DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10413 and Slc12a9

DIOPT Version :9

Sequence 1:	NP_001286048.1	Gene:	CG10413 / 35111	FlyBaseID:	FBgn0032689	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_599232.2	Gene:	Slc12a9 / 171443	RGDID:	620747	Length:	914	Species:	Rattus norvegicus

Alignment Length:	984	Identity:	403/984 - (40%)
Similarity:	543/984 - (55%)	Gaps:	123/984 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ETAPIANSR-SGRTGSVFRSFGSLFGGSQNSGDRPHTPQDGDGYVEFGMQDPDRSGRTLGTFAGV 71
            |.:|:...| .|..|:.|...|:  |||                   |:    .|.|.|.||.||
  Rat     4 ENSPLLAYRLLGEEGAAFPPNGA--GGS-------------------GV----ASARKLSTFLGV 43

  Fly    72 FSPVALSMFSALVFIRVGYIVGNAGLYVTLLQFLIAYGILLFTVASVCAISTNGAIEGGGVYFMI 136
            ..|..|||||.:||:|:|::||:|||...|...|:||.||..||.|||||:||||:.|||.||||
  Rat    44 VVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYVILALTVLSVCAIATNGAVRGGGAYFMI 108

  Fly   137 SRTLGLEFGGSIGTLFFFANVVGSAMAISGCTEGIMDNFGPRGHFVSGDSHLPDGDWWRFLTSSM 201
            |||||.|.|||||.:|:.|||.|.|:::.|..|.|:|.||......||...||.|..|..|..|:
  Rat   109 SRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESILDVFGADVTGSSGIKVLPQGYGWNLLYGSL 173

  Fly   202 INTLQLLVCLVGAALFAKTSVIILATVTVCLFATYFSFLFVGATNNTI-PVPGDNILSNTTTFLD 265
            :..|...||.:||.|:|:.|.:....|:..|.:...||:.||..|.|: |.||.|..|.......
  Rat   174 LLGLVGGVCALGAGLYARASFLTFLLVSGSLASVLVSFVAVGPRNITLAPRPGTNGSSVPPRHGH 238

  Fly   266 YTGLNATTLRDNLGSHYGRDYTSNGKQVDFSTTFGVLFSGVTGIMAGANMSGELKNPSKSIPYGT 330
            :||.|.:||:||||:.|..|||: |..:.|::.|.|||:|.||||||||||||||:||::||.||
  Rat   239 FTGFNGSTLKDNLGAGYAEDYTT-GAMMTFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGT 302

  Fly   331 LSAVAFTFVSYIILSFLMSCTTPYFTMQNNYLFLMPVNLWPPFTAIGILTATFSTSLSNLIGSSR 395
            :.|||:||..||:|.||.|.|.....:|.:|.|...::||||...|||.....|.|:|:|||:||
  Rat   303 IIAVAYTFFIYILLFFLSSFTCDRALLQGDYGFFRDISLWPPLVLIGIYATALSASMSSLIGASR 367

  Fly   396 ILEALSKDQVFGSLL--NFVIHGTWKGNPIAAVAVSWCLVECILLIGSFNIIAQINSVLFMLSYL 458
            ||.||::|.:||.:|  ..|:.|  .|||..||..||.||:.:||.|..|.:|.:.:|.::::|.
  Rat   368 ILHALAQDDLFGVILAPAKVVSG--GGNPWGAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYA 430

  Fly   459 ATNLACLGIELTGAPNFRPLFKFFTWHTCLVGLLGTLIMMFVINFIYASSCIILCLILVIALHLF 523
            |.:|:||.:|...||||||.|..|:|||||:|:...|:|||:|:...|...::|..:|..   |.
  Rat   431 AVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGAAGGSLLLMGLLSA---LL 492

