DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment amos and NEUROD2

DIOPT Version :9

Sequence 1:	NP_477446.1	Gene:	amos / 35110	FlyBaseID:	FBgn0003270	Length:	198	Species:	Drosophila melanogaster
Sequence 2:	NP_006151.3	Gene:	NEUROD2 / 4761	HGNCID:	7763	Length:	382	Species:	Homo sapiens

Alignment Length:	119	Identity:	38/119 - (31%)
Similarity:	55/119 - (46%)	Gaps:	23/119 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 EQQQHHLQANPLGKNQGRSPRYWNKQQRSKPYDKLSTSMSSSTSSASSSSSSSAGFGGEVLKKRR 140
            |:::...:...|.:.:|..|:....::|.....:|..|                       |.||
Human    82 EEEEEEEEEEGLDEAEGERPKKRGPKKRKMTKARLERS-----------------------KLRR 123

  Fly   141 LAANARERRRMNSLNDAFDKLRDVVPSLGHDRRLSKYETLQMAQAYIGDLVTLL 194
            ..||||||.||:.||.|.|.||.|||.....::|||.|||::|:.||..|..:|
Human   124 QKANARERNRMHDLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEIL 177

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amos	NP_477446.1	HLH	137..195	CDD:238036	31/58 (53%)
NEUROD2	NP_006151.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..129		12/69 (17%)
		bHLH_TS_NeuroD2	88..180	CDD:381563	37/113 (33%)
		Nuclear localization signal. /evidence=ECO:0000255	107..113		1/5 (20%)
		Neuro_bHLH	180..310	CDD:403655
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145420
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840