Protein Alignment CG10413 and SLC12A7

DIOPT Version :9

• Sequence 1: NP_001286048.1
• Gene: CG10413 / 35111
• FlyBaseID: FBgn0032689
• Length: 941
• Species: Drosophila melanogaster
• Sequence 2: XP_011512243.2
• Gene: SLC12A7 / 10723
• HGNCID: 10915
• Length: 1111
• Species: Homo sapiens
• Alignment Length: 1076
• Identity: 268/1076 - (24%)
• Similarity: 427/1076 - (39%)
• Gaps: 271/1076 - (25%)

  Fly    49 GYVEFGMQDPDRSGR------TLGTFAGVFSPVALSMFSALVFIRVGYIVGNAGLYVTLLQFLIA 107
            |.||.  ::.:.|.|      .:|||.||:.|...::...::|:|:.:|||.||:..:.|...:.
Human   121 GVVEH--EEDEESRRREAKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAMC 183

  Fly   108 YGILLFTVASVCAISTNGAIEGGGVYFMISRTLGLEFGGSIGTLFFFANVVGSAMAISGCTEGIM 172
            ....:.|..|:.||:|||.:..||.|:||||:||.||||::|..|:.......||.|.|..|..:
Human   184 CTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFL 248

  Fly   173 DNFGPRGHFVSGDSHLPDGDWWRFLTSSMINTLQL----------LVCLVGAALFAKTSVIILAT 227
            ....|.......::  ..|:     .::|::.:::          ||..||.....|.:::.||.
Human   249 TYISPGAAIFQAEA--AGGE-----AAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALVFLAC 306

  Fly   228 VTVCLFATYFSFLFVGATNNTIPV--PGDNILS-------------------------------- 258
            |.:.:.|.|...:........|||  .|:..||
Human   307 VVLSILAIYAGVIKSAFDPPDIPVCLLGNRTLSRRSFDACVKAYGIHNNSATSALWGLFCNGSQP 371

  Fly   259 -----------NTTTFLDYTGLNATTLRDNLGSHYGR------------------------DYTS 288
                       |.|......|..:....:||.|.|..                        .|..
Human   372 SAACDEYFIQNNVTEIQGIPGAASGVFLENLWSTYAHAGAFVEKKGVPSVPVAEESRASALPYVL 436

  Fly   289 NGKQVDFSTTFGVLFSGVTGIMAGANMSGELKNPSKSIPYGTLSAVAFTFVSYIILSFLMSCTTP 353
            ......|:...|:.|..|||||||:|.||:||:..||||.||:.|:..|...|:....|......
Human   437 TDIAASFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIE 501

  Fly   354 YFTMQNNYLFLMPVNL------WP-PFT-AIGILTATFSTSLSNLIGSSRILEALSKD------Q 404
            ...:::.:...:..||      || |:. .||...:|....|.:|.|:.|:|:|:::|      |
Human   502 GVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQ 566

  Fly   405 VFGSLLNFVIHGTWKGNPIAAVAVSWCLVECILLIGSFNIIAQINSVLFMLSYLATNLACLGIEL 469
            |||       ||...|.|..|:.::..:.|..:||.|.:.:|.|.|:.|::.||..||||....|
Human   567 VFG-------HGKANGEPTWALLLTVLICETGILIASLDSVAPILSMFFLMCYLFVNLACAVQTL 624

  Fly   470 TGAPNFRPLFKFFTWHTCLVGLLGTLIMMFVINFIYASSCIIL--CLILVIALHLFSPATQAAQW 532
            ...||:||.|||:.|....:|:...|.:||:.::.||.|.:::  |:...|.   :..|.:  :|
Human   625 LRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYIE---YRGAEK--EW 684

  Fly   533 GSISQALMFHQVRKYLLMLDPRKDHVKFWRPQILLL--------VSSPRSCCPLVDFVNDLKK-S 588
            |...:.|..:..|..||.::....|.|.||||:|::        |..||    |:.|.:.||. .
Human   685 GDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDAEQAVKHPR----LLSFTSQLKAGK 745

  Fly   589 GLYIIGHVKLGDF--KGIE--DAEDNQQWWSFLDHMRVKAFTEVTLSRSIREGVQHLIRLSGIGA 649
            ||.|:|.|..|.:  |.:|  .||:|.:  |.:...:.|.|.::.:|.|:|:|:.|||:.:|:|.
Human   746 GLTIVGSVLEGTYLDKHMEAQRAEENIR--SLMSTEKTKGFCQLVVSSSLRDGMSHLIQSAGLGG 808

  Fly   650 MKPNTIILGFYDSEAPRDFFQNGSSPYKTDDFNNGEIQNFPIRRDGDPKQFQIQEYVQILCDTLR 714
            :|.||:::.:             .:.:|.:|                 ..|..:.:|..:.||..
Human   809 LKHNTVLMAW-------------PASWKQED-----------------NPFSWKNFVDTVRDTTA 843

  Fly   715 MKKNLCLCRNFQRLDKNFISMSKHVKYIDVWPINIFNPTSGDPFDMVSLFMMQLAVIMLAKWKHL 779
            ..:.|.:.:|.....:|......  .:||||.|    ...|....::...:.|..|     |:..
Human   844 AHQALLVAKNVDSFPQNQERFGG--GHIDVWWI----VHDGGMLMLLPFLLRQHKV-----WRKC 897

  Fly   780 RVRIFLCEANDERTVGTFDTQTPQMEIFSKMKLEQSLKELRITA--DIVEIQE-------WSRDT 835
            |:|||        ||...|..:.||    |..|:..|..|||:|  ::||:.|       :.|..
Human   898 RMRIF--------TVAQVDDNSIQM----KKDLQMFLYHLRISAEVEVVEMVENDISAFTYERTL 950

  Fly   836 DFSRHARTLKQF----------------------TAQADNVVLEDDDEVGEETLNRSLLYMQ--- 875
            ...:.::.|||.                      ||.|.........:..:.|..|..|..:
Human   951 MMEQRSQMLKQMQLSKNEQEREAQLIHDRNTASHTAAAARTQAPPTPDKVQMTWTREKLIAEKYR 1015

  Fly   876 ----------------------------------RANQIIRERSDQTALSFIYLAAPPKLSAPDF 906
                                              :.|.::..:|....|..:.:..|||     .
Human  1016 SRDTSLSGFKDLFSMKPEWGNLDQSNVRRMHTAVKLNGVVLNKSQDAQLVLLNMPGPPK-----N 1075

  Fly   907 AQRSASYMELLTELTADLPPTILVHG----VSTVTS 938
            .|...:|||.|..||..|...:||.|    |.|:.|
Human  1076 RQGDENYMEFLEVLTEGLNRVLLVRGGGREVITIYS 1111

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10413	NP_001286048.1	2a30	22..932	CDD:273347	264/1064 (25%)
		SLC12	577..932	CDD:281515	93/427 (22%)
SLC12A7	XP_011512243.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158240
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840