DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment amos and ATOH1

DIOPT Version :9

Sequence 1:	NP_477446.1	Gene:	amos / 35110	FlyBaseID:	FBgn0003270	Length:	198	Species:	Drosophila melanogaster
Sequence 2:	NP_005163.1	Gene:	ATOH1 / 474	HGNCID:	797	Length:	354	Species:	Homo sapiens

Alignment Length:	211	Identity:	73/211 - (34%)
Similarity:	95/211 - (45%)	Gaps:	59/211 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PDEAPAIPEFLSNDTFQQLEQLMYQQEFSTSDSQSDGANSCSLEMYYDTPSVLELEHMLNAQEQQ 78
            |.:.||        |.|..|..:|..|.|..||....|        :..|:   |:.:..|: ..
Human    34 PPQPPA--------TLQAREHPVYPPELSLLDSTDPRA--------WLAPT---LQGICTAR-AA 78

  Fly    79 QHHLQANPLGKNQGRSPRYWNKQQRSKPYDKLSTSMSSSTSSASSSSS----------------- 126
            |:.|.:..||.::..:||        ...|.....:..|:..||||.|
Human    79 QYLLHSPELGASEAAAPR--------DEVDGRGELVRRSSGGASSSKSPGPVKVREQLCKLKGGV 135

  Fly   127 -------------SSAGFGGEVLKKRRLAANARERRRMNSLNDAFDKLRDVVPSLGHDRRLSKYE 178
                         ||....| |.|:|||||||||||||:.||.|||:||:|:||..:|::|||||
Human   136 VVDELGCSRQRAPSSKQVNG-VQKQRRLAANARERRRMHGLNHAFDQLRNVIPSFNNDKKLSKYE 199

  Fly   179 TLQMAQAYIGDLVTLL 194
            ||||||.||..|..||
Human   200 TLQMAQIYINALSELL 215

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amos	NP_477446.1	HLH	137..195	CDD:238036	41/58 (71%)
ATOH1	NP_005163.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55		8/28 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	91..122		9/38 (24%)
		HLH	158..216	CDD:238036	41/58 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	216..277		73/211 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	312..354
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145422
Domainoid	1	1.000	79	1.000	Domainoid score	I8721
eggNOG	1	0.900	-	-		E1_KOG4395
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto89492
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR19290
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2611
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.870