBaseID:	FBgn0032689	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_730938.1	Gene:	NKCC / 40663	FlyBaseID:	FBgn0051547	Length:	1068	Species:	Drosophila melanogaster

Alignment Length:	1127	Identity:	280/1127 - (24%)
Similarity:	463/1127 - (41%)	Gaps:	274/1127 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SASAEQETA-----PIANSR------SGRTGS-------VFRSFGSLFGGSQNSGDRPHT----- 43
            ||.::|..|     |.:|..      ||.||.       .||.||:..  .::..:|..:
  Fly    24 SAESDQTDAAHPLPPTSNENHLHPKASGETGENRRSSRLSFRGFGNFL--RKSDAERKFSLAQLT 86

  Fly    44 -------------------PQDG-------DGYVEFGMQDPDRSGR--TLGTFAGVFSPVALSMF 80
                               |..|       |..:.....:|:.:|.  .||...||..|..|:::
  Fly    87 KESLPRLDNYRISMRNLKRPSIGELQGEAVDQSITIPEPEPEATGGHIKLGWIVGVLIPCLLNIW 151

  Fly    81 SALVFIRVGYIVGNAGLYVTLLQFLIAYGILLFTVASVCAISTNGAIEGGGVYFMISRTLGLEFG 145
            ..::|:|:.::|..:|:..:|:...|:..:.:.|..|:.||||||.::||||||:|||:||.|||
  Fly   152 GVMLFLRLSWVVAESGILQSLIIITISAVVCVITTLSLSAISTNGEVKGGGVYFIISRSLGPEFG 216

  Fly   146 GSIGTLFFFANVVGSAMAISGCTEG-----------IMDNFGPRGHFVSGDSHLPDGDWWRFLTS 199
            .|:|.:|.|||.|.::|...|..|.           |:||         |.:.:      |.:.|
  Fly   217 ASVGVVFAFANAVSASMNTIGFCESLNVLLKNNDLKIVDN---------GINDI------RIVGS 266

  Fly   200 SMINTLQLLVCLVGAALFAKTSVIILATVTVCLFATYFSFLFVGATNNTIPVPGDNILSNTTTFL 264
            ..:..| :|:|.||.....|....::.|:.:.:    |:|| :||...  |...:..:|.
  Fly   267 ITVLVL-ILICCVGMEWETKAQNFLIVTIVLAI----FNFL-IGAAIG--PQGNEEQISR----- 318

  Fly   265 DYTGLNATTLRDNLGSHYGRDYTSNGKQVDFSTTFGVLFSGVTGIMAGANMSGELKNPSKSIPYG 329
            .:.|.:..||::|.||.|   ..:.|...||.:.|.:.|..||||.||||:.|:||:...:||.|
  Fly   319 GFVGFSWATLKENFGSDY---RYAEGVNHDFFSVFAIFFPSVTGIQAGANICGDLKDAGAAIPKG 380

  Fly   330 TLSAVAFTFVSY--------------------------IILSFLM-----SCTTPYFTMQNNYLF 363
            |..::..:..||                          |:.|.|.     :||...|   |:|..
  Fly   381 TFWSLLISMSSYALFVLFAGGAAVRDASGIPADLVNGTIVSSELPCMATGNCTWGLF---NSYEM 442

  Fly   364 LMPVNLWPPFTAIGILTATFSTSLSNLIGSSRILEALSKDQVFGSLLNFVIHGTWKGNPIAAVAV 428
            :..::||.|....|...||.||:|:||:...|:::||..||::..|:.|.......|.|.....:
  Fly   443 MQEMSLWGPLIYAGCFAATLSTALTNLLSVPRLVQALGIDQIYPGLIFFSKPYGKHGEPYRGYVL 507

  Fly   429 SWCLVECILLIGSFNIIAQINSVLFMLSYLATNLACLGIELTGAPNFRPLFKFFTWHTCLVGLLG 493
            ::.:....||||..|:||.:.|..::.||...|.............:||.||::.....|.|...
  Fly   508 TFFITTGFLLIGELNLIAPLISTFYLASYALINFCTFHAAFVKPLGWRPTFKYYNAWLSLFGFAM 572

