DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10413 and Slc12a1

DIOPT Version :9

Sequence 1:	NP_001286048.1	Gene:	CG10413 / 35111	FlyBaseID:	FBgn0032689	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_001257546.1	Gene:	Slc12a1 / 25065	RGDID:	3685	Length:	1095	Species:	Rattus norvegicus

Alignment Length:	1048	Identity:	263/1048 - (25%)
Similarity:	445/1048 - (42%)	Gaps:	212/1048 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 FRSFGSLFGGSQN--------------------SGDR-------------PHTPQDGDGYVEFGM 55
            :|:.||:.|...|                    |.||             .:..:|..|.|:||.
  Rat   111 YRNTGSVSGPKVNRPSLQEIHEQLAKNVAVAPGSADRVANGDGMPGDEQAENKEEDVTGVVKFGW 175

  Fly    56 QDPDRSGRTLGTFAGVFSPVALSMFSALVFIRVGYIVGNAGLYVTLLQFLIAYGILLFTVASVCA 120
                        ..||.....|:::..::|||:.:|||.||:.:.:|..|::..:...|..|..|
  Rat   176 ------------VKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSA 228

  Fly   121 ISTNGAIEGGGVYFMISRTLGLEFGGSIGTLFFFANVVGSAMAISGCTEGIMDNFGPRGHFVSGD 185
            |:|||.:.|||.|::|||:||.|||||||.:|.|||.|..||.:.|..|.::|      .....|
  Rat   229 IATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVD------LLKESD 287

  Fly   186 SHLPDGDWWRFLTSSMINTLQLLVCLVGAALFAKTSVIILATVTVCLFATYFSFLFVGATNNTIP 250
            |.:.|......:..|:...:.|.:.:.|....||..||:|..:.:.:     :..|:|..
  Rat   288 SMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAI-----ANFFIGTV----- 342

  Fly   251 VPGDNILSNTTTFLDYTGLNATTLRDNLGSHYGRDYTSNGKQVDFSTTFGVLFSGVTGIMAGANM 315
            :|.:| ...:..|.:|   .|:...:|.|..:     :.|:  .|.:.|.:.|...|||:||||:
  Rat   343 IPSNN-EKKSRGFFNY---QASIFAENFGPSF-----TEGE--GFFSVFAIFFPAATGILAGANI 396

  Fly   316 SGELKNPSKSIPYGTLSAVAFTFVSYIILSFLM--------------------------SCTTPY 354
            ||:|::|..:||.||:.|:..|.|:||.::..:                          :|...|
  Rat   397 SGDLEDPQDAIPRGTMLAIFITTVAYIGVAICVAACVVRDATGSMNDTVVSGMNCNGSAACGLGY 461

  Fly   355 -----------FTMQNNYLFLMPVNLWPPFTAIGILTATFSTSLSNLIGSSRILEALSKDQVFGS 408
                       :.:.||:..:..|:.:.|....||.:||.|::|::|:.:.::.:||.||.:|..
  Rat   462 DFSRCQHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIFKG 526

  Fly   409 LLNFVIHGTWKGN-PIAAVAVSWCLVECILLIGSFNIIAQINSVLFMLSYLATNLACLGIELTGA 472
             |.|...|..|.| |:....:::.:....:||...|:||.|.|..|:.||...|.:|.......:
  Rat   527 -LQFFAKGYGKNNEPLRGYFLTFVIAMAFILIAELNVIAPIISNFFLASYALINFSCFHASYAKS 590

  Fly   473 PNFRPLFKFFTWHTCLVGLLGTLIMMFVINFIYASSCIILCLILVIALHLFSPATQAAQWGSISQ 537
            |.:||.:..:.....|.|.:....:|||||:..|....::.|.|.|.:....|   ...|||.:|
  Rat   591 PGWRPAYGIYNMWVSLFGAILCCAVMFVINWWAAVITYVIELFLYIYVTYKKP---DVNWGSSTQ 652

  Fly   538 ALMFHQVRKYLLMLDPRKDHVKFWRPQILLLVSSPRSCCPLVDFVNDL-KKSGLYIIGHVKLGD- 600
            ||.:.......|.|...:||||.:|||.::|...|.:...|:|..:.. |.|||.|...|.:|.
  Rat   653 ALSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPR 717

  Fly   601 ---FKGIEDAEDNQQWWSFLDHMRVKAFTEVTLSRSIREGVQHLIRLSGIGAMKPNTIILGFYDS 662
               .|.:......:|.|  |...::|||.....:...|:||:.|::.||:|.|||||:::|:..:
  Rat   718 KLCVKEMNSGMAKKQAW--LMKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKN 780

  Fly   663 --EAPRDFFQN-GSSPYKTDDFNNGEI-----QNF---PIRRDGDPKQFQIQEYVQILCDTLRMK 716
              :||....:| ....:...||..|.:     |.|   |:.:..|..:...||.:.:   ...:|
  Rat   781 WRKAPLSELENYVGIIHDAFDFEIGVVIVRISQGFDISPVLQVQDELEKLEQERLAL---EAAIK 842

  Fly   717 KNLC------------------LCRNFQRLDKNFISM-SKHV--------------------KYI 742
            .|.|                  :.:...:.|.|..:: |.||                    ..|
  Rat   843 DNDCEEGKGGIRGLFKKAGKLNITKPAPKKDSNISTIQSMHVGEFNQKLVEASAQFKKKQGKGTI 907

  Fly   743 DVWPINIFNPTSGDPFDMVSLFMMQLAVIML-AKWKHLRVRIF----LCEANDER-----TVGTF 797
            |||.:          ||...|.::...::.| .|||..::||:    :....:|:     .:..|
  Rat   908 DVWWL----------FDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKISMASLLSKF 962

  Fly   798 DTQTPQMEIFSKMKLEQSLKELRITADIVE---IQEWSRDTDFSRHARTLKQFTAQADNVVLEDD 859
            ..:...:.|...:.::.:.:..::..:::|   :.|..:|      ..|.::...::...:.:.:
  Rat   963 RIKFADIHIIGDINIKPNKESWKVFEEMIEPYRLHESHKD------LTTAEKLKRESPWKITDAE 1021

  Fly   860 DEVGEETLNRSLLYMQRANQIIRERSDQTALSFIYLAAPPKLSAPDFAQRSASYMELLTELTADL 924
            .|..:|...|.:    |.|::::|.|....|..:.|....|.|..|..     ||..|..||.:|
  Rat  1022 LEAVKEKSYRQV----RLNELLQEHSRAANLIVLSLPVARKGSISDLL-----YMAWLEILTKNL 1077

  Fly   925 PPTILVHG 932
            ||.:||.|
  Rat  1078 PPVLLVRG 1085

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10413	NP_001286048.1	2a30	22..932	CDD:273347	262/1046 (25%)
CG10413	NP_001286048.1	SLC12	577..932	CDD:281515	91/422 (22%)
Slc12a1	NP_001257546.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..45
		AA_permease_N	86..152	CDD:285588	8/40 (20%)
		2a30	100..1095	CDD:273347	263/1048 (25%)
		SLC12	690..1095	CDD:281515	92/426 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352223
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840