Protein Alignment CG10413 and Slc12a4

DIOPT Version :10

• Sequence 1: NP_609887.1
• Gene: CG10413 / 35111
• FlyBaseID: FBgn0032689
• Length: 941
• Species: Drosophila melanogaster
• Sequence 2: NP_001240733.1
• Gene: Slc12a4 / 20498
• MGIID: 1309465
• Length: 1087
• Species: Mus musculus
• Alignment Length: 1118
• Identity: 295/1118 - (26%)
• Similarity: 452/1118 - (40%)
• Gaps: 289/1118 - (25%)

  Fly     6 EQETAPIANSRSGRTGSVFRSFGSLFGGSQNSGDRPHTPQDGDGYVEFGMQDPDRSGRTLGTFAG 70
            |.:..|..:|..|:    ..|:.:|..|::...:    .:.|:|......:.|     ::||..|
Mouse    74 ELDIRPKVSSLLGK----LVSYTNLTQGAKEHEE----AESGEGGRRRAAKAP-----SMGTLMG 125

  Fly    71 VFSPVALSMFSALVFIRVGYIVGNAGLYVTLLQFLIAYGILLFTVASVCAISTNGAIEGGGVYFM 135
            |:.|...::|..::|:|:.::||.||:...||..||.....|.|..|:.||:|||.:..||.|||
Mouse   126 VYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFM 190

  Fly   136 ISRTLGLEFGGSIGTLFFFANVVGSAMAISGCTEGIMDNFG-PRGHFVSGDSHLPDGDWWRFLTS 199
            |||:||.||||::|..|:......:||.|.|..|.::.... |...|....:|        .::|
Mouse   191 ISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGTH--------DMSS 247

  Fly   200 SMIN----------TLQLLVCLVGAALFAKTSVIILATVTVCLFATY------------FSFLFV 242
            :.:|          ||..||..||.....|.:.:.||.|.:.:.:.|            |....:
Mouse   248 ATLNNMRVYGTIFLTLMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCML 312

  Fly   243 GATNNTI----------PVPGDN--------------------------ILSNTTTFLDYTGLNA 271
            |  |.|:          .|..||                          :|:|.|......|..|
Mouse   313 G--NRTLSRDQFDICAKTVVVDNETVATRLWTFFCHSPNLTADSCDPYFLLNNVTEIPGIPGAAA 375

  Fly   272 TTLRDNLGSHY---GRDYTSNG---------KQ-------VDFSTTF----GVLFSGVTGIMAGA 313
            ..|::||.|.|   |.....:|         |:       .|.:|:|    |:.|..|||||||:
Mouse   376 GVLQENLWSAYLEKGEVVEKHGLPSTDTLGLKESLSLYVVADIATSFTVLVGIFFPSVTGIMAGS 440

  Fly   314 NMSGELKNPSKSIPYGTLSAVAFTFVSYIILSFLMSCTTPYFTMQNNYLFLMPVNL------WP- 371
            |.||:|::..||||.||:.|:..|.:.|.....|.........:::.|...:..||      ||
Mouse   441 NRSGDLRDAQKSIPVGTILAIVTTSLVYFSSVILFGACIEGVVLRDKYGDGVSRNLVVGTLAWPS 505

  Fly   372 PFT-AIGILTATFSTSLSNLIGSSRILEALSKD------QVFGSLLNFVIHGTWKGNPIAAVAVS 429
            |:. .:|...:|....|.:|.|:.|:|:|::||      :|||       ||...|.|..|:.::
Mouse   506 PWVIVVGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFG-------HGKANGEPTWALLLT 563

  Fly   430 WCLVECILLIGSFNIIAQINSVLFMLSYLATNLACLGIELTGAPNFRPLFKFFTWHTCLVGLLGT 494
            ..:.|..:||.|.:::|.|.|:.|::.||..||||....|...||:||.||::.|....:|:...
Mouse   564 ALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWTLSFLGMSLC 628

  Fly   495 LIMMFVINFIYASSCIILCLILVIALHLFSPATQAAQWGSISQALMFHQVRKYLLMLDPRKDHVK 559
            |.:|||.::.||   ::..||..:............:||...:.|.....|..||.|:....|.|
Mouse   629 LALMFVSSWYYA---LVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTK 690

  Fly   560 FWRPQILLL--------VSSPRSCCPLVDFVNDLKK-SGLYIIGHVKLGDF-KGIEDAEDNQQW- 613
            .||||:|:|        |..||    |:.|.:.||. .||.|:|.|..|.| :...:|:..:|.
Mouse   691 NWRPQLLVLLKLDEDLHVKYPR----LLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTI 751

  Fly   614 WSFLDHMRVKAFTEVTLSRSIREGVQHLIRLSGIGAMKPNTIILGFYDSEAPRDFFQNGSSPYKT 678
            .:.:|..:||.|.:|.::..:|||:.|||:..|:|.|:.|:::||:               ||..
Mouse   752 KNMMDIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGW---------------PYGW 801

  Fly   679 DDFNNGEIQNFPIRRDGDPKQFQIQEYVQILCDTLRMKKNLCLCRNFQRL----DKNF-ISMSKH 738
                         |:..||:.:      :...||:|       |.....|    .||. ...|.|
Mouse   802 -------------RQSEDPRAW------KTFIDTVR-------CTTAAHLALLVPKNIAFYPSNH 840

  Fly   739 VKY----IDVWPINIFNPTSGDPFDMVSLFMMQLAVIMLAKWKHLRVRIFLCEANDERTVGTFDT 799
            .:|    ||||.|    ...|....::...:.|..|     ||..|:|||        ||...|.
Mouse   841 ERYLDGHIDVWWI----VHDGGMLMLLPFLLRQHKV-----WKKCRMRIF--------TVAQMDD 888

  Fly   800 QTPQMEIFSKMKLEQSLKELRITADIVEIQEWSRD--------------------------TDFS 838
            .:.||    |..|...|..||:.|::..::..:.|                          |:..
Mouse   889 NSIQM----KKDLAIFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTERD 949

  Fly   839 RHARTLK--------------------------QFTAQADNVVLEDDDEVGEETLNRSLLYMQ-- 875
            |.|:.:|                          |.|...|..:.|..|........|.|::::
Mouse   950 REAQLVKDRHSALRLESLYSDEEEESVAGADKIQMTWTRDKYMAEPWDPSHAPDNFRELVHIKPD 1014

  Fly   876 -----------RANQIIRERSDQTALSFIYLAAPPKLSAPDFAQRSASYMELLTELTADLPPTIL 929
                       :.|::|..||....|..:.:..|||.|..|     .:|||.|..||..|...:|
Mouse  1015 QSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPKNSEGD-----ENYMEFLEVLTEGLERVLL 1074

  Fly   930 VHG----VSTVTS 938
            |.|    |.|:.|
Mouse  1075 VRGGGREVITIYS 1087

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10413	NP_609887.1	AA_permease_2	22..932	CDD:459263	287/1090 (26%)
Slc12a4	NP_001240733.1	2a30	44..1087	CDD:273347	294/1116 (26%)
		Scissor helix. /evidence=ECO:0000250|UniProtKB:Q9UP95	667..683		4/15 (27%)