DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10413 and Slc12a4

DIOPT Version :9

Sequence 1:	NP_001286048.1	Gene:	CG10413 / 35111	FlyBaseID:	FBgn0032689	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_062102.1	Gene:	Slc12a4 / 29501	RGDID:	3687	Length:	1085	Species:	Rattus norvegicus

Alignment Length:	1119	Identity:	289/1119 - (25%)
Similarity:	459/1119 - (41%)	Gaps:	291/1119 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EQETAPIANSRSGRTGSVFRSFGSLFGGSQNSGDRPHTPQDGDGYVEFGMQDPDRSGRTLGTFAG 70
            |.:..|..:|..|:    ..|:.:|..|::...:    .:.|:|......:.|     ::||..|
  Rat    72 ELDIRPKVSSLLGK----LVSYTNLTQGAKEHEE----AESGEGGRRRAAKAP-----SMGTLMG 123

  Fly    71 VFSPVALSMFSALVFIRVGYIVGNAGLYVTLLQFLIAYGILLFTVASVCAISTNGAIEGGGVYFM 135
            |:.|...::|..::|:|:.::||.||:...||..||.....|.|..|:.||:|||.:..||.|||
  Rat   124 VYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFM 188

  Fly   136 ISRTLGLEFGGSIGTLFFFANVVGSAMAISGCTEGIMDNFG-PRGHFVSGDSHLPDGDWWRFLTS 199
            |||:||.||||::|..|:......:||.|.|..|.::.... |...|....:|        .::|
  Rat   189 ISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGTH--------DMSS 245

  Fly   200 SMIN----------TLQLLVCLVGAALFAKTSVIILATVTVCLFATY------------FSFLFV 242
            :.:|          |...||..||.....|.:.:.||.|.:.:.:.|            |....:
  Rat   246 ATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYVGGIKSAFDPPVFPVCML 310

  Fly   243 GATNNTI----------PVPGDN--------------------------ILSNTTTFLDYTGLNA 271
            |  |.|:          .|..||                          :|:|.|......|..|
  Rat   311 G--NRTLSRDQFDICAKTVVVDNETVATRLWTFFCHSPNLTADSCDPYFLLNNVTEIPGIPGAAA 373

  Fly   272 TTLRDNLGSHY---GRDYTSNG---------KQ-------VDFSTTF----GVLFSGVTGIMAGA 313
            ..|::||.|.|   |.....:|         |:       .|.:|:|    |:.|..|||||||:
  Rat   374 GVLQENLWSAYLEKGEVVEKHGLPSTDTLGLKESLSLYVVADIATSFTVLVGIFFPSVTGIMAGS 438

  Fly   314 NMSGELKNPSKSIPYGTLSAVAFTFVSYIILSFLMSCTTPYFTMQNNYLFLMPVNL------WP- 371
            |.||:|::..||||.||:.|:..|.:.|.....|.........:::.|...:..||      ||
  Rat   439 NRSGDLRDAQKSIPVGTILAIVTTSLVYFSSVILFGACIEGVVLRDKYGDGVSRNLVVGTLAWPS 503

  Fly   372 PFT-AIGILTATFSTSLSNLIGSSRILEALSKD------QVFGSLLNFVIHGTWKGNPIAAVAVS 429
            |:. .:|...:|....|.:|.|:.|:|:|::||      :|||       ||...|.|..|:.::
  Rat   504 PWVIVVGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFG-------HGKANGEPTWALLLT 561

  Fly   430 WCLVECILLIGSFNIIAQINSVLFMLSYLATNLACLGIELTGAPNFRPLFKFFTWHTCLVGLLGT 494
            ..:.|..:||.|.:::|.|.|:.|::.||..||||....|...||:||.||::.|....:|:...
  Rat   562 ALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLC 626

  Fly   495 LIMMFVINFIYASSCIILCLILVIALHLFSPATQA-AQWGSISQALMFHQVRKYLLMLDPRKDHV 558
            |.:|||.::.||    ::.:::...::.:.....| .:||...:.|.....|..||.|:....|.
  Rat   627 LALMFVSSWYYA----LVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHT 687

  Fly   559 KFWRPQILLL--------VSSPRSCCPLVDFVNDLKK-SGLYIIGHVKLGDF-KGIEDAEDNQQW 613
            |.||||:|:|        |..||    |:.|.:.||. .||.|:|.|..|.| :...:|:..:|.
  Rat   688 KNWRPQLLVLLKLDEDLHVKYPR----LLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQT 748

  Fly   614 -WSFLDHMRVKAFTEVTLSRSIREGVQHLIRLSGIGAMKPNTIILGFYDSEAPRDFFQNGSSPYK 677
             .:.::..:||.|.:|.::..:|||:.|||:..|:|.|:.|:::||:               ||.
  Rat   749 IKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGW---------------PYG 798

  Fly   678 TDDFNNGEIQNFPIRRDGDPKQFQIQEYVQILCDTLRMKKNLCLCRNFQRL----DKNF-ISMSK 737
            .             |:..||:.:      :...||:|       |.....|    .||. ...|.
  Rat   799 W-------------RQSEDPRAW------KTFIDTVR-------CTTAAHLALLVPKNIAFYPSN 837

  Fly   738 HVKY----IDVWPINIFNPTSGDPFDMVSLFMMQLAVIMLAKWKHLRVRIFLCEANDERTVGTFD 798
            |.:|    ||||.|    ...|....::...:.|..|     ||..|:|||        ||...|
  Rat   838 HERYLEGHIDVWWI----VHDGGMLMLLPFLLRQHKV-----WKKCRMRIF--------TVAQMD 885

  Fly   799 TQTPQMEIFSKMKLEQSLKELRITADIVEIQEWSRDTDFSRHARTL------------------- 844
            ..:.||    |..|...|..||:.|::..::..:.|.....:.|||
  Rat   886 DNSIQM----KKDLAIFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTER 946

  Fly   845 ---------KQFTAQADNVVLEDDDE--VGEETLN----------------------RSLLYMQ- 875
                     :....:.:::..:::||  .|.:.:.                      |.|::::
  Rat   947 DREAQLVKDRHSALRLESLYSDEEDESVTGADKIQMTWTRDKYMAEPWDPSHAPDNFRELVHIKP 1011

  Fly   876 ------------RANQIIRERSDQTALSFIYLAAPPKLSAPDFAQRSASYMELLTELTADLPPTI 928
                        :.|::|..||....|..:.:..|||.|..|     .:|||.|..||..|...:
  Rat  1012 DQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPKNSEGD-----ENYMEFLEVLTEGLERVL 1071

  Fly   929 LVHG----VSTVTS 938
            ||.|    |.|:.|
  Rat  1072 LVRGGGREVITIYS 1085

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10413	NP_001286048.1	2a30	22..932	CDD:273347	281/1091 (26%)
CG10413	NP_001286048.1	SLC12	577..932	CDD:281515	97/431 (23%)
Slc12a4	NP_062102.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	32..56
		2a30	42..1085	CDD:273347	288/1117 (26%)
		SLC5-6-like_sbd	142..>303	CDD:294310	52/168 (31%)
		SLC12	709..1085	CDD:281515	102/446 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352214
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840