DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment amos and NEUROD4

DIOPT Version :9

Sequence 1:	NP_477446.1	Gene:	amos / 35110	FlyBaseID:	FBgn0003270	Length:	198	Species:	Drosophila melanogaster
Sequence 2:	NP_067014.2	Gene:	NEUROD4 / 58158	HGNCID:	13802	Length:	331	Species:	Homo sapiens

Alignment Length:	137	Identity:	44/137 - (32%)
Similarity:	63/137 - (45%)	Gaps:	17/137 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 QEQQQHHLQANPLGKNQGRSPRYWNKQQRSKP--YDKLSTSMSSSTSSASSSSSSSAG----FGG 133
            :.::...|...|...::|...:...|::.|:|  |..||:......|..........|    ..|
Human     7 KSKEMGELVNTPSWMDKGLGSQNEVKEEESRPGTYGMLSSLTEEHDSIEEEEEEEEDGEKPKRRG 71

  Fly   134 EVLKK-----------RRLAANARERRRMNSLNDAFDKLRDVVPSLGHDRRLSKYETLQMAQAYI 187
            ...||           ||:.||||||.||:.||||.|.||.|:|.....::|||.|||::|:.||
Human    72 PKKKKMTKARLERFRARRVKANARERTRMHGLNDALDNLRRVMPCYSKTQKLSKIETLRLARNYI 136

  Fly   188 GDLVTLL 194
            ..|..:|
Human   137 WALSEVL 143

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amos	NP_477446.1	HLH	137..195	CDD:238036	32/69 (46%)
NEUROD4	NP_067014.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..80		14/72 (19%)
		HLH	88..144	CDD:238036	30/56 (54%)
		Neuro_bHLH	146..264	CDD:289310
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	246..265
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2611
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940