DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10413 and kcc-2

DIOPT Version :9

Sequence 1:	NP_001286048.1	Gene:	CG10413 / 35111	FlyBaseID:	FBgn0032689	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_001255279.2	Gene:	kcc-2 / 177370	WormBaseID:	WBGene00019205	Length:	1129	Species:	Caenorhabditis elegans

Alignment Length:	1118	Identity:	251/1118 - (22%)
Similarity:	439/1118 - (39%)	Gaps:	279/1118 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 QETAPIA------NSRSGRTGSVFRSFGSLFGGSQNSGDRPHTPQDGDGYVEFGMQDPDRSGRTL 65
            ::.:|:|      :::..:.|::.|.. |::..::      .|..:.|       :.|..:...:
Worm   103 EQHSPLALYEQDYDTQGQKIGTMLRKL-SVYNATE------ATSVEAD-------EKPKAAAAKM 153

  Fly    66 GTFAGVFSPVALSMFSALVFIRVGYIVGNAGLYVTLLQFLIAYGILLFTVASVCAISTNGAIEGG 130
            ||..|||.|...::|..|.|||:.:|:|.||::......|....:...|..|:.||:|||.:..|
Worm   154 GTIMGVFLPCLQNIFGVLFFIRLAWIIGTAGVFQAFFVVLTCVSVTFLTSISLSAIATNGVVPSG 218

  Fly   131 GVYFMISRTLGLEFGGSIGTLFFFANVVGSAMAISGCTEGIMDNFGPRGHFVSGDSHLPDGDWWR 195
            |.|:||||.||.|.||::|.||:....:.::|.|:|..|.::....|:........|.     :|
Worm   219 GPYYMISRNLGPELGGAVGILFYLGTTIAASMYITGAIEILLLYIYPQAKLFDDIYHN-----FR 278

  Fly   196 FLTSSMINTLQLLVCLVGAALFAKTSVIILATVTVCLFATYFSFLFV---GATNNTIPVPGDNIL 257
            .|.:.::..|.|:| :.|.....:.::.::..|.:|:.:.... :||   |:.:....:.||..:
Worm   279 VLGTVLLLILGLIV-MAGVKFVNRCALPLVIVVILCILSAILG-VFVRYDGSDSLKFCMVGDRPV 341

  Fly   258 SNTTTF------------------------LDY-------------------------TGLNATT 273
            ..:|.|                        .|:                         .|:.:..
Worm   342 DLSTYFEKTQVQPNCTADGLQDLFCSTNGTCDHYYDRMKNIKVWKSSGMPAIREERAIKGIASGV 406

  Fly   274 LRDNLGSHYGR-------------DYTSNG--------KQVDFSTTFGVLFSGVTGIMAGANMSG 317
            ..|||...|.|             |....|        ...:|....||.|...||||||:|.||
Worm   407 FFDNLWPKYLRAGEVLSKDRKDKGDLNRGGHPSYIYAESVTNFMILVGVFFPSATGIMAGSNRSG 471

  Fly   318 ELKNPSKSIPYGTLSAVAFTFVSYIILSFLMSCTTPYFTMQNNY-------LFLMPVNLWPPFTA 375
            .|::.:||||.|||:|..|:...|::...|...:.....:::.|       |.:..:: | ||..
Worm   472 NLRDAAKSIPLGTLAAQNFSSFIYLLGVVLFGASVSEMFIRDKYGRSAMGKLIISEIS-W-PFPQ 534

  Fly   376 I---GILTATFSTSLSNLIGSSRILEALSKDQVFGSLLNFVIHGTWKGNPIAAVAVSWCLVECIL 437
            :   |...:|....:.:|.|:.|:|:|::.|.|...|..|....: :|.||.|:.::..:.||.:
Worm   535 VILFGCFMSTAGAGMQSLTGAPRLLQAIAADDVLPFLKPFRKMDS-RGEPIRAILLTLAICECGI 598

