DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10413 and Slc12a7

DIOPT Version :9

Sequence 1:	NP_001286048.1	Gene:	CG10413 / 35111	FlyBaseID:	FBgn0032689	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	XP_006517233.1	Gene:	Slc12a7 / 20499	MGIID:	1342283	Length:	1117	Species:	Mus musculus

Alignment Length:	1071	Identity:	272/1071 - (25%)
Similarity:	436/1071 - (40%)	Gaps:	261/1071 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 GYVEFGMQDPDRSGR-----TLGTFAGVFSPVALSMFSALVFIRVGYIVGNAGLYVTLLQFLIAY 108
            |.||. .:|.|...|     .:|||.||:.|...::...::|:|:.:|||.||:..:.|...:..
Mouse   127 GVVEH-EEDEDSRRREVKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGAAGVMESFLIVAMCC 190

  Fly   109 GILLFTVASVCAISTNGAIEGGGVYFMISRTLGLEFGGSIGTLFFFANVVGSAMAISGCTEGIMD 173
            ...:.|..|:.||:|||.:..||.|:||||:||.||||::|..|:.......||.|.|..|..:.
Mouse   191 TCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLT 255

  Fly   174 NFGPRGHFVSGDSHLPDGDWWRFLTSSMINTLQL----------LVCLVGAALFAKTSVIILATV 228
            ...|.......::  .||:     .::::|.:::          :|..||.....|.:::.||.|
Mouse   256 YISPSAAIFQAET--ADGE-----AAALLNNMRVYGSCALALMAVVVFVGVKYVNKLALVFLACV 313

  Fly   229 TVCLFATYFSFLFVGATNNTIPV--PGDNILSN-----------------TTT----FLDYTGLN 270
            .:.:.|.|...:........|||  .|:..|:|                 ||.    |.:.:.|.
Mouse   314 VLSILAIYAGVIKTAFAPPDIPVCLLGNRTLANRNFDTCAKMQVVSNGTVTTALWRLFCNGSSLG 378

  Fly   271 AT----------------------TLRDNLGSHY------------------------GRDYTSN 289
            ||                      ...|||.|.|                        |..|...
Mouse   379 ATCDEYFAQNNVTEIQGIPGVASGVFLDNLWSTYSDKGAFVEKKGVSSVPVSEESRPGGLPYVLT 443

  Fly   290 GKQVDFSTTFGVLFSGVTGIMAGANMSGELKNPSKSIPYGTLSAVAFTFVSYIILSFLMSCTTPY 354
            .....|:...|:.|..|||||||:|.||:||:..||||.||:.|:..|...|:....|.......
Mouse   444 DIMTYFTMLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEG 508

  Fly   355 FTMQNNYLFLMPVNL------WP-PFT-AIGILTATFSTSLSNLIGSSRILEALSKD------QV 405
            ..:::.:...:..||      || |:. .||...:|....|.:|.|:.|:|:|:::|      ||
Mouse   509 VVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIIPFLQV 573

  Fly   406 FGSLLNFVIHGTWKGNPIAAVAVSWCLVECILLIGSFNIIAQINSVLFMLSYLATNLACLGIELT 470
            ||       ||...|.|..|:.::..:.|..:||.|.:.:|.|.|:.|::.|:..||||....|.
Mouse   574 FG-------HGKANGEPTWALLLTALICETGILIASLDSVAPILSMFFLMCYMFVNLACAVQTLL 631

  Fly   471 GAPNFRPLFKFFTWHTCLVGLLGTLIMMFVINFIYASSCIIL--CLILVIALHLFSPATQAAQWG 533
            ..||:||.|||:.|....:|:...|.:||:.::.||...:::  |:...|.   :..|.:  :||
Mouse   632 RTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALFAMLIAGCIYKYIE---YRGAEK--EWG 691

  Fly   534 SISQALMFHQVRKYLLMLDPRKDHVKFWRPQILLLVSSPRSCC----PLVDFVNDLKK-SGLYII 593
            ...:.|..:..|..||.::....|.|.||||:|::::.....|    .|:.|.:.||. .||.|:
Mouse   692 DGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDSEQCVKHPRLLSFTSQLKAGKGLTIV 756

  Fly   594 GHVKLGDF--KGIE--DAEDNQQWWSFLDHMRVKAFTEVTLSRSIREGVQHLIRLSGIGAMKPNT 654
            |.|..|.:  |.:|  .||:|.:  |.:...:.|.|.::.:|.::|:|..|||:.:|:|.||.||
Mouse   757 GSVLEGTYLDKHVEAQRAEENIR--SLMSAEKTKGFCQLVVSSNLRDGASHLIQSAGLGGMKHNT 819

  Fly   655 IILGFYDSEAPRDFFQNGSSPYKTDDFNNGEIQNFPIRRDGDPKQFQIQEYVQILCDTLRMKKNL 719
            :::.:.::      ::...:|                        |..:.:|..:.||....:.|
Mouse   820 VLMAWPEA------WKEADNP------------------------FSWKNFVDTVRDTTAAHQAL 854

  Fly   720 CLCRNFQRLDKNFISMSKHVKYIDVWPINIFNPTSGDPFDMVSLFMMQLAVIMLAKWKHLRVRIF 784
            .:.:|.....:|....|.  ..||||.|    ...|....::...:.|..|     |:..|:|||
Mouse   855 LVAKNIDLFPQNQERFSD--GNIDVWWI----VHDGGMLMLLPFLLRQHKV-----WRKCRMRIF 908

  Fly   785 LCEANDERTVGTFDTQTPQMEIFSKMKLEQSLKELRITA--DIVEIQE-------WSRDTDFSRH 840
                    ||...|..:.||    |..|:..|..|||:|  ::||:.|       :.:.....:.
Mouse   909 --------TVAQVDDNSIQM----KKDLQMFLYHLRISAEVEVVEMVENDISAFTYEKTLMMEQR 961

  Fly   841 ARTLKQF-----------------------TAQA--------DNVVLEDDDE--VGEETLN---- 868
            ::.|||.                       ||.|        |.|.:....|  :.|:..|
Mouse   962 SQMLKQMQLSKNEREREAQLIHDRNTASHTTATARTQAPPTPDKVQMTWTKEKLIAEKHRNKDTG 1026

  Fly   869 ----------------------RSLLYMQRANQIIRERSDQTALSFIYLAAPPKLSAPDFAQRSA 911
                                  |.:....:.|.::..:|....|..:.:..|||     ..|...
Mouse  1027 PSGFKDLFSLKPEWGNLDQSNVRRMHTAVKLNGVVLNKSQDAQLVLLNMPGPPK-----SRQGDE 1086

  Fly   912 SYMELLTELTADLPPTILVHG----VSTVTS 938
            :|||.|..||..|...:||.|    |.|:.|
Mouse  1087 NYMEFLEVLTEGLNRVLLVRGGGREVITIYS 1117

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10413	NP_001286048.1	2a30	22..932	CDD:273347	268/1059 (25%)
CG10413	NP_001286048.1	SLC12	577..932	CDD:281515	95/427 (22%)
Slc12a7	XP_006517233.1	2a30	74..1117	CDD:273347	271/1069 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848625
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840