  Fly   494 TLIMMFVINFIYASSCIILCLILVIALHLF----SPATQAAQWGSISQALMFHQVRKYLLMLDPR 554
            .:.:||:||::.|    |:...::.||:|.    .|   .|.|||.:||..:......:..|...
  Fly   573 CVAIMFLINYVAA----IITFGIIFALYLVVMYRKP---EANWGSTTQAQQYKAALMAVHRLQNV 630

  Fly   555 KDHVKFWRPQILLLVSSPRSCCPLVDFVNDL-KKSGLYIIGH---VKLGDFKGIED-AEDNQQWW 614
            .||||.:.||:|:|...|::..|||||...| |.:.|..:.:   |::| :|..:. .:|.|:
  Fly   631 SDHVKNYHPQVLVLSGDPKTRPPLVDFGYLLTKNNSLMFVANIIPVRVG-YKNRQHLVKDGQK-- 692

  Fly   615 SFLDHMRVKAFTEVTLSRSIREGVQHLIRLSGIGAMKPNTIILGF-------------------Y 660
             :||..::|||..|....|:.:|:..|.:.:|.|.|.||.:::|:                   |
  Fly   693 -YLDARKIKAFYNVIDGFSLEDGINALTKSTGFGKMSPNIVLVGYKPDWNRCRKEEVESYFSILY 756

  Fly   661 DSEAPR------------DFFQ---------NGSSPYKTDD---FNNGEIQNFPIRRDGDPKQFQ 701
            ::.:.|            ||.:         ||.....|.:   |.|                 :
  Fly   757 NAFSQRMGVALLRLPNGLDFSELSSEVTLPANGMGHMHTANAHGFTN-----------------E 804

  Fly   702 IQEYVQILCDTLRMKKNLCLCR-----------------NFQRLDKNF-------ISMSKHVKYI 742
            :........:.|.:..||.|..                 |.||..:::       .:::.|.|..
  Fly   805 LMPAANAASELLHIDSNLNLASMDSPNSSFTMPQPAPMPNMQRNSRSYKVTSSDEPAVTYHTKGG 869

  Fly   743 DVWPINIFNP----TSGDPFDMVSLF----------MMQLAVIMLAKWKHLRVRIF-LCEANDER 792
            ...|.|:.:.    |...|...:.:|          ::...:.|.:.|::.::|:| :|...||.
  Fly   870 SDIPQNLLDAMTIFTRKQPKGTIDVFWLYDDGGLTILLPYIISMRSHWQNSKLRVFAMCHGKDEE 934

  Fly   793 TVGTFDTQTPQMEIFSKMKLEQSLKELRITADIVEIQEWSRDTDFSRHARTLKQFTAQADNVVLE 857
                 ..:.....:.:|.:::.|  ||.:   :..:.|..|.....:|.|.::.|...|.|....
  Fly   935 -----QEEKSMASLLTKFRIKYS--ELIM---LKGVSEQPRADTVLKHKRLIEPFRRGARNEFGI 989

  Fly   858 DDDEVG--EETLNRSLLYMQRANQIIRERSDQTALSFIYLAAPPK--LSAPDFAQRSASYMELLT 918
            .|||:.  .|..||.|    |.::::.:.|...:|..:.|..|.|  :|||       .||..|.
  Fly   990 TDDELQSMSEKTNRQL----RIHELVVKHSSNASLVVMSLPMPRKEAISAP-------LYMSWLE 1043

  Fly   919 ELTADLP-PTILVHGVSTVTST 939
            .||:|:. |..|..|..|...|
  Fly  1044 MLTSDMKCPVALARGNQTPVLT 1065

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10413	NP_001286048.1	2a30	22..932	CDD:273347	267/1087 (25%)
CG10413	NP_001286048.1	SLC12	577..932	CDD:281515	93/446 (21%)
NKCC	NP_730938.1	2a30	85..1068	CDD:273347	265/1064 (25%)
		DUF502	507..>643	CDD:294696	40/142 (28%)
		SLC12	651..1068	CDD:281515	96/457 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D20017at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11827
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.020