  Fly   438 LIGSFNIIAQINSVLFMLSYLATNLACLGIELTGAPNFRPLFKFFTWHTCLVGLLGTLIMMFVIN 502
            ||.....|..:.:..|::.||..|.||....|..:|.:||.|::|.|...::|.:..:.:||:..
Worm   599 LIAVIENITALITQFFLMCYLGVNAACALQSLLKSPGWRPGFRYFHWSLSMIGAILCVAVMFISA 663

  Fly   503 FIYASSCIILCLILVIALHLF-SPATQAAQWGSISQALMFHQVRKYLLMLDPRKDHVKFWRPQIL 566
            :.:|    :..:|:...::.: ..|....:||...:.|.....|..||.||.:..|.:.||||:|
Worm   664 WHFA----LFAIIIGAGVYKYIEYAGAEKEWGDGLRGLGLSAARFALLNLDDKPQHSRNWRPQLL 724

  Fly   567 LLVSSPRSCCP--LVDFVNDLKK-SGLYIIGHVKLGDFKGIEDAEDN--------QQWWSFLDHM 620
            :|.....|...  ::.||:.||. .||.::.|...|::      .||        ::..:.:...
Worm   725 VLAPDVESANTNGILSFVSQLKAGKGLTLVAHCMEGEY------ADNYLKAQAVQEKLKAVVKKN 783

  Fly   621 RVKAFTEVTLSRSIREGVQHLIRLSGIGAMKPNTIILGFYDSEAPRDFFQNGSSPYKTDDFNNGE 685
            ::|.|.:|.::.::.||:..|::.||:|.|:.||::|.:     |.|:
Worm   784 KIKGFCDVLVTSNVIEGISCLVQTSGLGGMRHNTVVLSW-----PNDW----------------- 826

  Fly   686 IQNFPIRRDGDPKQFQIQEYVQILCDTLRMKKNLCLCRNFQRLDKNFISMSKHVKYIDVWPINIF 750
                    ..:.:.....::|..:......|..:.:.:..::...|...:|   .:||||.:
Worm   827 --------KAEQEWVVANKFVSAIRAISAAKCAIMVPKYAEKFPANGTKVS---GFIDVWWV--- 877

  Fly   751 NPTSGDPFDMVSLFMMQLAVIMLAKWKHLRVRIFLCEANDERTVGTFDTQTPQMEIFSKMKLEQS 815
                  ..|...|.::...:.....||:..||:|.....::..|        ||    |..||:.
Worm   878 ------VHDGGLLMLLPFLLRQHKTWKNTTVRLFAIAQMEDNNV--------QM----KTDLEKF 924

  Fly   816 LKELRITA--DIVE--------------------------IQEWSRDTDFSRH------ARTLKQ 846
            |..|||.|  :::|                          :.:..||.|...|      .|.|.:
Worm   925 LYHLRIDAAVNVIEMTDSDISDYTYERTMKMEERNQYLKNLNKSDRDKDIQNHLEIVTRERKLSR 989

  Fly   847 FTAQADNVVLE------------------------------DDDE------VGEETLNRSLLYMQ 875
            ...:|..||.|                              .|||      ||..||.|.....|
Worm   990 INEEAPAVVPEQRNLEVVDEEQEDGKSENGSAKIEHKGVRFSDDEDSKEVKVGNGTLERDREERQ 1054

  Fly   876 R--------------ANQIIRERSDQTALSFIYLAAPPKLSAPDFAQRSASYMELLTELTADLPP 926
            |              .|:::|::|....|.|:.|..||.      |...:.||:.:..||..|..
Worm  1055 RKRRYNVHKMHTAVKLNELMRQKSSDAQLVFVNLPGPPD------ADSDSYYMDFIEALTEGLDR 1113

  Fly   927 TILVHGVSTVTST 939
            .:||.|......|
Worm  1114 VLLVRGTGAEVVT 1126

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10413	NP_001286048.1	2a30	22..932	CDD:273347	246/1088 (23%)
CG10413	NP_001286048.1	SLC12	577..932	CDD:281515	88/449 (20%)
kcc-2	NP_001255279.2	2a30	144..1129	CDD:273347	244/1063 (23%)
kcc-2	NP_001255279.2	SLC12	741..1129	CDD:281515	90/452 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910