Protein Alignment CG10413 and Slc12a3

DIOPT Version :10

• Sequence 1: NP_609887.1
• Gene: CG10413 / 35111
• FlyBaseID: FBgn0032689
• Length: 941
• Species: Drosophila melanogaster
• Sequence 2: XP_017168114.1
• Gene: Slc12a3 / 20497
• MGIID: 108114
• Length: 1009
• Species: Mus musculus
• Alignment Length: 999
• Identity: 251/999 - (25%)
• Similarity: 422/999 - (42%)
• Gaps: 227/999 - (22%)

  Fly    48 DGYVEFGMQDPDRSGRT----------LGTFAGVFSPVALSMFSALVFIRVGYIVGNAGLYVTLL 102
            ||.||      |.:|..          .|...||.....|:::..::::|:.:|...||:.:|.|
Mouse   113 DGLVE------DETGTNSEKSPGEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWL 171

  Fly   103 QFLIAYGILLFTVASVCAISTNGAIEGGGVYFMISRTLGLEFGGSIGTLFFFANVVGSAMAISGC 167
            ..|::..:...|..|:.||||||.::.||.||:|||:||.|.|||||.:|.|||.||.||...|.
Mouse   172 IILLSVMVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 236

  Fly   168 TEGIMD----------NFGPRGHFVSGDSHLPDGDWWRFLTSSMIN----------TLQLLVCLV 212
            .|.:.|          .:|           .|..|        .||          |:.|.:.|.
Mouse   237 AETVRDLLQLACSPTQEYG-----------TPIVD--------PINDIRIIGVVTVTVLLAISLA 282

  Fly   213 GAALFAKTSVIILATVTVCLFATYFSFLFVGATNNT-----IPVPGDNILSNTTTFLDYTGLNAT 272
            |....:|..|:....:.|. ||.|.....:.|:.:.     ....||..:.|...  |:.|::
Mouse   283 GMEWESKAQVLFFLVIMVS-FANYLVGTLIPASEDKASKGFYSYHGDIFVQNLVP--DWRGID-- 342

  Fly   273 TLRDNLGSHYGRDYTSNGKQVDFSTTFGVLFSGVTGIMAGANMSGELKNPSKSIPYGTLSAVAFT 337
                  ||.:|              .|.:.|...|||:||||:||:||:|:.:||.|||.|:.:|
Mouse   343 ------GSFFG--------------MFSIFFPSATGILAGANISGDLKDPAVAIPKGTLMAIFWT 387

  Fly   338 FVSYIILSFLM-SCT------------TP--------------YFT-----------MQNNYLFL 364
            .:||:.:|..: ||.            ||              .||           :.|.|..:
Mouse   388 TISYLAISATIGSCVVRDASGDVNDTMTPGPGPCEGLACGYGWNFTECSQQRSCRYGLINYYQTM 452

  Fly   365 MPVNLWPPFTAIGILTATFSTSLSNLIGSSRILEALSKDQVFGSLLNFVIHGTWKG-NPIAAVAV 428
            ..|:.:.|....||..||.|::|:.|:.::::.:.|.:||:: .|:.|...|..|. .|:....:
Mouse   453 SMVSAFAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLY-PLIGFFGKGYGKNREPVRGYLL 516

  Fly   429 SWCLVECILLIGSFNIIAQINSVLFMLSYLATNLACLGIELTGAPNFRPLFKFFTWHTCLVGLLG 493
            ::.:....::|...|.||.|.|..|:.||...|.:|....:|.:|.:||.|::::....|.|.:.
Mouse   517 AYAIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFRYYSKWAALFGAVI 581

  Fly   494 TLIMMFVINFIYASSCIILCLILVIALHLFSPATQAAQWGSISQALMFHQVRKYLLMLDPRKDHV 558
            ::::||::.:..|...|.:.|.|::.:....|   ...|||..||..::....|.:.|:..:||:
Mouse   582 SVVIMFLLTWWAALIAIGVVLFLLLYVIYKKP---EVNWGSSVQAGSYNLALSYSVGLNEVEDHI 643

  Fly   559 KFWRPQILLLVSSPRSCCPLVDFVNDLKKS-GLYIIGHVKLGDFK-GIED----AEDNQQWWSFL 617
            |.:|||.|:|...|.....|||||:...:: .|.|.|||.:|..| .:.:    |..:.:|   |
Mouse   644 KNYRPQCLVLTGPPNFRPALVDFVSTFTQNLSLMICGHVLIGPGKQRVPELRLIASGHTKW---L 705

  Fly   618 DHMRVKAFTEVTLSRSIREGVQHLIRLSGIGAMKPNTIILGFYDSEAPRDFFQNGSSPYKTDDFN 682
            :..::|||....::..:|.|||.|::.||:|.||||.:::||.         :|..|.:..
Mouse   706 NKRKIKAFYSDVIAEDLRSGVQILMQASGLGRMKPNILVVGFK---------RNWQSAHPA---- 757

  Fly   683 NGEIQNFPIRRDGDPKQFQIQEYVQILCDTLRMKKNLCLCRNFQRLD------------------ 729
                              .:::|:.:|.|.......:|:.|..:.|:
Mouse   758 ------------------TVEDYIGVLHDAFDFNYGVCVMRMREGLNVSEALQTHTTPEALIQEE 804

  Fly   730 --KNFISMSKHVKYIDVWPINIFNPTSGDPFDMVSLFMMQLAVIMLAK-WKHLRVRIF----LCE 787
              .......:..|.||::.:          ||...|.::...::...| |...::|:|    :..
Mouse   805 QASTIFQSEQGKKTIDIYWL----------FDDGGLTLLIPYLLHRKKRWGKCKIRVFVGGQINR 859

  Fly   788 ANDERTVGTFDTQTPQMEIFSKMKLEQSLKELRITADI---VEIQEWSRDTDFSRHARTLKQFTA 849
            .::||..        .:.:.||.:|  ...|:.:..||   .:.:...|..|.....|....|..
Mouse   860 MDEERKA--------IISLLSKFRL--GFHEVHVLPDINQKPQAEHTKRFEDMIAPFRLNDGFKD 914

  Fly   850 QADNVVLEDDD--EVGEETLNRS---LLYMQRANQIIRERSDQTALSFIYLAAPPKLSAPDFAQR 909
            :|....:..|.  ::.:|.:|::   .|...|.::|:.:.|...||..:.|....|...|
Mouse   915 EATVTEMRRDCPWKISDEEINKNRIKSLRQVRLSEILLDYSRDAALIILTLPIGRKGKCP----- 974

  Fly   910 SASYMELLTELTADL-PPTILVHG 932
            |:.||..|..|:.|| ||.:|:.|
Mouse   975 SSLYMAWLETLSQDLRPPVLLIRG 998

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10413	NP_609887.1	AA_permease_2	22..932	CDD:459263	250/997 (25%)
Slc12a3	XP_017168114.1	2a30	57..1008	CDD:273347	251/999 (25%)