Protein Alignment CG10413 and slc12a1

DIOPT Version :9

• Sequence 1: NP_001286048.1
• Gene: CG10413 / 35111
• FlyBaseID: FBgn0032689
• Length: 941
• Species: Drosophila melanogaster
• Sequence 2: XP_021323409.1
• Gene: slc12a1 / 100329975
• ZFINID: ZDB-GENE-080130-3
• Length: 1037
• Species: Danio rerio
• Alignment Length: 1073
• Identity: 271/1073 - (25%)
• Similarity: 459/1073 - (42%)
• Gaps: 233/1073 - (21%)

  Fly     7 QETAPIANSRSGRTG-----SVFRSFGSLFGGSQNSGDRPHTPQDGDGY-------VE--FGMQD 57
            :..|.|:..|:.|..     .||:..|.|        :.|...:|.:|.       ||  ..:::
Zfish    57 RNAASISGHRAVRPSLHELHDVFQKNGGL--------NLPSPVEDSEGVDSSTLGDVESVTPLEE 113

  Fly    58 PDRSGRT-LGTFAGVFSPVALSMFSALVFIRVGYIVGNAGLYVTLLQFLIAYGILLFTVASVCAI 121
            .|..|.. .|...||.....|:::..::|||:.::.|.||:.:.::..|::..:...|..|:.||
Zfish   114 KDTGGVVKFGWIKGVLVRCMLNIWGVMLFIRLSWVFGQAGIGLGIVVVLLSMVVTSVTCLSMSAI 178

  Fly   122 STNGAIEGGGVYFMISRTLGLEFGGSIGTLFFFANVVGSAMAISGCTEGIMDNFGPRGHFVSGDS 186
            .|||.:.|||.|::|||:||.|||||||.:|.|||.|..||.:.|..|.:::        :..||
Zfish   179 CTNGVVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVE--------LLKDS 235

  Fly   187 HLPDGDWWRFLTSSMINTLQLLVCLVGAALF----------AKTSVIILATVTVCLFATYFSFLF 241
            :.        |.....|.::::.|:....|.          ||..|.:|..:.|.:     :.:|
Zfish   236 NA--------LIVDPTNDIRIIGCITVVLLMGITVAGMEWEAKAQVALLVILLVAI-----ANVF 287

  Fly   242 VGATNNTIPVPGDNILSNTTTFLDYTGLNATTLRDNLGSHYGRDYTSNGKQVDFSTTFGVLFSGV 306
            ||   ..||...|   ..:..|.:|   :.:..::|....: ||..:      |.:.|.:.|...
Zfish   288 VG---TVIPSTQD---KRSKGFFNY---HESIAKENFIPDF-RDGET------FFSVFAIFFPAA 336

  Fly   307 TGIMAGANMSGELKNPSKSIPYGTLSAVAFTFVSYIILSFLMS---------------------- 349
            |||:||||:||:|::|..::|.|||.|:..|.|:|:.::.::|
Zfish   337 TGILAGANISGDLRDPQGALPKGTLLAIFITGVTYLGIALVVSVTVVRDATGNRNDTIQAGASCN 401

  Fly   350 ----CTTPY-----------FTMQNNYLFLMPVNLWPPFTAIGILTATFSTSLSNLIGSSRILEA 399
                |...|           :.:.||:..:..|:.:.|....|..:||.|::|::|:.:.::.:|
Zfish   402 FSSACDFGYDFSICQTTKCNYGLMNNFQVMTLVSGFGPLITAGTFSATLSSALASLVSAPKVFQA 466

  Fly   400 LSKDQVFGSLLNFVIHGTWKGN-PIAAVAVSWCLVECILLIGSFNIIAQINSVLFMLSYLATNLA 463
            |.||.:: ..|.|...|..|.| ||....:::.:....:||...|.||.|.|..|:.||...|.:
Zfish   467 LCKDNIY-KALKFFAKGHGKNNEPIRGYVLTFIIAVAFILIAQLNTIAPIISNFFLASYALINYS 530