  Fly   524 SPATQAAQWGSISQALMFHQVRKYLLMLDPRKDHVKFWRPQILLLVSSPRSCCPLVDFVNDLKKS 588
            :.....:.||.:||||:|||||||||.||.||:||||||||:||||.:||...||:...|.|||.
  Rat   493 TARGGPSSWGYVSQALLFHQVRKYLLRLDVRKEHVKFWRPQLLLLVGNPRGALPLLRLANQLKKG 557

  Fly   589 GLYIIGHVKLGDFKGIEDAEDNQQ---WWSFLDHMRVKAFTEVTLSRSIREGVQHLIRLSGIGAM 650
            |||::|||.|||...:.......|   |.|.:|..:||||.::|||.|:|:|.|||:|:||:|.|
  Rat   558 GLYVLGHVTLGDLDSLPSDPVQPQYGAWLSLVDLAQVKAFVDLTLSPSVRQGAQHLLRISGLGGM 622

  Fly   651 KPNTIILGFYDSEAPRDFF-------------QNGSSPYKTDDFNNGEIQNFPIRRDGDPKQFQI 702
            ||||::|||||...|:|.|             :.|.||..:..|.       |.|..|.|:....
  Rat   623 KPNTLVLGFYDDAPPQDHFLTDPAFSEPAEGTREGGSPALSTLFP-------PPRAPGSPRALSP 680

  Fly   703 QEYVQILCDTLRMKKNLCLCRNFQRLDKNFIS----MSKHVKYIDVWPINIFNPTSGDPF-DMVS 762
            |:||..:.|.|:|.||:.|.|....|....:|    .|..:.::||||:|:..|..|..: |:..
  Rat   681 QDYVATVADALKMNKNVVLARACGALPPERLSRGSGSSAQLHHVDVWPLNLLRPRGGPGYVDVCG 745

  Fly   763 LFMMQLAVI--MLAKWKHLRVRIFLCEANDERTVGTFDTQTPQMEIFSKMKLEQSLKELRITADI 825
            ||::|:|.|  |:..|...|:|||||....|....            ::.:|...|.:|||.|::
  Rat   746 LFLLQMATILSMVPAWHSARLRIFLCLGPREAPGA------------AEGRLRALLSQLRIRAEV 798

  Fly   826 VEIQEWSRDTDFSRHARTLKQFTAQADNVVLEDDDEV----GEETLNRSLLYMQRANQIIR---- 882
            .|: .|...              |:|.....|:.|.|    |:|.......   .||.::|
  Rat   799 QEV-VWGEG--------------AEAGEPEEEEGDFVNGGRGDEEAEALAC---SANALVRAQQG 845

  Fly   883 ---------------ERSDQTALSFIYLAAPPKLSAPDFAQRSASYMELLTELTADLPPTILVHG 932
                           |....|||:|:||..||...|     |...|:.||..|:.||.||:|:||
  Rat   846 RGTGGGPGGPEGRDGEEGPTTALTFLYLPRPPADPA-----RYPRYLALLETLSRDLGPTLLIHG 905

  Fly   933 VSTVTSTTL 941
            |:.||.|.|
  Rat   906 VTPVTCTDL 914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10413	NP_001286048.1	2a30	22..932	CDD:273347	391/958 (41%)
CG10413	NP_001286048.1	SLC12	577..932	CDD:281515	130/400 (33%)
Slc12a9	NP_599232.2	2a30	36..905	CDD:273347	383/916 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	645..678		8/39 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	843..864		1/20 (5%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	447	1.000	Domainoid score	I501
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5429
Inparanoid	1	1.050	653	1.000	Inparanoid score	I747
OMA	1	1.010	-	-		QHG48944
OrthoDB	1	1.010	-	-		D310826at33208
OrthoFinder	1	1.000	-	-		FOG0004225
OrthoInspector	1	1.000	-	-		oto97340
orthoMCL	1	0.900	-	-		OOG6_104998
Panther	1	1.100	-	-	LDO	PTHR11827
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2970
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.980