Protein Alignment CG10413 and Slc12a2

DIOPT Version :10

• Sequence 1: NP_609887.1
• Gene: CG10413 / 35111
• FlyBaseID: FBgn0032689
• Length: 941
• Species: Drosophila melanogaster
• Sequence 2: NP_033220.2
• Gene: Slc12a2 / 20496
• MGIID: 101924
• Length: 1206
• Species: Mus musculus
• Alignment Length: 1025
• Identity: 258/1025 - (25%)
• Similarity: 447/1025 - (43%)
• Gaps: 238/1025 - (23%)

  Fly    46 DGDGYVEFGMQDPDRSGRTLGTFAGVFSPVALSMFSALVFIRVGYIVGNAGLYVTLLQFLIAYGI 110
            :..|.|:||.            ..||.....|:::..::|||:.:|||.||:.::::...:|..:
Mouse   272 ESKGVVKFGW------------IKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVVVIAMATVV 324

  Fly   111 LLFTVASVCAISTNGAIEGGGVYFMISRTLGLEFGGSIGTLFFFANVVGSAMAISGCTEGIMDNF 175
            ...|..|..||:|||.:.|||.|::|||:||.||||:||.:|.|||.|..||.:.|..|.:::..
Mouse   325 TTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELL 389

  Fly   176 GPRGHFVSGDSHLPDGDWWRFLTSSMINTLQLL-----VCLVGAALF-----AKTSVIILATVTV 230
              :.|.:              |....||.::::     |.|:|.::.     ||..:::|..:.:
Mouse   390 --KEHSI--------------LMIDEINDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLL 438

  Fly   231 CLFATYFSFLFVGATNNTIPVPGDNILSNTTTFLD--------YTGLNATTLRDNLGSHYGRDYT 287
            .:                    .|.::.   ||:.        :.|..:....:|.|..:..:.|
Mouse   439 AI--------------------ADFVIG---TFISLESKKPKGFFGYKSEIFNENFGPDFREEET 480

  Fly   288 SNGKQVDFSTTFGVLFSGVTGIMAGANMSGELKNPSKSIPYGTLSAVAFTFVSYI---------- 342
                   |.:.|.:.|...|||:||||:||:|.:|..:||.|||.|:..|.|.||
Mouse   481 -------FFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTVVYIGIAVSVGSCV 538

  Fly   343 -----------ILSFLMSCT----------------TPYFTMQNNYLFLMPVNLWPPFTAIGILT 380
                       |.:.|.:||                |..:.:.||:..:..|:.:.|..:.||.:
Mouse   539 VRDATGNVNDTITTELTNCTSAACKLNFDFSYCESNTCSYGLMNNFQVMSMVSGFAPLISAGIFS 603

  Fly   381 ATFSTSLSNLIGSSRILEALSKDQVFGSLLNFVIHGTWKGN-PIAAVAVSWCLVECILLIGSFNI 444
            ||.|::|::|:.:.:|.:||.||.::.:...|. .|..|.| |:....:::.:....:||...|:
Mouse   604 ATLSSALASLVSAPKIFQALCKDNIYPAFQMFA-KGYGKNNEPLRGYILTFLIALGFILIAELNV 667

  Fly   445 IAQINSVLFMLSYLATNLACLGIELTGAPNFRPLFKFFTWHTCLVGLLGTLIMMFVINFIYASSC 509
            ||.|.|..|:.||...|.:.....|..:|.:||.||::.....|:|.:...|:|||||:..|
Mouse   668 IAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLIGAILCCIVMFVINWWAA--- 729

  Fly   510 IILCLILVIALHLFSPATQA-AQWGSISQALMFHQVRKYLLMLDPRKDHVKFWRPQILLLVSSPR 573
             :|..::|:.|:::....:. ..|||.:|||.:....::.:.|...:||||.:|||.|::..||.
Mouse   730 -LLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLSALQHSIRLSGVEDHVKNFRPQCLVMTGSPN 793

  Fly   574 SCCPLVDFVNDLKKS-GLYIIGHVKLGDFKGI--EDAEDNQQWWSFLDHMRVKAFTEVTLSRSIR 635
            |...|:..|:|..|: ||.|.|||.:|..:..  |.:.|..::..:|...::|||.....:..:|
Mouse   794 SRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMSIDQARYQRWLIKNKMKAFYAPVHADDLR 858

  Fly   636 EGVQHLIRLSGIGAMKPNTIILGFYDSEAPRDFFQNGSSPYKTDDFNNGEIQNFPIR-------- 692
            ||.|:|::.:|:|.|||||::|||     .:|:.|  :.....|.:.|.....|.|:
Mouse   859 EGAQYLMQAAGLGRMKPNTLVLGF-----KKDWLQ--ADMRDVDMYINLFHDAFDIQFGVVVIRL 916

  Fly   693 RDG-DPKQFQIQEYVQILCDTLRMKKNLCLCRNFQRLDKNFISMSKHVKYI-------------- 742
            ::| |....|.||.:....:.....|::.:..::.:........|...|.|
Mouse   917 KEGLDISHLQGQEELLSSQEKSPGTKDVVVNVDYSKKSDQDTCKSSGEKSITQKDEEEDGKTPTQ 981

  Fly   743 ---------DVWPINI-----------FNPTSG-DPFDMVSLF-------MMQLAVIMLAKWKHL 779
                     .:.|:|:           |....| :..|:..||       ::...:....|||..
Mouse   982 PLLKKESKGPIVPLNVADQKLLEASTQFQKKQGKNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDC 1046

  Fly   780 RVRIFLCEA-----NDERTVGTFDTQTPQMEIFSKMKLEQSLKELRITADIVEIQEWSRDTDFSR 839
            ::|:|:...     :|.|.:.|         :.||.:::.|  ::.:..||
Mouse  1047 KIRVFIGGKINRIDHDRRAMAT---------LLSKFRIDFS--DIMVLGDI-------------- 1086

  Fly   840 HARTLKQFTAQADNVV----LEDDDEV-----------------GEETLNRSLLYMQ-RANQIIR 882
            :.:..|:.....|:::    |.:||:.                 .|..|.::..|.| |.|::::
Mouse  1087 NTKPKKENIIAFDDMIEPYRLHEDDKEQDIADKMKEDEPWRITDNELELYKTKTYRQIRLNELLK 1151

  Fly   883 ERSDQTALSFIYLAAPPKLSAPDFAQRSASYMELLTELTADLPPTILVHG 932
            |.|  :..:.|.::.|   .|...|..||.||..|..|:.||||.:||.|
Mouse  1152 EHS--STANIIVMSLP---VARKGAVSSALYMAWLEALSKDLPPVLLVRG 1196

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10413	NP_609887.1	AA_permease_2	22..932	CDD:459263	257/1023 (25%)
Slc12a2	NP_033220.2	PRK07764	<3..74	CDD:236090
		RFXV motif 1. /evidence=ECO:0000269|PubMed:14563843	78..81
		RFXV motif 2. /evidence=ECO:0000269|PubMed:14563843	134..137
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	144..188
		2a30	210..1206	CDD:273347	258/1025 (25%)
		Scissor helix. /evidence=ECO:0000250|UniProtKB:P55011	755..772		3/16 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	954..987		3/32 (9%)