Protein Alignment CG10413 and slc12a6

DIOPT Version :10

• Sequence 1: NP_609887.1
• Gene: CG10413 / 35111
• FlyBaseID: FBgn0032689
• Length: 941
• Species: Drosophila melanogaster
• Sequence 2: XP_073763941.1
• Gene: slc12a6 / 100330290
• ZFINID: ZDB-GENE-160113-148
• Length: 1165
• Species: Danio rerio
• Alignment Length: 1220
• Identity: 300/1220 - (24%)
• Similarity: 468/1220 - (38%)
• Gaps: 374/1220 - (30%)

  Fly     8 ETAPIANSRSG---RTGSVFRSFGSLFGGSQNSGDRPHTP----QDGDGYVEF---------GMQ 56
            :|:|..::||.   |.||  |...|...|:.|:.....||    :.|||.|:.         .|.
Zfish    31 DTSPDISARSNARVRFGS--RESVSEASGAFNTSTGAETPDRSHEQGDGGVKLSSVYINNSHAMD 93

  Fly    57 DPDRSGRTL---------------------------------------------------GTFAG 70
            |.|...|.|                                                   |||.|
Zfish    94 DDDFYDRNLALFEEEMDTRPKVSSLLNRLANYTNLTQGAKEHEEAESIGEKRKPSKSPQMGTFMG 158

  Fly    71 VFSPVALSMFSALVFIRVGYIVGNAGLYVTLLQFLIAYGILLFTVASVCAISTNGAIEGGGVYFM 135
            |:.|...::|..::|:|:.::||.||:...|....|.....|.|..|:.||:|||.:..||.|||
Zfish   159 VYLPCLQNIFGVILFLRLTWVVGTAGVLQALCIVFICCCCTLLTAISMSAIATNGVVPAGGSYFM 223

  Fly   136 ISRTLGLEFGGSIGTLFFFANVVGSAMAISGCTEGIMDNFGPRGHFVSGDSHLPDGDWWRFLTSS 200
            |||:||.||||::|:.|:.......:|.|.|..|.::....|.......|:  |||:     .::
Zfish   224 ISRSLGPEFGGAVGSCFYLGTTFAGSMYILGAIEILLMYIAPGAAIFVSDT--PDGE-----AAA 281

  Fly   201 MINTLQL----------LVCLVGAALFAKTSVIILATVTVCLFATYFSFLFVGATNNTIPV---- 251
            |:|.:::          |:..||.....|.:.:.||.|.:.:.:.|...|....:..:.||
Zfish   282 MLNNMRVYGSIFLLLMSLLVFVGVKYVNKLASVFLACVIISILSIYTGALVSAFSPPSFPVCMLG 346

  Fly   252 ----------------------PGDNI-----------------LSNTT---------------- 261
                                  |.|::                 |..||
Zfish   347 NMSLSQHELKDSQCVKTLREVLPQDSVNGSELFNSTAAPPSVAPLEKTTDVWRLFCNSSELSAAC 411

  Fly   262 ----TFLDYT------GLNATTLRDNLGSHY---------GRDYTSNGKQV---------DFSTT 298
                |..:.|      ||.:..:::||.|.|         |..::::...|         |.:|:
Zfish   412 DEHFTHNELTQIQGIPGLASGVIKENLWSSYSAKGDVLERGSSHSAHKPAVSNHYPYVFADITTS 476

  Fly   299 F----GVLFSGVTGIMAGANMSGELKNPSKSIPYGTLSAVAFTFVSYIILSFLMSCTTPYFTMQN 359
            |    |:.|..|||||||:|.||:||:..:|||.||:.|:..|.:.|:....|.........:::
Zfish   477 FTLLVGIFFPSVTGIMAGSNRSGDLKDAQRSIPIGTIMAILTTSLVYLSCVLLFGACVEGVVLRD 541

  Fly   360 -------NYLFLMPVNLWP-PFT-AIGILTATFSTSLSNLIGSSRILEALSKD------QVFGSL 409
                   .||.:..:: || |:. .||...:|....|.:|.|:.|:|:|::||      :|||
Zfish   542 KFGDSVKGYLVVGTLS-WPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFG-- 603