  Fly   464 CLGIELTGAPNFRPLFKFFTWHTCLVGLLGTLIMMFVINFIYASSCIILCLILVIALHLFSPATQ 528
            |.......:|.:||.:|::.....|.|.:....:|||||:..|.....:...|.|.:.:..|
Zfish   531 CFHASYAKSPGWRPAYKYYNMWLSLFGAVLCCAVMFVINWWAALLTYGIEFFLYIYVTVKKP--- 592

  Fly   529 AAQWGSISQALMFHQVRKYLLMLDPRKDHVKFWRPQILLLVSSPRSCCPLVDFVNDLKKS-GLYI 592
            ...|||.:||:.|.......|:|....||:|.:||:.|:|..||||...|:|..:...|: ||.:
Zfish   593 DVNWGSSTQAVTFINAVNNALILSGVDDHIKNFRPKCLVLTGSPRSRPALLDLSHSFTKNYGLCL 657

  Fly   593 IGHVKLGD-FKGIEDAED----NQQWWSFLDHMRVKAFTEVTLSRSIREGVQHLIRLSGIGAMKP 652
            ...|.:|. .|.::|..:    ||.|   |:..:.|||.....|.::|:|.|.|::.||:|.|||
Zfish   658 TCEVFVGSRDKNLQDMIEGDVQNQLW---LNKQKHKAFYTPIASDTLRDGAQALMQASGLGRMKP 719

  Fly   653 NTIILGF---YDSEAPRDFFQNGSSPYKTDDFNNGEI-----QNFPI----RRDGDPKQFQIQEY 705
            ||::|||   :.:..|:|........:.|.||..|.:     |...|    :.:.:.::..:::
Zfish   720 NTVMLGFKRDWRTSKPQDVQNYVGILHDTFDFELGTVIMRVSQGMDISHILKAEEEMERMILEQ- 783

  Fly   706 VQILCDTLRMKKNLCLCRNFQ---------------------------------RLDKNFISMSK 737
                 ..|.|::|     :||                                 :|::..:..|.
Zfish   784 -----QALEMEEN-----DFQPGPRGFFNRAKKTPKKEPTSKVSLGVPQASDLAKLNQRLVEASG 838

  Fly   738 HVKY------IDVWPINIFNPTSGDPFDMVSLFMMQLAVIML-AKWKHLRVRIFLCEANDER--- 792
            ..|.      ||||.:          ||...|.::...::.. .||:..|:|||:. ...||
Zfish   839 QFKQQQGKGNIDVWWL----------FDDGGLTLLLPHILTTRKKWRECRLRIFIA-GQPERIQQ 892

  Fly   793 -------TVGTFDTQTPQMEIFSKMKLEQSLKELRITADIVE---IQEWSRD---TDFSRHARTL 844
                   .:..|..:...:::.|.:.:..|.:..::..|::|   :.|.|:|   |:..|..:..
Zfish   893 DKEEMQLLLKKFRIKCEDIKVISDLNIRPSAENWKLFEDMIEPFRLHEGSKDSSQTEALRKEQPW 957

  Fly   845 KQFTAQADNVVLEDDDEVGEETLNRSLLYMQRANQIIRERSDQTALSFIYLAAPPKLSAPDFAQR 909
            |...|:.|             ...:..:...|.|::::|.|....|..:.|....|.|..|..
Zfish   958 KITDAELD-------------AFEQKTMLQVRLNELLQESSRAAKLIVVSLPIARKGSVSDHL-- 1007

  Fly   910 SASYMELLTELTADLPPTILVHG----VSTVTS 938
               ||..|..||.:||||:|:.|    |.|:.|
Zfish  1008 ---YMAWLEALTKNLPPTLLIRGNHKSVLTIYS 1037

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10413	NP_001286048.1	2a30	22..932	CDD:273347	263/1041 (25%)
		SLC12	577..932	CDD:281515	95/428 (22%)
slc12a1	XP_021323409.1	2a30	45..1037	CDD:273347	270/1071 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910