Protein Alignment CG10413 and Slc12a5

DIOPT Version :10

• Sequence 1: NP_609887.1
• Gene: CG10413 / 35111
• FlyBaseID: FBgn0032689
• Length: 941
• Species: Drosophila melanogaster
• Sequence 2: NP_001380604.1
• Gene: Slc12a5 / 171373
• RGDID: 620811
• Length: 1139
• Species: Rattus norvegicus
• Alignment Length: 1187
• Identity: 291/1187 - (24%)
• Similarity: 466/1187 - (39%)
• Gaps: 348/1187 - (29%)

  Fly     7 QETAPIANSR--------SGRTGSVFRS-------FGSLFGGSQN-----SGDRPHTPQDGDGYV 51
            :|::|..||.        .||..::|..       ..||..|..|     .|.:.|...:.:
  Rat    46 KESSPFINSTDTEKGREYDGRNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSKEHEEAENN--- 107

  Fly    52 EFGMQDPDRSGRTLGTFAGVFSPVALSMFSALVFIRVGYIVGNAGLYVTLLQFLIAYGILLFTVA 116
            |.|.:.|.::.| :|||.||:.|...::|..::|:|:.::||.||:..:.....|.....:.|..
  Rat   108 EGGKKKPVQAPR-MGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAI 171

  Fly   117 SVCAISTNGAIEGGGVYFMISRTLGLEFGGSIGTLFFFANVVGSAMAISGCTEGIMDNFGP---- 177
            |:.||:|||.:..||.|:||||:||.||||::|..|:.......||.|.|..|.::....|
  Rat   172 SMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAI 236

  Fly   178 -RGHFVSGDSHLPDGDWWRFLTSSMINTLQ-----LLVCL-----VGAALFAKTSVIILATVTVC 231
             :....||::            ::|:|.::     :|.|:     ||.....|.:::.|..|.:.
  Rat   237 FKAEDASGEA------------AAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILS 289

  Fly   232 LFATY------------FSFLFVGATNNTIPVPGDNILS--------NTTT-----FLDYTGLNA 271
            :.|.|            |....:|  |.|:...|.::.:        ..||     |.....|||
  Rat   290 ILAIYAGVIKSAFDPPNFPICLLG--NRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRLLNA 352

  Fly   272 T----------------------TLRDNLGSHY--------GRDYTS----NGKQVD-------- 294
            |                      .:::||.|.|        .|...|    :|..||
  Rat   353 TCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERRGMPSVGLADGTPVDMDHPYVFS 417

  Fly   295 -----FSTTFGVLFSGVTGIMAGANMSGELKNPSKSIPYGTLSAVAFTFVSYIILSFLMSCTTPY 354
                 |:...|:.|..|||||||:|.||:|::..||||.||:.|:|.|...||....|.......
  Rat   418 DMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEG 482

  Fly   355 FTMQNNYLFLMPVNL------WP-PFT-AIGILTATFSTSLSNLIGSSRILEALSKD------QV 405
            ..:::.:...:..||      || |:. .||...:|....|.:|.|:.|:|:|:|:|      ||
  Rat   483 VVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQV 547

  Fly   406 FGSLLNFVIHGTWKGNPIAAVAVSWCLVECILLIGSFNIIAQINSVLFMLSYLATNLACLGIELT 470
            ||       ||...|.|..|:.::.|:.|..:||.|.:.:|.|.|:.|::.|:..||||....|.
  Rat   548 FG-------HGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLL 605

  Fly   471 GAPNFRPLFKFFTWHTCLVGLLGTLIMMFVINFIYASSCIILCLILVIALHLFSPATQAAQWGSI 535
            ..||:||.|:::.|....:|:...|.:||:.::.||   ::..||..:............:||..
  Rat   606 RTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYA---LVAMLIAGLIYKYIEYRGAEKEWGDG 667

  Fly   536 SQALMFHQVRKYLLMLDPRKDHVKFWRPQILLLVS--------SPRSCCPLVDFVNDLKK-SGLY 591
            .:.|.....|..||.|:....|.|.||||:|:||.        .|:    |:...:.||. .||.
  Rat   668 IRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQ----LLSLTSQLKAGKGLT 728

  Fly   592 IIGHVKLGDF----KGIEDAEDNQQWWSFLDHMRVKAFTEVTLSRSIREGVQHLIRLSGIGAMKP 652
            |:|.|..|.|    ...:.||::.:  ..::..:||.|.:|.:|.::|:||.|||:..|:|.::.
  Rat   729 IVGSVLEGTFLDNHPQAQRAEESIR--RLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQH 791

  Fly   653 NTIILGFYDSEAPRDFFQNGSSPYKTDDFNNGEIQNFPIRRDGDPKQFQIQEYVQILCDTLRMKK 717
            ||:::|:     ||::                       |:..|.:.:  :.:::::.:|.....
  Rat   792 NTVLVGW-----PRNW-----------------------RQKEDHQTW--RNFIELVRETTAGHL 826

  Fly   718 NLCLCRNFQRLDKNFISMSKHVKYIDVWPINIFNPTSGDPFDMVSLFMMQLAVIMLAKWKHLRVR 782
            .|.:.:|......|....|:  ..||||.|         ..|...|.::...:.....|:..::|
  Rat   827 ALLVTKNVSMFPGNPERFSE--GSIDVWWI---------VHDGGMLMLLPFLLRHHKVWRKCKMR 880

  Fly   783 IFLCEANDERTVGTFDTQTPQMEIFSKMKLEQSLKELRITA--DIVEIQE-------WSRDTDFS 838
            ||        ||...|..:.||    |..|...|..|||||  ::||:.|       :.:.....
  Rat   881 IF--------TVAQMDDNSIQM----KKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVME 933

  Fly   839 RHARTLKQF---------------------------------------TAQADN-------VVL- 856
            :.::.|||.                                       || .||       |.|
  Rat   934 QRSQILKQMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETA-CDNEEKPEEEVQLI 997

  Fly   857 ----------------EDDDEVGE----------------------------------------- 864
                            |:.:..||
  Rat   998 HDQSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSAAQKNKGPSPVSSEGIKDFFSMKPEW 1062

  Fly   865 ETLNRSLLYMQ----RANQIIRERSDQTALSFIYLAAPPKLSAPDFAQRSASYMELLTELTADLP 925
            |.||:|.:...    |.|::|..:|....|..:.:..||:....|     .:|||.|..||..|.
  Rat  1063 ENLNQSNVRRMHTAVRLNEVIVNKSRDAKLVLLNMPGPPRNRNGD-----ENYMEFLEVLTEQLD 1122

  Fly   926 PTILVHG----VSTVTS 938
            ..:||.|    |.|:.|
  Rat  1123 RVMLVRGGGREVITIYS 1139

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10413	NP_609887.1	AA_permease_2	22..932	CDD:459263	281/1152 (24%)
Slc12a5	NP_001380604.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..62		4/15 (27%)
		2a30	44..1139	CDD:273347	290/1185 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	95..116		5/23 (22%)
		Scissor helix. /evidence=ECO:0000250|UniProtKB:Q9H2X9	667..681		2/13 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	943..1025		9/82 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1033..1052		0/18 (0%)