  Fly   410 LNFVIHGTWKGNPIAAVAVSWCLVECILLIGSFNIIAQINSVLFMLSYLATNLACLGIELTGAPN 474
                 ||...|.|..|:.::..|.|..:||.|.:::|.|.|:.|::.||..||||....|...||
Zfish   604 -----HGKANGEPTWALLLTALLAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPN 663

  Fly   475 FRPLFKFFTWHTCLVGLLGTLIMMFVINFIYASSCIILCLILVIALHLFSPATQA-AQWGSISQA 538
            :||.|.::.|....:|:...|.:||:.::.||    |:.:::...::.:.....| .:||...:.
Zfish   664 WRPRFSYYHWTLSFLGMTICLALMFISSWYYA----IVAMVIAGMIYKYIEYHGAEKEWGDGIRG 724

  Fly   539 LMFHQVRKYLLMLDPRKDHVKFWRPQILLL--------VSSPRSCCPLVDFVNDLKK-SGLYIIG 594
            |.....|..||.|:....|.|.||||:|:|        |.|||    |:.|.:.||. .||.|:|
Zfish   725 LSLSAARFALLRLEEGPPHTKNWRPQLLVLVKLDEDAHVKSPR----LLTFASQLKAGKGLTIVG 785

  Fly   595 HVKLGDFKGI--EDAEDNQQWWSFLDHMRVKAFTEVTLSRSIREGVQHLIRLSGIGAMKPNTIIL 657
            .|..|:|...  |.....|.....::..|||.|.:..:::..|||:.|:|:.||:|.||.||:::
Zfish   786 TVIPGNFLHTYGEALAAEQTLKHLMEKERVKGFVQCIVAQKPREGISHMIQSSGLGGMKHNTVVM 850

  Fly   658 GFYDSEAPRDFFQNGSSPYKTDDFNNGEIQNFPIRRDGDPKQFQIQEYVQILCDTLRMKKNLCLC 722
            |:               |:..             |:..||:.:  :.::..:..|......|.:.
Zfish   851 GW---------------PHAW-------------RQSEDPQSW--KTFINTVRVTTTAHLALLVL 885

  Fly   723 RNFQRLDKNFISMSKHVKYIDVWPINIFNPTSGDPFDMVSLFMMQLAVIMLAKWKHLRVRIFLCE 787
            :|......|..:.::  .:||:|.|    ...|....::...:.|..|     |:...:|||
Zfish   886 KNISLFPSNSEACTE--GFIDIWWI----VHDGGMLMLLPFLLRQHKV-----WRKCALRIF--- 936

  Fly   788 ANDERTVGTFDTQTPQMEIFSKMKLEQSLKELRITADIVEIQEWSRDTDFSRHA--RTL-----K 845
                 ||...:..:.||    |..|...|..|||.| .||:.| ..|:|.|.:.  |||     .
Zfish   937 -----TVAQMEDNSIQM----KKDLATFLYHLRIDA-AVEVVE-MHDSDISAYTYERTLMMEQRS 990

  Fly   846 QFTAQA----------------DNVVL--------------EDDDEVGE---------------- 864
            |...|.                |:..|              .||||..|
Zfish   991 QMLRQMRLSKSDREKERVRWSFDDAQLVKDRNSMLHLTSIGSDDDEDTEGLSAADKSAEHRRVHM 1055

  Fly   865 -----------------------------ETLN--------RSLLYMQRANQIIRERSDQTALSF 892
                                         :.||        |.:....:.|::|..:|....|..
Zfish  1056 TWTKDKALQLRSNTHTHTQSCCSTPEGFRDMLNIRPDHSNVRRMHTAVKLNEVIVNKSHDARLVL 1120

  Fly   893 IYLAAPPKLSAPDFAQRSASYMELLTELTADLPPTILVHG----VSTVTS 938
            :.:..|||  .||   ...:|||.|..||..|...:||.|    |.|:.|
Zfish  1121 LNMPGPPK--NPD---GDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1165

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10413	NP_609887.1	AA_permease_2	22..932	CDD:459263	290/1191 (24%)
slc12a6	XP_073763941.1	None